PCIDB

Ozothamnus scutellifolius

Species

KNApSAcK Entry

Organism name Ozothamnus scutellifolius
Genus Ozothamnus
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ozothamnus scutellifolius
Linked NCBI taxonomy ID 1284902
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001036 External link 512 Diosmetin
/ 4'-Methylluteolin
/ 5,7,3'-Trihydroxy-4'-methoxyflavone
CHEMBL90568
C039602
11 / 12 / 8 5 / 0 No. 3 No. 15
C00001060 External link 512 Kaempferide
CHEMBL40919
6 / 7 / 4 No. 3 No. 15
C00004647 External link 512 Ayanin
/ 3,7,4'-Tri-O-methylquercetin
/ 5,3'-Dihydroxy-3,7,4'-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL74898
18 / 10 / 2 No. 3 No. 15
C00003851 External link 512 Takakin
/ 5,7,8-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
No. 3 No. 15
C00004567 External link 512 Rhamnocitrin
/ 7-Methylkaempferol
/ 3,4',5-Trihydroxy-7-methoxyflavone
/ 3,5-Dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL442289
No. 3 No. 15
C00004634 External link 512 Rhamnetin
/ 7-Methoxyquercetin
/ 3,5,3',4'-Tetrahydroxy-7-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one
CHEMBL312163
C063423
20 / 27 / 27 No. 3 No. 15
C00004638 External link 512 Quercetin 3,7-dimethyl ether
/ 5,3',4'-Trihydroxy-3,7-dimethoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL164861
C065497
2 / 1 / 2 No. 3 No. 15
C00004571 External link 512 Kaempferol 7,4'-dimethyl ether
/ 3,5-Dihydroxy-7,4'-dimethoxyflavone
/ 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
No. 3 No. 15
C00004573 External link 512 3,7,4'-Tri-O-methylkaempferol
/ Kaempferol 3,7,4'-trimethyl ether
/ 5-Hydroxy-3,7,4'-trimethoxyflavone
/ 5-Hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL77686
No. 35 No. 15
C00003848 External link 512 Isoscutellarein
/ 8-Hydroxyapigenin
/ 4',5,7,8-Tetrahydroxyflavone
/ 5,7,8-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
No. 71 No. 15

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001036 C00001060 C00004647 2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001036 C00001060 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00001036 C00004647 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001036 C00001060 0 / 0
P04745 Alpha-amylase 1 Enzyme C00001036 C00004634 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001036 C00001060 4 / 4
P08183 Multidrug resistance protein 1 drug C00001060 C00004647 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001036 C00004634 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00004634 3 / 1
P02545 Prelamin-A/C Unclassified protein C00004634 11 / 10
P04792 Heat shock protein beta-1 Unclassified protein C00004634 2 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004634 0 / 0
P15121 Aldose reductase Enzyme C00004634 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001036 5 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001036 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00004634 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00004634 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00004634 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00004634 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004634 3 / 3
P00747 Plasminogen S1A C00004638 1 / 2
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001036 1 / 1
Q02880 DNA topoisomerase 2-beta Isomerase C00001060 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00004634 0 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00004638 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00004634 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001036 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004634 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004634 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00004634 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00004634 1 / 1
O00255 Menin Unclassified protein C00004634 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004634 1 / 2
Q13748 Tubulin alpha-3C/D chain Structural C00004647 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004647 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004647 1 / 0
P04350 Tubulin beta-4A chain Structural C00004647 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004647 0 / 0
P07437 Tubulin beta chain Structural C00004647 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004647 1 / 1
P68371 Tubulin beta-4B chain Structural C00004647 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004647 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00004647 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004647 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004647 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004647 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004647 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004647 1 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001036
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001036
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001036
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001036
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001036

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (48)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#237500 Dubin-johnson syndrome; djs Q92887
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#217090 Plasminogen deficiency, type i P00747
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (38)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00747 (related)
H01206 Plasminogen deficiency P00747 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)