Lophophora williamsii
Species
KNApSAcK Entry
| Organism name | Lophophora williamsii |
|---|---|
| Genus | Lophophora |
| Family | Cactaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lophophora williamsii |
|---|---|
| Linked NCBI taxonomy ID | 130138 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cactaceae |
|---|---|
| ID | 3593 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (47)
| Species | Activity |
|---|---|
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Analgesic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Analgesic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Anorective |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Antiseptic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Antiseptic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Antispasmodic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Antispasmodic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Asthmatic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Asthmatic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Bradycardiac |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Bradycardic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Cardiotonic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Cardiotonic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | CNS Deressant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | CNS-Depressant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Emetic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Emetic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hallucinogen |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hallucinogen |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hypoglycemic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hypoglycemic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hypotensive |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Hypotensive |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Intoxicant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Intoxicant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Lactagogue |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Lactagogue |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Narcotic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Narcotic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Panacea |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Panacea |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Poison |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Poison |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Psychedelic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Psychedelic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Respiradepressant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Respirodepressant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Sedative |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Sedative |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Stimulant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Stimulant |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Sympathicomimetic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Sympathomimetic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Tonic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Tonic |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Vasodilator |
| Lophophora williamsii (Lem. Ex Salm-Dyck) J. M. Coult. | Vasodilator |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001421
|
N-Methylmescaline
|
CHEMBL100531
|
No. 723 | No. 6 |
|
|||
|
C00001419
|
Mescaline
|
CHEMBL26687
|
D008635
|
3 / 0 / 0 | 0 / 1 | No. 723 | No. 6 |
|
|
C00001435
|
Tyramine
|
CHEMBL11608
|
D014439
|
23 / 11 / 6 | 6 / 9 | No. 936 | No. 6 |
|
|
C00001408
|
Dopamine
|
CHEMBL59
|
D004298
|
69 / 40 / 56 | 51 / 52 | No. 1114 | No. 6 |
|
|
C00042228
|
Anhalamine
|
No. 1943 | No. 4 |
|
||||
|
C00001901
|
Pellotine
|
CHEMBL1186202
|
C016645
|
No. 1943 | No. 4 |
|
||
|
C00001881
|
Lophophorine
|
C008296
|
No. 4329 | No. 4 |
|
Human Protein / Gene in interactions
81 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001408 C00001435 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001408 C00001435 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001408 C00001435 | 0 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001408 C00001435 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001408 C00001435 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001408 C00001435 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001408 C00001435 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00001408 C00001435 | 4 / 2 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001408 C00001435 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001408 C00001435 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001408 C00001435 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001408 C00001435 | 2 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001408 C00001435 | 0 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001408 C00001435 | 0 / 0 |
| P49286 | Melatonin receptor type 1B | Melatonin receptor | C00001408 | 0 / 1 |
| O43704 | Sulfotransferase family cytosolic 1B member 1 | Enzyme | C00001408 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001408 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001435 | 1 / 1 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001408 | 1 / 0 |
| P21918 | D(1B) dopamine receptor | Dopamine receptor | C00001408 | 1 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001408 | 0 / 0 |
| O95622 | Adenylate cyclase type 5 | Enzyme | C00001408 | 1 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001408 | 0 / 0 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | C00001408 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00001408 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001408 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001408 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001408 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001408 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001408 | 1 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001408 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001408 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001435 | 0 / 0 |
| P50225 | Sulfotransferase 1A1 | Enzyme | C00001408 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00001408 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00001435 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001408 | 1 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00001435 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001419 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001408 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001435 | 0 / 0 |
| P50224 | Sulfotransferase 1A3/1A4 | Enzyme | C00001408 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001435 | 2 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001408 | 2 / 0 |
| P48039 | Melatonin receptor type 1A | Melatonin receptor | C00001408 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001408 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00001435 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001408 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001408 | 0 / 1 |
| Q16853 | Membrane primary amine oxidase | Enzyme | C00001408 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001408 | 3 / 3 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001408 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001419 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001419 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001408 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00001408 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001408 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001408 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001408 | 7 / 37 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001408 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00001408 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001408 | 4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00001408 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001408 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001408 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001408 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001408 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00001408 | 3 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001408 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00001408 | 1 / 1 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00001408 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001408 | 1 / 1 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001435 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001408 | 0 / 0 |
| Q96RJ0 | Trace amine-associated receptor 1 | Trace amine receptor | C00001435 | 0 / 0 |
52 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6530 | SLC6A2, NAT1, NET, NET1, SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 2 |
C00001408
C00001435
|
| 134864 | TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 | trace amine associated receptor 1 |
C00001408
C00001435
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00001408
C00001435
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00001408
C00001435
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00001408
C00001435
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001408
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001408
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001408
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00001408
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001408
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00001408
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001408
|
| 1812 | DRD1, DADR, DRD1A | dopamine receptor D1 |
C00001408
|
| 1813 | DRD2, D2DR, D2R | dopamine receptor D2 |
C00001408
|
| 2152 | F3, CD142, TF, TFA | coagulation factor III (thromboplastin, tissue factor) |
C00001408
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00001408
|
| 2668 | GDNF, ATF1, ATF2, HFB1-GDNF, HSCR3 | glial cell derived neurotrophic factor |
C00001408
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00001408
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00001408
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00001408
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00001408
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00001408
|
| 3359 | HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
C00001408
|
| 9177 | HTR3B, 5-HT3B | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic |
C00001408
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001408
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00001408
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001408
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001408
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00001408
|
| 2475 | MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) |
C00001408
|
| 4548 | MTR, HMAG, MS, cblG | 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) |
C00001408
|
| 5071 | PARK2, AR-JP, LPRS2, PDJ, PRKN | parkin RBR E3 ubiquitin protein ligase |
C00001408
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001408
|
| 5617 | PRL | prolactin |
C00001408
|
| 5998 | RGS3, C2PA, RGP3 | regulator of G-protein signaling 3 |
C00001408
|
| 6198 | RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) |
C00001408
|
| 6343 | SCT | secretin |
C00001408
|
| 6570 | SLC18A1, CGAT, VAT1, VMAT1 | solute carrier family 18 (vesicular monoamine transporter), member 1 |
C00001408
|
| 6571 | SLC18A2, SVAT, SVMT, VAT2, VMAT2 | solute carrier family 18 (vesicular monoamine transporter), member 2 |
C00001408
|
| 85413 | SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1 | solute carrier family 22 (organic cation/carnitine transporter), member 16 |
C00001408
|
| 9016 | SLC25A14, BMCP1, UCP5 | solute carrier family 25 (mitochondrial carrier, brain), member 14 |
C00001408
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00001408
|
| 664 | BNIP3, NIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
C00001408
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001408
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00001408
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00001408
|
| 27113 | BBC3, JFY-1, JFY1, PUMA | BCL2 binding component 3 |
C00001408
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001408
|
| 7054 | TH, DYT14, DYT5b, TYH | tyrosine hydroxylase (EC:1.14.16.2) |
C00001408
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001408
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001408
|
| 4128 | MAOA, MAO-A | monoamine oxidase A (EC:1.4.3.4) |
C00001435
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (43)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P14416
P31645 |
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #606798 | Blepharospasm, benign essential |
P21918
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #606703 | Dyskinesia, familial, with facial myokymia; fdfm |
O95622
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #159900 | Myoclonic dystonia |
P14416
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
KEGG DISEASE (57)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00409 | Type II diabetes mellitus |
P49286
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
59 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006973 | Hypertension |
C00001408
C00001435 |
| D013610 | Tachycardia |
C00001408
C00001435 |
| D007022 | Hypotension |
C00001408
C00001435 |
| D017202 | Myocardial Ischemia |
C00001408
|
| D002303 | Cardiac Output, Low |
C00001408
|
| D002375 | Catalepsy |
C00001408
|
| D002389 | Catatonia |
C00001408
|
| D002493 | Central Nervous System Diseases |
C00001408
|
| D019970 | Cocaine-Related Disorders |
C00001408
|
| D004342 | Drug Hypersensitivity |
C00001408
|
| D062787 | Drug Overdose |
C00001408
|
| D004409 | Dyskinesia, Drug-Induced |
C00001408
|
| D004417 | Dyspnea |
C00001408
|
| D004802 | Eosinophilia |
C00001408
|
| D006323 | Heart Arrest |
C00001408
|
| D006331 | Heart Diseases |
C00001408
|
| D006333 | Heart Failure |
C00001408
|
| D006556 | Heroin Dependence |
C00001408
|
| D006930 | Hyperalgesia |
C00001408
|
| D006948 | Hyperkinesis |
C00001408
|
| D058186 | Acute Kidney Injury |
C00001408
|
| D007008 | Hypokalemia |
C00001408
|
| D018476 | Hypokinesia |
C00001408
|
| D001145 | Arrhythmias, Cardiac |
C00001408
|
| D007024 | Hypotension, Orthostatic |
C00001408
|
| D007859 | Learning Disorders |
C00001408
|
| D008133 | Long QT Syndrome |
C00001408
|
| D020149 | Manganese Poisoning |
C00001408
|
| D048629 | Micronuclei, Chromosome-Defective |
C00001408
|
| D001480 | Basal Ganglia Diseases |
C00001408
|
| D009205 | Myocarditis |
C00001408
|
| D009336 | Necrosis |
C00001408
|
| D009410 | Nerve Degeneration |
C00001408
|
| D009422 | Nervous System Diseases |
C00001408
|
| D009846 | Oliguria |
C00001408
|
| D010300 | Parkinson Disease |
C00001408
|
| D020734 | Parkinsonian Disorders |
C00001408
|
| D010547 | Persistent Fetal Circulation Syndrome |
C00001408
|
| D011595 | Psychomotor Agitation |
C00001408
|
| D012127 | Respiratory Distress Syndrome, Newborn |
C00001408
|
| D012640 | Seizures |
C00001408
|
| D012769 | Shock |
C00001408
|
| D012770 | Shock, Cardiogenic |
C00001408
|
| D012772 | Shock, Septic |
C00001408
|
| D013226 | Status Epilepticus |
C00001408
|
| D013375 | Substance Withdrawal Syndrome |
C00001408
|
| D000788 | Angina Pectoris, Variant |
C00001408
|
| D013616 | Tachycardia, Sinus |
C00001408
|
| D016171 | Torsades de Pointes |
C00001408
|
| D014202 | Tremor |
C00001408
|
| D020301 | Vasospasm, Intracranial |
C00001408
|
| D018487 | Ventricular Dysfunction, Left |
C00001408
|
| D011605 | Psychoses, Substance-Induced |
C00001419
|
| D009202 | Cardiomyopathies |
C00001435
|
| D002543 | Cerebral Hemorrhage |
C00001435
|
| D002637 | Chest Pain |
C00001435
|
| D008881 | Migraine Disorders |
C00001435
|
| D015878 | Mydriasis |
C00001435
|
| D011041 | Poisoning |
C00001435
|