Buddleja globosa
Species
KNApSAcK Entry
| Organism name | Buddleja globosa |
|---|---|
| Genus | Buddleja |
| Family | Buddlejaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Buddleja globosa |
|---|---|
| Linked NCBI taxonomy ID | 168495 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Scrophulariaceae |
|---|---|
| ID | 4149 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002783
|
Kusaginin
/ Acteoside / Verbascoside |
CHEMBL231853
CHEMBL444478 CHEMBL1364101 |
C058956
|
12 / 1 / 1 | 34 / 3 | No. 33 |
|
|
|
C00036069
|
Buddlejone
/ (-)-Buddlejone |
CHEMBL487591
|
No. 1020 | No. 40 |
|
|||
|
C00036112
|
Deoxybuddlejone
|
CHEMBL506233
|
No. 1020 | No. 40 |
|
|||
|
C00012487
|
Buddledin B
|
CHEMBL519046
|
No. 1956 |
|
||||
|
C00012467
|
Zerumbone
|
CHEMBL245412
|
C403304
|
4 / 2 / 2 | 27 / 1 | No. 2272 |
|
|
|
C00036063
|
Buddledone A
|
No. 2272 |
|
|||||
|
C00003105
|
Buddledin A
|
CHEMBL485981
|
1 / 0 / 0 | No. 3073 | No. 38 |
|
||
|
C00036064
|
Buddledone B
|
No. 8673 |
|
Human Protein / Gene in interactions
17 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00012467 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002783 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002783 | 1 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00002783 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003105 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002783 | 0 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00012467 | 0 / 0 |
| P10070 | Zinc finger protein GLI2 | Unclassified protein | C00012467 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002783 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002783 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002783 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00012467 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002783 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002783 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002783 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002783 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002783 | 0 / 0 |
56 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002783
C00012467
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002783
C00012467
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002783
C00012467
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002783
C00012467
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002783
C00012467
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00002783
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002783
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00002783
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00002783
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00002783
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002783
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002783
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00002783
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002783
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00002783
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002783
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00002783
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00002783
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002783
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002783
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00002783
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002783
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002783
|
| 27035 | NOX1, GP91-2, MOX1, NOH-1, NOH1 | NADPH oxidase 1 |
C00002783
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002783
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002783
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002783
|
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 |
C00002783
|
| 896 | CCND3 | cyclin D3 |
C00002783
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002783
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00002783
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00002783
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00002783
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002783
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00012467
|
| 597 | BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 | BCL2-related protein A1 |
C00012467
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00012467
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00012467
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00012467
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00012467
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00012467
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00012467
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00012467
|
| 9020 | MAP3K14, FTDCR1B, HS, HSNIK, NIK | mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) |
C00012467
|
| 4314 | MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) |
C00012467
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00012467
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00012467
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00012467
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00012467
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00012467
|
| 7132 | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 | tumor necrosis factor receptor superfamily, member 1A |
C00012467
|
| 8717 | TRADD, Hs.89862 | TNFRSF1A-associated via death domain |
C00012467
|
| 7185 | TRAF1, EBI6, MGC:10353 | TNF receptor-associated factor 1 |
C00012467
|
| 7186 | TRAF2, MGC:45012, TRAP, TRAP3 | TNF receptor-associated factor 2 |
C00012467
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00012467
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00012467
|