Plantago cretica
Species
KNApSAcK Entry
| Organism name | Plantago cretica |
|---|---|
| Genus | Plantago |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Plantago cretica |
|---|---|
| Linked NCBI taxonomy ID | 197801 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002783
|
Kusaginin
/ Acteoside / Verbascoside |
CHEMBL231853
CHEMBL444478 CHEMBL1364101 |
C058956
|
12 / 1 / 1 | 34 / 3 | No. 33 |
|
|
|
C00003072
|
Asperuloside
|
CHEMBL461910
CHEMBL1965021 |
C077956
|
1 / 0 / 0 | No. 100 | No. 36 |
|
|
|
C00003073
|
Aucubin
|
CHEMBL514882
CHEMBL1873725 CHEMBL1874462 |
C006650
|
5 / 1 / 1 | No. 100 | No. 36 |
|
|
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
|
C00001173
|
Sorbitol
/ D-Sorbitol / D-Glucitol / (-)-Sorbitol |
CHEMBL16105
CHEMBL689 CHEMBL1682 CHEMBL1735282 CHEMBL1773904 |
D013012
|
101 / 49 / 42 | 8 / 5 | No. 630 |
|
Human Protein / Gene in interactions
124 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001173 C00002783 C00003072 C00003073 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001173 C00002724 C00002783 C00003073 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001173 C00002783 C00003073 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001173 C00002724 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001173 C00002724 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001173 C00002724 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 C00002783 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001173 C00002724 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001173 C00002724 | 2 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001173 C00002724 | 0 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002783 C00003073 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001173 C00003073 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001173 C00002724 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001173 C00002724 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001173 C00002724 | 1 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001173 C00002783 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002724 C00002783 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002724 C00002783 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001173 C00002783 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001173 C00002724 | 0 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001173 | 1 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001173 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001173 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001173 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001173 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001173 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001173 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001173 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001173 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001173 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001173 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001173 | 11 / 10 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001173 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001173 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001173 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001173 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001173 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001173 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001173 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001173 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001173 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001173 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001173 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002724 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001173 | 0 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001173 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001173 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001173 | 2 / 2 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001173 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001173 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001173 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001173 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001173 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001173 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001173 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002724 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001173 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001173 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001173 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001173 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001173 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001173 | 1 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| P03956 | Interstitial collagenase | M10A | C00001173 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001173 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001173 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001173 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001173 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001173 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001173 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001173 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001173 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001173 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001173 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001173 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001173 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001173 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001173 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001173 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001173 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001173 | 2 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001173 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002724 | 3 / 3 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001173 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002724 | 3 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002724 | 3 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001173 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001173 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001173 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001173 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001173 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001173 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001173 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001173 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001173 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00001173 | 2 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001173 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002783 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00001173 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002724 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001173 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001173 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001173 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001173 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001173 | 1 / 1 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 | 0 / 0 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001173 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002783 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002724 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002783 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002724 | 1 / 1 |
| P10323 | Acrosin | S1A | C00001173 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001173 | 1 / 1 |
79 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002783
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00002783
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002783
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002783
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00002783
|
| 896 | CCND3 | cyclin D3 |
C00002783
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002783
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00002783
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00002783
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00002783
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002783
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002783
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00002783
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002783
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00002783
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002783
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002783
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00002783
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002783
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002783
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00002783
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002783
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002783
|
| 27035 | NOX1, GP91-2, MOX1, NOH-1, NOH1 | NADPH oxidase 1 |
C00002783
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002783
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002783
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002783
|
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 |
C00002783
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00002783
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002783
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00002783
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00002783
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002783
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002783
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
|
| 1977 | EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F | eukaryotic translation initiation factor 4E |
C00001173
|
| 1978 | EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I | eukaryotic translation initiation factor 4E binding protein 1 |
C00001173
|
| 5602 | MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK | mitogen-activated protein kinase 10 (EC:2.7.11.24) |
C00001173
|
| 6300 | MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3 | mitogen-activated protein kinase 12 (EC:2.7.11.24) |
C00001173
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00001173
|
| 9261 | MAPKAPK2, MAPKAP-K2, MK-2, MK2 | mitogen-activated protein kinase-activated protein kinase 2 (EC:2.7.11.1) |
C00001173
|
| 8569 | MKNK1, MNK1 | MAP kinase interacting serine/threonine kinase 1 (EC:2.7.11.1) |
C00001173
|
| 51035 | UBXN1, 2B28, SAKS1, UBXD10 | UBX domain protein 1 |
C00001173
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (65)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (52)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
17 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00002783
|
| D007938 | Leukemia |
C00002783
|
| D014947 | Wounds and Injuries |
C00002783
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D008545 | Melanoma |
C00002724
|
| D009336 | Necrosis |
C00002724
|
| D015431 | Weight Loss |
C00002724
|
| D048909 | Diabetes Complications |
C00001173
|
| D003929 | Diabetic Neuropathies |
C00001173
|
| D004660 | Encephalitis |
C00001173
|
| D010146 | Pain |
C00001173
|
| D010523 | Peripheral Nervous System Diseases |
C00001173
|