Magnolia officinalis

• Index
• Plant Species
• Metabolite list (18)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Magnolia officinalis
Genus	Magnolia
Family	Magnoliaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Magnolia officinalis
Linked NCBI taxonomy ID	85864
Linked level	species

Family

Family in NCBI taxonomy	Magnoliaceae
ID	3401

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Magnoliophyta
ID	3398

Metabolite list (18)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00034404	Aceoside	CHEMBL449185				No. 17	No. 11
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 38	No. 21
C00002728	Coniferaldehyde / Coniferyl aldehyde / 4-Hydroxy-3-methoxycinnamaldehyde	CHEMBL242529 CHEMBL1956165	C075384	1 / 1 / 1		No. 310	No. 6
C00000010	Syringin	CHEMBL250872	C028305	1 / 0 / 0	0 / 1	No. 678	No. 6
C00030708	Magnaldehyde E	CHEMBL251060				No. 761	No. 23
C00040486	threo-Honokitriol / (+)-threo-Honokitriol					No. 761	No. 23
C00040143	Randaiol	CHEMBL555924				No. 761	No. 23
C00030707	Magnaldehyde B	CHEMBL250885				No. 761	No. 23
C00002609	Hinokiol / (+)-Hinokiol	CHEMBL16901		26 / 24 / 20		No. 761	No. 23
C00030709	Magnolignan C / (-)-Magnolignan C	CHEMBL399697				No. 761	No. 23
C00000591	Magnolol	CHEMBL180920	C005498	21 / 17 / 15	1 / 7	No. 761	No. 23
C00039712	Magnolignan B					No. 761	No. 23
C00039166	erythro-Honokitriol / (-)-erythro-Honokitriol					No. 761	No. 23
C00007558	Syringaldehyde / 4-Hydroxy-3,5-dimethoxybenzaldehyde	CHEMBL225303	C069665			No. 856
C00024183	Obovatol	CHEMBL491809	C036795			No. 3309
C00039710	Magnatriol B					No. 6327
C00039711	Magnolianone					No. 8461

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00000591 C00002609 C00002783	1 / 1
O75496	Geminin	Unclassified protein	C00000591 C00002609 C00002783	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002609 C00002783	0 / 0
O00255	Menin	Unclassified protein	C00000591 C00002609	2 / 5
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000591 C00002609	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000591 C00002783	0 / 0
Q9GZV3	High affinity choline transporter 1	Choline Na-symporter	C00000591 C00002609	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000591 C00002609	4 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000591 C00002609	1 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000591 C00002609	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00000591 C00002609	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00000591 C00002609	1 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000591 C00002609	0 / 0
Q9Y2T6	G-protein coupled receptor 55	Lysophosphatidylinositol receptor	C00000591 C00002609	0 / 0
P34972	Cannabinoid receptor 2	Cannabinoid receptor	C00000591 C00002609	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000591 C00002609	2 / 0
P39748	Flap endonuclease 1	Enzyme	C00002609 C00002783	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000591	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000591	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000010	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002609	2 / 2
P11387	DNA topoisomerase 1	Isomerase	C00002631	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002609	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002609	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002609	5 / 3
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00002609	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000591	2 / 2
Q9UNA4	DNA polymerase iota	Enzyme	C00002783	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000591	1 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00002728	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002609	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00002609	4 / 2
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002609	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000591	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
P06746	DNA polymerase beta	Enzyme	C00002609	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002609	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000591	1 / 1

35 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00000591
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions