PCIDB

KNApSAcK Metabolite C00000591

Metabolite

KNApSAcK Entry

id C00000591
Name Magnolol
CAS RN 528-43-8
Standard InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
Standard InChI (Main Layer) InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

Cluster

Phytochemical cluster No. 23
KCF-S cluster No. 761

Link

ChEMBL

By standard InChI CHEMBL180920
By standard InChI Main Layer CHEMBL180920

KEGG

By LinkDB C10651

CTD

By CAS RN C005498

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL180920 CHEMBL2114784 (1)
1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL180920 CHEMBL1614076 (1)
1 / 1
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL180920 CHEMBL1816618 (1) CHEMBL1816889 (1)
CHEMBL1817161 (1)
0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL180920 CHEMBL1816618 (1) CHEMBL1816889 (1)
CHEMBL1817161 (1)
1 / 1
P34972 Cannabinoid receptor 2 Cannabinoid receptor CHEMBL180920 CHEMBL2339468 (1) CHEMBL2339880 (1)
CHEMBL2339884 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL180920 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL180920 CHEMBL1614458 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL180920 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL180920 CHEMBL2114843 (1)
0 / 0
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor CHEMBL180920 CHEMBL2339470 (1) CHEMBL2339471 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL180920 CHEMBL2114788 (1)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL180920 CHEMBL2339467 (1) CHEMBL2339881 (1)
CHEMBL2339885 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL180920 CHEMBL1614038 (1)
2 / 2
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL180920 CHEMBL1614052 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL180920 CHEMBL1614250 (1) CHEMBL1614502 (2)
4 / 3
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter CHEMBL180920 CHEMBL1794362 (1) CHEMBL1794546 (1)
1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL180920 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL180920 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL180920 CHEMBL1614257 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL180920 CHEMBL1614257 (2)
1 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL180920 CHEMBL2354287 (1)
1 / 1

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C005498 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma magnolol binds to and results in increased activity of PPARG protein affects binding
/ increases activity
protein 20064974

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (15)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002545 C005498 Brain Ischemia therapeutic
12859431
D056486 C005498 Drug-Induced Liver Injury therapeutic
19280152
D005334 C005498 Fever therapeutic
12859431
D018883 C005498 Heat Stroke therapeutic
12859431
D009203 C005498 Myocardial Infarction therapeutic
8886485
D017180 C005498 Tachycardia, Ventricular therapeutic
8886485
D014693 C005498 Ventricular Fibrillation therapeutic
8886485