PCIDB

Magnolia obovata

Species

KNApSAcK Entry

Organism name Magnolia obovata
Genus Magnolia
Family Magnoliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Magnolia obovata
Linked NCBI taxonomy ID 349509
Linked level species

Family

Family in NCBI taxonomy Magnoliaceae
ID 3401

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027281 External link 512 Anonaine
CHEMBL401798
C098138
1 / 0 / 0 No. 20 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00027390 External link 512 Isolaureline N-oxide
/ (-)-Isolaureline N-oxide
CHEMBL1609956
8 / 9 / 3 No. 286 No. 4
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00000010 External link 512 Syringin
CHEMBL250872
C028305
1 / 0 / 0 0 / 1 No. 678 No. 6
C00030709 External link 512 Magnolignan C
/ (-)-Magnolignan C
CHEMBL399697
No. 761 No. 23
C00030708 External link 512 Magnaldehyde E
CHEMBL251060
No. 761 No. 23
C00030707 External link 512 Magnaldehyde B
CHEMBL250885
No. 761 No. 23
C00002609 External link 512 Hinokiol
/ (+)-Hinokiol
CHEMBL16901
26 / 24 / 20 No. 761 No. 23
C00000591 External link 512 Magnolol
CHEMBL180920
C005498
21 / 17 / 15 1 / 7 No. 761 No. 23
C00029537 External link 512 4-Methoxyhonokiol
/ 4-O-Methyl honokiol
No. 761 No. 23
C00030245 External link 512 Fargesone C
No. 2047 No. 23
C00002602 External link 512 Eudesobovatol A
No. 2844 No. 23
C00012763 External link 512 Eudesmagnolol
/ (-)-Eudesmagnolol
/ [2R-(2alpha,4aalpha,8beta,8abeta)]-Decahydro-8-[(2'-hydroxy-5,5'-di-2-propenyl[1,1'-biphenyl]-2-yl)oxy]-alpha,a,4alpha,8-tetramethyl-2-naphthalenemethanol
No. 2844 No. 23
C00012820 External link 512 Eudesobovatol B
/ [2R-(2alpha,4aalpha,8beta,8abeta)]-Decahydro-8-[2-hydroxy-4-(2-propenyl)-6-[4-(2-propenyl)phenoxy]phenoxy]-alpha,alpha,4a,8-tetramethyl-2-naphthalenemethanol
No. 2844 No. 23
C00012707 External link 512 Eudeshonokiol
/ Eudeshonokiol A
/ (-)-Eudeshonokiol
No. 2844 No. 23
C00030019 External link 512 Coumanolignan
No. 7852

Human Protein / Gene in interactions

69 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00002609 C00003672 C00019308 C00025625 C00027390 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000591 C00002609 C00025625 C00027390 2 / 0
O75496 Geminin Unclassified protein C00000591 C00002609 C00025625 C00027390 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 C00025625 C00027281 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002609 C00025625 C00027390 0 / 0
O00255 Menin Unclassified protein C00000591 C00002609 C00025625 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000591 C00002609 C00025625 1 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00000591 C00002609 C00025625 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025625 C00027390 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000591 C00002609 4 / 3
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00019308 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002609 C00025625 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002609 C00025625 0 / 0
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter C00000591 C00002609 1 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000591 C00002609 0 / 0
P00734 Prothrombin S1A C00003672 C00019308 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000591 C00002609 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 C00019308 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00000591 C00002609 0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00000591 C00002609 1 / 1
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor C00000591 C00002609 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000591 C00027390 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 C00025625 1 / 1
Q99700 Ataxin-2 Unclassified protein C00000591 C00002609 1 / 1
P34972 Cannabinoid receptor 2 Cannabinoid receptor C00000591 C00002609 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00019308 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000591 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000591 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002609 2 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000010 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00027390 7 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein C00002609 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002609 5 / 3
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00002609 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000591 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002609 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000591 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P37840 Alpha-synuclein Unclassified protein C00002609 4 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002609 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002609 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000591 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00027390 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000591 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00000591

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (60)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#218030 Apparent mineralocorticoid excess; ame P80365
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (41)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002545 Brain Ischemia C00000591
D056486 Drug-Induced Liver Injury C00000591
D005334 Fever C00000591
D018883 Heat Stroke C00000591
D009203 Myocardial Infarction C00000591
D017180 Tachycardia, Ventricular C00000591
D014693 Ventricular Fibrillation C00000591
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D001862 Bone Resorption C00000010