PCIDB

KNApSAcK Metabolite C00002609

Metabolite

KNApSAcK Entry

id C00002609
Name Hinokiol / (+)-Hinokiol
CAS RN 564-73-8
Standard InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
Standard InChI (Main Layer) InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

Cluster

Phytochemical cluster No. 23
KCF-S cluster No. 761

Link

ChEMBL

By standard InChI CHEMBL16901
By standard InChI Main Layer CHEMBL16901

KEGG

By LinkDB C10630

CTD

By CAS RN

Human Protein / Gene in interaction

26 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL16901 CHEMBL2114784 (1)
1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL16901 CHEMBL1061424 (1) CHEMBL1061425 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL16901 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL16901 CHEMBL1614076 (1)
1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL16901 CHEMBL1219316 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL16901 CHEMBL2354282 (1)
4 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL16901 CHEMBL1219313 (1) CHEMBL1219314 (1)
CHEMBL1219318 (1)
0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL16901 CHEMBL1816618 (1) CHEMBL1816889 (1)
CHEMBL1817161 (1)
0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL16901 CHEMBL1816618 (1) CHEMBL1816889 (1)
CHEMBL1817161 (1)
1 / 1
P34972 Cannabinoid receptor 2 Cannabinoid receptor CHEMBL16901 CHEMBL2339466 (1) CHEMBL2339880 (1)
CHEMBL2339882 (1) CHEMBL2339884 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL16901 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL16901 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL16901 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL16901 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor CHEMBL16901 CHEMBL2339470 (1) CHEMBL2339471 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL16901 CHEMBL2114788 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL16901 CHEMBL1963893 (1)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL16901 CHEMBL2339881 (1) CHEMBL2339883 (1)
CHEMBL2339885 (1)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL16901 CHEMBL1219317 (1)
5 / 3
Q13133 Oxysterols receptor LXR-alpha NR1H3 CHEMBL16901 CHEMBL1219315 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL16901 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL16901 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL16901 CHEMBL1614502 (1)
4 / 3
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter CHEMBL16901 CHEMBL1794362 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL16901 CHEMBL1614257 (3)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL16901 CHEMBL1614257 (3)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P37231
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (20)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)