PCIDB

Tetraclinus articulata

Species

KNApSAcK Entry

Organism name Tetraclinus articulata
Genus
Family
Kingdom

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00022721 External link 512 Torulosic acid
/ Cupressic acid
/ 13R-Hydroxy-8(17),14-labdadien-19-oic acid
CHEMBL457163
No. 143
C00031283 External link 512 Sandaracopimaric acid
/ (-)-Sandaracopimaric acid
CHEMBL513197
CHEMBL1397211
CHEMBL1410398
CHEMBL1735595
C082072
14 / 13 / 7 No. 208 No. 48
C00022719 External link 512 Torulosol
/ 8(17),14-Labdadiene-13R,19-diol
CHEMBL596905
CHEMBL1521278
3 / 15 / 12 No. 256 No. 46
C00040509 External link 512 Totarolone
No. 760
C00045114 External link 512 Totarolenone
No. 760
C00002609 External link 512 Hinokiol
/ (+)-Hinokiol
CHEMBL16901
26 / 24 / 20 No. 761 No. 23

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00002609 C00031283 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002609 C00031283 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002609 C00031283 0 / 0
O75496 Geminin Unclassified protein C00002609 C00031283 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002609 C00031283 2 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00002609 C00031283 1 / 1
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor C00002609 0 / 0
P02545 Prelamin-A/C Unclassified protein C00022719 11 / 10
P37840 Alpha-synuclein Unclassified protein C00002609 4 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002609 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00031283 0 / 1
Q16637 Survival motor neuron protein Unclassified protein C00022719 4 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002609 0 / 0
P34972 Cannabinoid receptor 2 Cannabinoid receptor C00002609 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002609 2 / 2
P39748 Flap endonuclease 1 Enzyme C00002609 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002609 1 / 1
P06746 DNA polymerase beta Enzyme C00002609 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00031283 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002609 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00031283 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00031283 1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00002609 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002609 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002609 5 / 3
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00002609 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00031283 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00031283 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00022719 0 / 1
Q99700 Ataxin-2 Unclassified protein C00002609 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002609 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002609 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00031283 0 / 0
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter C00002609 1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00031283 1 / 0
O00255 Menin Unclassified protein C00002609 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002609 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (48)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (37)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)