phytochemical cluster No. 48 (35 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (2)
• Metabolite list (35)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	32
rosids	11
Liliopsida	10
asterids	10
Magnoliophyta	3
Embryophyta	1

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Cumulative family count

class name	count
Cupressaceae	18
Pinaceae	11
Poaceae	7
Lamiaceae	5
Meliaceae	5
Euphorbiaceae	3
Calceolariaceae	3
Annonaceae	2
Zingiberaceae	2
Cistaceae	2
Araucariaceae	1
Podocarpaceae	1
Brassicaceae	1
Araliaceae	1
Plagiochilaceae	1
Asteraceae	1
Taxaceae	1
Alismataceae	1
Schisandraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Pimaranes	5

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Pimaranes	C11877	C00000883
Pimaranes	C09118	C00003444
Pimaranes	C09148	C00003461
Pimaranes	C09159	C00003468
Pimaranes	C06086	C00048512

KCF-S cluster (2)

KCF-S ID	# of metabolite
No. 208	29
No. 1309	6

Metabolite list (35)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00000867	ent-Sandaracopimaradiene					No. 208
C00000883	Pimara-8(14),15-diene					No. 208
C00000904	Sandaracopimaradiene / (-)-Sandaracopimaradiene					No. 208
C00003444	Sandaracopimarinol					No. 208
C00048512	Lecheronol A / (+)-Lecheronol A	CHEMBL466163				No. 208
C00003468	Sandaracopimarinol acetate					No. 208
C00031283	Oryzalexin F	CHEMBL254637 CHEMBL463903				No. 208
C00031284	ent-8(14),15-sandaracopimaradiene-2alpha,18-diol / (+)-ent-8(14),15-sandaracopimaradiene-2alpha,18-diol					No. 208
C00031285	19-Hydroxy-9-epi-ent-7,15-isopimaradiene					No. 208
C00031286	Akhdarenol					No. 208
C00032668	17-Hydroxy-9-epi-ent-7,15-isopimaradiene					No. 208
C00048379	Oryzalexin C					No. 208
C00048309	Isopimara-7,15-dien-3-one	CHEMBL1097037				No. 208
C00034092	Isopimara-7,15-dien-2alpha-ol / (+)-Isopimara-7,15-dien-2alpha-ol					No. 208
C00034094	Virescenol B					No. 208
C00034863	Isopimara-7,15-dien-3beta-ol / (-)-Isopimara-7,15-dien-3beta-ol	CHEMBL225866				No. 208
C00034864	ent-Pimara-8(14),15-dien-18-oic acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7		No. 208
C00048284	Oryzalexin B / (+)-Oryzalexin B					No. 208
C00034866	ent-Pimara-8(14),15-diene / (-)-ent-Pimara-8(14),15-diene	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7		No. 208
C00035989	4-epi-Sandaracopimaric acid / (+)-4-epi-Sandaracopimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7		No. 208
C00036008	Sandaracopimaric acid / (-)-Sandaracopimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595	C082072	14 / 13 / 7		No. 208
C00037101	miropinic acid / Isopimaric acid / isodextropimaric acid	CHEMBL512164	C115138	3 / 1 / 1		No. 208
C00037105	6,7-Dehydrosandaracopimaric acid / (+)-6,7-Dehydrosandaracopimaric acid					No. 208
C00040774	Sagittine A	CHEMBL447656				No. 208
C00040775	Acanthoic acid / (-)-Acanthoic acid	CHEMBL152325 CHEMBL512490 CHEMBL523295		4 / 0 / 0		No. 208
C00040777	3beta-Hydroxyisopimaric acid					No. 208
C00041813	Oryzalexin D / (+)-Oryzalexin D					No. 208
C00042933	3beta-Acetoxy-7,15-isopimaradiene					No. 208
C00049953	Lecheronol B / (+)-Lecheronol B	CHEMBL466164				No. 208
C00043671	Oryzalexin A					No. 1309
C00043670	19-Malonyl-9-epi-ent-7,15-isopimaradiene					No. 1309
C00034091	Isopimara-7,15-diene					No. 1309
C00034090	9beta-Pimara-7,15-diene					No. 1309
C00003461	Sandaracopimarinal					No. 1309
C00034865	(+)-Pimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595	C008911	14 / 13 / 7	9 / 0	No. 1309

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00003444 C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00003444 C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	2 / 0
O75496	Geminin	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003468 C00031283 C00037105 C00048379 C00049953	7 / 3
Q9Y253	DNA polymerase eta	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P55055	Oxysterols receptor LXR-beta	NR1H3	C00035989	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00035989	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003444	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00035989	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00035989	0 / 0

9 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1386	ATF2, CRE-BP1, CREB2, HB16, TREB7	activating transcription factor 2 (EC:2.3.1.48)	C00003468
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00003468
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003468
3727	JUND, AP-1	jun D proto-oncogene	C00003468
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00003468
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00003468
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003468
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00003468
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003468

Related Diseases

Diseases related to proteins in ChEMBL interactions