PCIDB

KNApSAcK Metabolite C00003468

Metabolite

KNApSAcK Entry

id C00003468
Name (+)-Pimaric acid
CAS RN 127-27-5
Standard InChI InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18+,19+,20+/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)

Cluster

Phytochemical cluster No. 48
KCF-S cluster No. 208

Link

ChEMBL

By standard InChI CHEMBL1410398
By standard InChI Main Layer CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595

KEGG

By LinkDB C09159

CTD

By CAS RN C008911

Species

Summary

Plant class

class name count
Spermatophyta 1

Family

family name count
Pinaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Pinus spp. 3318 Pinaceae Spermatophyta Viridiplantae

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1735595 CHEMBL1794585 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1410398 CHEMBL1614027 (1)
0 / 1
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL513197 CHEMBL2148420 (1) CHEMBL2148421 (1)
0 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL513197 CHEMBL2148420 (1) CHEMBL2148421 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1735595 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1397211 CHEMBL2114843 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1397211 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1735595 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL1397211 CHEMBL1794569 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1735595 CHEMBL1738588 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1410398 CHEMBL1613777 (1)
1 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1397211 CHEMBL1737991 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1397211 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1735595 CHEMBL1964002 (1)
1 / 0

CTD interaction (18)

compound gene gene name gene description interaction interaction type form reference
pmid
C008911 1386 ATF2
CRE-BP1
CREB2
HB16
TREB7
activating transcription factor 2 (EC:2.3.1.48) [pimaric acid co-treated with TNF protein] results in decreased expression of ATF2 protein modified form affects cotreatment
/ decreases expression
protein 22705379
C008911 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog pimaric acid inhibits the reaction [JUN protein results in increased expression of FOS protein modified form] decreases reaction
/ increases expression
protein 22705379
C008911 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog pimaric acid inhibits the reaction [TNF protein results in increased expression of FOS protein] decreases reaction
/ increases expression
protein 22705379
C008911 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene pimaric acid inhibits the reaction [JUN protein results in increased expression of FOS protein modified form] decreases reaction
/ increases expression
protein 22705379
C008911 3727 JUND
AP-1
jun D proto-oncogene [pimaric acid co-treated with TNF protein] results in decreased expression of JUND protein affects cotreatment
/ decreases expression
protein 22705379
C008911 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22705379
C008911 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22705379
C008911 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) pimaric acid inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein] decreases reaction
/ increases activity
/ increases expression
protein 22705379
C008911 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) pimaric acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 22705379
C008911 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A pimaric acid inhibits the reaction [TNF protein results in increased expression of RELA protein] decreases reaction
/ increases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [pimaric acid co-treated with TNF protein] results in decreased expression of ATF2 protein modified form affects cotreatment
/ decreases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [pimaric acid co-treated with TNF protein] results in decreased expression of JUND protein affects cotreatment
/ decreases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein] decreases reaction
/ increases activity
/ increases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased expression of FOS protein] decreases reaction
/ increases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased expression of RELA protein] decreases reaction
/ increases expression
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22705379
C008911 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor pimaric acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22705379

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#137800 Glioma susceptibility 1; glm1 O75874
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (7)

KEGG disease name UniProt
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)