KCF-S cluster No. 208 (29 metabolites)

Corresponding Phytochemical cluster No. 48

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (29)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	32
asterids	10
rosids	8
Liliopsida	7
Magnoliophyta	3
Embryophyta	1

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Cumulative family count

class name	count
Cupressaceae	18
Pinaceae	11
Lamiaceae	5
Poaceae	4
Meliaceae	4
Calceolariaceae	3
Zingiberaceae	2
Annonaceae	2
Cistaceae	2
Araucariaceae	1
Podocarpaceae	1
Euphorbiaceae	1
Brassicaceae	1
Araliaceae	1
Plagiochilaceae	1
Asteraceae	1
Taxaceae	1
Alismataceae	1
Schisandraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Pimaranes	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Pimaranes	C11877	C00000883
Pimaranes	C09118	C00003444
Pimaranes	C09159	C00003468
Pimaranes	C06086	C00048512

Metabolite list (29)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000867	9beta-Pimara-7,15-diene
C00000883	ent-Sandaracopimaradiene
C00000904	Virescenol B
C00003444	miropinic acid / Isopimaric acid / isodextropimaric acid	CHEMBL512164	C115138	3 / 1 / 1
C00003468	(+)-Pimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595	C008911	14 / 13 / 7	9 / 0
C00031283	Sandaracopimaric acid / (-)-Sandaracopimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595	C082072	14 / 13 / 7
C00031284	Sandaracopimarinal
C00031285	Sandaracopimarinol
C00031286	Sandaracopimarinol acetate
C00032668	6,7-Dehydrosandaracopimaric acid / (+)-6,7-Dehydrosandaracopimaric acid
C00034092	Oryzalexin D / (+)-Oryzalexin D
C00034094	Oryzalexin F	CHEMBL254637 CHEMBL463903
C00034863	Isopimara-7,15-dien-2alpha-ol / (+)-Isopimara-7,15-dien-2alpha-ol
C00034864	Isopimara-7,15-dien-3beta-ol / (-)-Isopimara-7,15-dien-3beta-ol	CHEMBL225866
C00034866	Isopimara-7,15-diene
C00035989	Acanthoic acid / (-)-Acanthoic acid	CHEMBL152325 CHEMBL512490 CHEMBL523295		4 / 0 / 0
C00036008	3beta-Hydroxyisopimaric acid
C00037101	ent-8(14),15-sandaracopimaradiene-2alpha,18-diol / (+)-ent-8(14),15-sandaracopimaradiene-2alpha,18-diol
C00037105	ent-Pimara-8(14),15-dien-18-oic acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7
C00040774	17-Hydroxy-9-epi-ent-7,15-isopimaradiene
C00040775	19-Hydroxy-9-epi-ent-7,15-isopimaradiene
C00040777	19-Malonyl-9-epi-ent-7,15-isopimaradiene
C00041813	Sagittine A	CHEMBL447656
C00042933	Sandaracopimaradiene / (-)-Sandaracopimaradiene
C00048284	3beta-Acetoxy-7,15-isopimaradiene
C00048309	Akhdarenol
C00048379	ent-Pimara-8(14),15-diene / (-)-ent-Pimara-8(14),15-diene	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7
C00048512	Pimara-8(14),15-diene
C00049953	4-epi-Sandaracopimaric acid / (+)-4-epi-Sandaracopimaric acid	CHEMBL513197 CHEMBL1397211 CHEMBL1410398 CHEMBL1735595		14 / 13 / 7

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00003444 C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00003444 C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	2 / 0
O75496	Geminin	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003468 C00031283 C00037105 C00048379 C00049953	7 / 3
Q9Y253	DNA polymerase eta	Enzyme	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003468 C00031283 C00037105 C00048379 C00049953	1 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003468 C00031283 C00037105 C00048379 C00049953	0 / 0
P55055	Oxysterols receptor LXR-beta	NR1H3	C00035989	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00035989	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003444	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00035989	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00035989	0 / 0

9 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1386	ATF2, CRE-BP1, CREB2, HB16, TREB7	activating transcription factor 2 (EC:2.3.1.48)	C00003468
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00003468
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003468
3727	JUND, AP-1	jun D proto-oncogene	C00003468
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00003468
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00003468
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003468
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00003468
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003468

Related Diseases

Diseases related to proteins in ChEMBL interactions