KCF-S cluster No. 761 (11 metabolites)

Corresponding Phytochemical cluster No. 23

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	20
Spermatophyta	4
rosids	1
asterids	1

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Cumulative family count

class name	count
Magnoliaceae	16
Lauraceae	2
Schisandraceae	2
Cupressaceae	2
Taxaceae	2
Celastraceae	1
Lamiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Neolignans	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Neolignans	C10651	C00000591
Neolignans	C10630	C00002609
Neolignans	C10878	C00002622

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000591	Magnolol	CHEMBL180920	C005498	21 / 17 / 15	1 / 7
C00002609	Hinokiol / (+)-Hinokiol	CHEMBL16901		26 / 24 / 20
C00002622	Randainol
C00029537	4-Methoxyhonokiol / 4-O-Methyl honokiol
C00030707	Magnaldehyde B	CHEMBL250885
C00030708	Magnaldehyde E	CHEMBL251060
C00030709	Magnolignan C / (-)-Magnolignan C	CHEMBL399697
C00039166	erythro-Honokitriol / (-)-erythro-Honokitriol
C00039712	Magnolignan B
C00040143	Randaiol	CHEMBL555924
C00040486	threo-Honokitriol / (+)-threo-Honokitriol

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00000591 C00002609	1 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000591 C00002609	1 / 2
O00255	Menin	Unclassified protein	C00000591 C00002609	2 / 5
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000591 C00002609	1 / 1
Q9GZV3	High affinity choline transporter 1	Choline Na-symporter	C00000591 C00002609	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000591 C00002609	4 / 3
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000591 C00002609	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00000591 C00002609	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00000591 C00002609	1 / 1
P34972	Cannabinoid receptor 2	Cannabinoid receptor	C00000591 C00002609	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000591 C00002609	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000591 C00002609	2 / 0
O75496	Geminin	Unclassified protein	C00000591 C00002609	0 / 0
Q9Y2T6	G-protein coupled receptor 55	Lysophosphatidylinositol receptor	C00000591 C00002609	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002609	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002609	2 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00000591	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000591	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002609	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002609	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002609	5 / 3
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00002609	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000591	2 / 2
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000591	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002609	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002609	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00002609	4 / 2
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002609	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000591	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000591	0 / 0
P06746	DNA polymerase beta	Enzyme	C00002609	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002609	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000591	1 / 1

1 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00000591

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions