Tripterygium wilfordii

• Index
• Plant Species
• Metabolite list (49)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Tripterygium wilfordii
Genus	Tripterygium
Family	Celastraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Tripterygium wilfordii
Linked NCBI taxonomy ID	458696
Linked level	species

Family

Family in NCBI taxonomy	Celastraceae
ID	4305

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (49)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00000659	Medioresinol / (+)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1		No. 38	No. 21
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 38	No. 21
C00046516	Wilfornine E	CHEMBL450102				No. 43
C00046977	Wilfordinine B					No. 43
C00001987	Wilfordin	CHEMBL449308 CHEMBL525628				No. 43
C00046976	Wilfordinine A	CHEMBL2335702				No. 43
C00046846	Peritassine A / (+)-Peritassine A	CHEMBL1951082				No. 43
C00013107	Alatusinine / (8a)-8-(Acetyloxy)-8-deoxo-26-hydroxyevonimine	CHEMBL508998 CHEMBL501360				No. 43
C00013120	Evonine / [8R-(8R*,9R*,10R*,11S*,12S*,13R*,14R*,15S*,18S*,19S*,20S*,21S*)]-10,13,14,21-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,18,19-decahydro-20-hydroxy-8,18,19,20-tetramethyl-8,11-epoxy-9,12-ethano-11,15-methano-11H-[1,8]dioxacycloheptadecino[4,3-b]pyridine-5,17,22-trione	CHEMBL449845 CHEMBL1996226				No. 43
C00013126	Euonymin / Euonymine	CHEMBL346753 CHEMBL503447				No. 43
C00046518	Wilfornine G	CHEMBL502166				No. 43
C00046517	Wilfornine F	CHEMBL524497				No. 43
C00013158	Mayteine / [8R-(8R*,9R*,10R*,11S*,12S*,13R*,14R*,15S*,18S*,19S*,20S*,21S*,22R*)]-10,14,21,22-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-13-(benzoyloxy)-7,8,9,10,12,13,14,15,18,19-decahydro-20-hydroxy-8,18,19,20-tetramethyl-8,11-epoxy-9,12-ethano-11,15-methano-11H-[1,8]dioxacycloheptadecino[4,3-b]pyridine-5,17-dione	CHEMBL526919 CHEMBL1813072	C096143			No. 43
C00046978	Wilfordinine C					No. 43
C00013191	Wilforidine / (8R,9R,10R,11S,12S,13R,14R,15S,21S,22S,23R)-[partial]-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-14,18,21-trihydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17-dione	CHEMBL504312 CHEMBL1950977				No. 43
C00013193	Wilforine / (8alpha)-8-(Acetyloxy)-O2-benzoyl-O2-deacetyl-8-deoxoevonimine	CHEMBL503312 CHEMBL502742				No. 43
C00013194	Wilforzine / O6-Deacetylwilforine / ((8alpha)-8-(Acetyloxy)-O2-benzoyl-O2,O6-dideacetyl-8-deoxoevonimine					No. 43
C00046515	Wilfornine D					No. 43
C00046514	Wilfornine C	CHEMBL509162				No. 43
C00046513	Wilfornine B	CHEMBL525210				No. 43
C00039395	Hyponine D	CHEMBL504037				No. 43
C00041008	Hypoglaunine C / (+)-Hypoglaunine C	CHEMBL501891				No. 43
C00041944	Tripfordine A	CHEMBL504312 CHEMBL1950977				No. 43
C00041945	Tripfordine B	CHEMBL453463				No. 43
C00046511	Wilfordinine J	CHEMBL511075				No. 43
C00046512	Wilfornine A	CHEMBL502989				No. 43
C00046510	Wilfordinine I	CHEMBL508482				No. 43
C00041946	Tripfordine C	CHEMBL505030				No. 43
C00013156	Triptofordin D 1 / [3R-(3alpha,5alpha,5aalpha,6alpha,9beta,9aalpha,10R*)]-10-(Acetyloxy)-5a-[(acetyloxy)methyl]-5-(benzoyloxy)octahydro-9-hydroxy-2,2,9-trimethyl-4-oxo-2H-3,9a-methano-1-benzoxepin-6-yl ester 3-phenyl-2-propenoic acid					No. 168
C00013148	Triptofordin D 2 / [3R-(3alpha,4alpha,5alpha,5aalpha,6alpha,9beta,9aalpha,10R*)]-4,10-bis(Acetyloxy)-5a-[(acetyloxy)methyl]-5-(benzoyloxy)octahydro-9-hydroxy-2,2,9-trimethyl-2H-3,9a-methano-1-benzoxepin-6-yl ester 3-phenyl-2-propenoic acid					No. 168
C00049687	(-)-17-Hydroxy-16alpha-kauran-19-oic acid	CHEMBL511892 CHEMBL481645 CHEMBL448617 CHEMBL456957				No. 203	No. 41
C00049686	(-)-16alpha-Hydroxykauran-19-oic acid	CHEMBL207260 CHEMBL480070 CHEMBL604095 CHEMBL1760135	C060419	1 / 0 / 0		No. 203	No. 41
C00049689	16alpha,19-Dihydroxy-ent-kaurane	CHEMBL1760128				No. 203	No. 41
C00049759	Triptobenzene N / (-)-Triptobenzene N	CHEMBL444235				No. 355
C00049757	Triptobenzene L / (+)-Triptobenzene L					No. 359	No. 40
C00049755	Triptobenzene A					No. 760
C00049758	Triptobenzene M / (+)-Triptobenzene M					No. 760
C00002609	Hinokiol / (+)-Hinokiol	CHEMBL16901		26 / 24 / 20		No. 761	No. 23
C00041947	Tripterifordin	CHEMBL484043	C074970			No. 925
C00049760	Triptoquinone C					No. 1436
C00035883	Triptoquinone B					No. 1436
C00013189	Triptofordin A / (+)-Triptofordin A / [3R-(3alpha,5beta,5aalpha,6alpha,9beta,9aalpha)]-6-(Benzoyloxy)octahydro-9-hydroxy-2,2,5a,9-tetramethyl-2H-3,9a-methano-1-benzoxepin-5-yl ester 3-phenyl-2-propenoic acid					No. 1678
C00002322	Celabenzine					No. 2404
C00049756	Triptobenzene H					No. 2898
C00035770	Triptinin B / (+)-Triptinin B					No. 2898
C00003494	Triptolide	CHEMBL463763 CHEMBL444360	C001899	6 / 13 / 18	20 / 15	No. 3698	No. 41
C00003493	Tripdiolide	CHEMBL486403	C001898			No. 3698	No. 41
C00035774	Triptoquinone A		C100591			No. 4560
C00049761	Triptotin B / (+)-Triptotin B					No. 7621

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000659	1 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00049686	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002609	1 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002609	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003494	0 / 3
P06746	DNA polymerase beta	Enzyme	C00002609	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002609	1 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002609	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003494	11 / 10
P37840	Alpha-synuclein	Unclassified protein	C00002609	4 / 2
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002609	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00002609	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00002609	1 / 1
P11387	DNA topoisomerase 1	Isomerase	C00002631	0 / 0
P34972	Cannabinoid receptor 2	Cannabinoid receptor	C00002609	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002609	2 / 2
P39748	Flap endonuclease 1	Enzyme	C00002609	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002609	2 / 0
O75496	Geminin	Unclassified protein	C00002609	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003494	0 / 0
Q9Y2T6	G-protein coupled receptor 55	Lysophosphatidylinositol receptor	C00002609	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002609	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002609	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00002609	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002609	5 / 3
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00002609	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003494	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000659	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00002609	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002609	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002609	4 / 3
Q9GZV3	High affinity choline transporter 1	Choline Na-symporter	C00002609	1 / 0
O00255	Menin	Unclassified protein	C00002609	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002609	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00003494	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00003494	1 / 4

20 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00003494
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003494
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003494
941	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7	CD80 molecule	C00003494
942	CD86, B7-2, B7.2, B70, CD28LG2, LAB72	CD86 molecule	C00003494
1082	CGB, CGB3, CGB5, CGB7, CGB8, hCGB	chorionic gonadotropin, beta polypeptide	C00003494
1843	DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10	dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48)	C00003494
2146	EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2	enhancer of zeste homolog 2 (Drosophila) (EC:2.1.1.43)	C00003494
3303	HSPA1A, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1	heat shock 70kDa protein 1A	C00003494
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003494
3592	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	C00003494
3593	IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	C00003494
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00003494
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00003494
2908	NR3C1, GCCR, GCR, GR, GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	C00003494
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00003494
6839	SUV39H1, H3-K9-HMTase_1, KMT1A, MG44, SUV39H	suppressor of variegation 3-9 homolog 1 (Drosophila) (EC:2.1.1.43)	C00003494
6863	TAC1, Hs.2563, NK2, NKNA, NPK, TAC2	tachykinin, precursor 1	C00003494
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003494
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00003494

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions