KNApSAcK Metabolite C00003494
Metabolite
KNApSAcK Entry
| id | C00003494 |
|---|---|
| Name | Triptolide |
| CAS RN | 38748-32-2 |
| Standard InChI | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3 |
Cluster
| Phytochemical cluster | No. 41 |
|---|---|
| KCF-S cluster | No. 3698 |
Link
ChEMBL
| By standard InChI | CHEMBL463763 |
|---|---|
| By standard InChI Main Layer | CHEMBL463763 CHEMBL444360 |
KEGG
| By LinkDB | C09204 |
|---|
CTD
| By CAS RN | C001899 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Celastraceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Tripterygium wilfordii | 458696 | Celastraceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
6 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL463763 |
CHEMBL1008495
(1)
|
0 / 3 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL463763 |
CHEMBL1614544
(1)
|
11 / 10 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL463763 |
CHEMBL1613838
(1)
|
0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL463763 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL463763 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL463763 |
CHEMBL1613933
(1)
|
1 / 6 |
CTD interaction (25)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C001899 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | triptolide results in decreased expression of BIRC3 mRNA |
decreases expression
|
mRNA |
15972136
|
| C001899 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | triptolide results in increased activity of and results in increased cleavage of CASP3 protein |
increases activity
/ increases cleavage |
protein |
19233258
|
| C001899 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | triptolide results in increased activity of CASP3 protein |
increases activity
|
protein |
15972136
21640813 |
| C001899 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | triptolide results in increased activity of CASP7 protein |
increases activity
|
protein |
21640813
|
| C001899 | 941 |
CD80
B7 B7-1 B7.1 BB1 CD28LG CD28LG1 LAB7 |
CD80 molecule | triptolide results in decreased expression of CD80 protein |
decreases expression
|
protein |
15663903
|
| C001899 | 942 |
CD86
B7-2 B7.2 B70 CD28LG2 LAB72 |
CD86 molecule | triptolide results in decreased expression of CD86 protein |
decreases expression
|
protein |
15663903
|
| C001899 | 1082 |
CGB
CGB3 CGB5 CGB7 CGB8 hCGB |
chorionic gonadotropin, beta polypeptide | triptolide inhibits the reaction [CGB protein results in increased abundance of Progesterone] |
decreases reaction
/ increases abundance |
protein |
22592319
|
| C001899 | 1843 |
DUSP1
CL100 HVH1 MKP-1 MKP1 PTPN10 |
dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) | triptolide results in decreased expression of DUSP1 protein |
decreases expression
|
protein |
17507666
|
| C001899 | 2146 |
EZH2
ENX-1 ENX1 EZH1 EZH2b KMT6 KMT6A WVS WVS2 |
enhancer of zeste homolog 2 (Drosophila) (EC:2.1.1.43) | triptolide results in decreased expression of EZH2 protein |
decreases expression
|
protein |
19879315
|
| C001899 | 3303 |
HSPA1A
HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
heat shock 70kDa protein 1A | HSPA1A results in decreased susceptibility to triptolide |
decreases response to substance
|
19546256
|
|
| C001899 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | triptolide results in decreased expression of ICAM1 mRNA |
decreases expression
|
mRNA |
17931847
|
| C001899 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | triptolide results in decreased expression of ICAM1 protein |
decreases expression
|
protein |
17931847
|
| C001899 | 3592 |
IL12A
CLMF IL-12A NFSK NKSF1 P35 |
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | triptolide results in decreased expression of [IL12A protein binds to IL12B protein] |
affects binding
/ decreases expression |
protein |
15663903
|
| C001899 | 3593 |
IL12B
CLMF CLMF2 IL-12B NKSF NKSF2 |
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | triptolide results in decreased expression of [IL12A protein binds to IL12B protein] |
affects binding
/ decreases expression |
protein |
15663903
|
| C001899 | 3593 |
IL12B
CLMF CLMF2 IL-12B NKSF NKSF2 |
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | triptolide results in decreased expression of IL12B protein |
decreases expression
|
protein |
15663903
|
| C001899 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | triptolide inhibits the reaction [deoxynivalenol results in increased secretion of IL8 protein] |
decreases reaction
/ increases secretion |
protein |
20633634
|
| C001899 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | triptolide inhibits the reaction [TAC1 protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
20348278
|
| C001899 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | triptolide inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of MAPK14 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
17507666
|
| C001899 | 2908 |
NR3C1
GCCR GCR GR GRL |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | triptolide results in increased expression of and results in increased phosphorylation of NR3C1 protein |
increases expression
/ increases phosphorylation |
protein |
19330649
|
| C001899 | 2908 |
NR3C1
GCCR GCR GR GRL |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | triptolide results in increased expression of NR3C1 mRNA |
increases expression
|
mRNA |
19330649
|
| C001899 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | triptolide results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
15972136
|
| C001899 | 6839 |
SUV39H1
H3-K9-HMTase_1 KMT1A MG44 SUV39H |
suppressor of variegation 3-9 homolog 1 (Drosophila) (EC:2.1.1.43) | triptolide results in decreased expression of SUV39H1 protein |
decreases expression
|
protein |
19879315
|
| C001899 | 6863 |
TAC1
Hs.2563 NK2 NKNA NPK TAC2 |
tachykinin, precursor 1 | triptolide inhibits the reaction [TAC1 protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
20348278
|
| C001899 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | triptolide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
decreases reaction
/ increases secretion |
protein |
17678712
|
| C001899 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | [Idarubicin co-treated with triptolide] affects the expression of XIAP protein |
affects cotreatment
/ affects expression |
protein |
18922616
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (18)
| KEGG | disease name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
Diseases related to CTD interactions
15 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D058186 | C001899 | Acute Kidney Injury |
marker/mechanism
|
19546256
|
|
| D000855 | C001899 | Anorexia |
marker/mechanism
|
20223271
|
|
| D003967 | C001899 | Diarrhea |
marker/mechanism
|
20223271
|
|
| D056486 | C001899 | Drug-Induced Liver Injury |
marker/mechanism
|
19879934
|
|
| D005234 | C001899 | Fatty Liver |
marker/mechanism
|
20223271
|
|
| D007249 | C001899 | Inflammation |
therapeutic
|
21640813
|
|
| D007674 | C001899 | Kidney Diseases |
therapeutic
|
19879934
|
|
| D015470 | C001899 | Leukemia, Myeloid, Acute |
therapeutic
|
18922616
|
|
| D009101 | C001899 | Multiple Myeloma |
therapeutic
|
19330649
|
|
| D009102 | C001899 | Multiple Organ Failure |
marker/mechanism
|
21596114
|
|
| D009369 | C001899 | Neoplasms |
therapeutic
|
21640813
|
|
| D010049 | C001899 | Ovarian Diseases |
marker/mechanism
|
20223271
|
|
| D011014 | C001899 | Pneumonia |
therapeutic
|
20348278
|
|
| D011507 | C001899 | Proteinuria |
therapeutic
|
18509322
|
|
| D013163 | C001899 | Splenomegaly |
marker/mechanism
|
20223271
|