KCF-S cluster No. 3698 (3 metabolites)
Corresponding Phytochemical cluster No. 41
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 3 |
Cumulative family count
| class name | count |
|---|---|
| Celastraceae | 3 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
C00003493
|
Tripdiolide
|
CHEMBL486403
|
C001898
|
|
||
|
C00003494
|
Triptolide
|
CHEMBL463763
CHEMBL444360 |
C001899
|
6 / 13 / 18 | 20 / 15 |
|
|
C00034731
|
Triptriolide
|
|
Human Protein / Gene in interactions
6 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003494 | 0 / 3 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003494 | 11 / 10 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003494 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003494 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003494 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003494 | 1 / 4 |
20 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00003494
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003494
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003494
|
| 941 | CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 | CD80 molecule |
C00003494
|
| 942 | CD86, B7-2, B7.2, B70, CD28LG2, LAB72 | CD86 molecule |
C00003494
|
| 1082 | CGB, CGB3, CGB5, CGB7, CGB8, hCGB | chorionic gonadotropin, beta polypeptide |
C00003494
|
| 1843 | DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10 | dual specificity phosphatase 1 (EC:3.1.3.16 3.1.3.48) |
C00003494
|
| 2146 | EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2 | enhancer of zeste homolog 2 (Drosophila) (EC:2.1.1.43) |
C00003494
|
| 3303 | HSPA1A, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1 | heat shock 70kDa protein 1A |
C00003494
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003494
|
| 3592 | IL12A, CLMF, IL-12A, NFSK, NKSF1, P35 | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
C00003494
|
| 3593 | IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
C00003494
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00003494
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00003494
|
| 2908 | NR3C1, GCCR, GCR, GR, GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
C00003494
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003494
|
| 6839 | SUV39H1, H3-K9-HMTase_1, KMT1A, MG44, SUV39H | suppressor of variegation 3-9 homolog 1 (Drosophila) (EC:2.1.1.43) |
C00003494
|
| 6863 | TAC1, Hs.2563, NK2, NKNA, NPK, TAC2 | tachykinin, precursor 1 |
C00003494
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003494
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00003494
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (18)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058186 | Acute Kidney Injury |
C00003494
|
| D000855 | Anorexia |
C00003494
|
| D003967 | Diarrhea |
C00003494
|
| D056486 | Drug-Induced Liver Injury |
C00003494
|
| D005234 | Fatty Liver |
C00003494
|
| D007249 | Inflammation |
C00003494
|
| D007674 | Kidney Diseases |
C00003494
|
| D015470 | Leukemia, Myeloid, Acute |
C00003494
|
| D009101 | Multiple Myeloma |
C00003494
|
| D009102 | Multiple Organ Failure |
C00003494
|
| D009369 | Neoplasms |
C00003494
|
| D010049 | Ovarian Diseases |
C00003494
|
| D011014 | Pneumonia |
C00003494
|
| D011507 | Proteinuria |
C00003494
|
| D013163 | Splenomegaly |
C00003494
|