KCF-S cluster No. 203 (30 metabolites)

Corresponding Phytochemical cluster No. 41

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (30)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	11
rosids	11
Magnoliophyta	7

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Cumulative family count

class name	count
Annonaceae	7
Lamiaceae	4
Celastraceae	4
Euphorbiaceae	4
Rosaceae	3
Asteraceae	3
Apiaceae	1
Didymellaceae	1
Ericaceae	1
Plantaginaceae	1
Cordycipitaceae	1
Convolvulaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Aphidicolane	1
Tiglianes	1

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Aphidicolane	C06088	C00000873
Tiglianes	C09087	C00003423
Aphidicolane	C06088	C00023944

Metabolite list (30)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000873	Aphidicolin	CHEMBL12500 CHEMBL29711 CHEMBL485469 CHEMBL2006768	D016590	11 / 24 / 14	7 / 2
C00000887	Helifulvanic acid
C00000898	Stemarin
C00003423	Diterpenoid SP-II	CHEMBL490353 CHEMBL517155 CHEMBL519801 CHEMBL482613
C00023944	Aphidicolin / Aphidicolane-3alpha,16,17,18-tetraol	CHEMBL12500 CHEMBL29711 CHEMBL485469 CHEMBL2006768	D016590	11 / 24 / 14	7 / 2
C00023945	3-Deoxyaphidicolin		C037612
C00035038	Abbeokutone	CHEMBL437293
C00035596	Doianoterpene D / (-)-Doianoterpene D
C00037369	/ Kauranol / (-)-Kauran-16alpha-ol
C00037922	Trachyloban-18-oic acid / (-)-Trachyloban-18-oic acid	CHEMBL511801 CHEMBL463698 CHEMBL1164460		1 / 0 / 0
C00037923	Trachyloban-19-oic acid / (-)-Trachyloban-19-oic acid	CHEMBL511801 CHEMBL463698 CHEMBL1164460	C039978	1 / 0 / 0
C00038650	Broussonetone A / (-)-Broussonetone A	CHEMBL574312 CHEMBL574535
C00038651	Broussonetone B / (-)-Broussonetone B	CHEMBL574312 CHEMBL574535
C00038652	Broussonetone C / (-)-Broussonetone C
C00040103	Pterokaurane M3 / (-)-Pterokaurane M3
C00043944	Suremulol A / (-)-Suremulol A
C00044314	Siegesbeckiol
C00045520	16alpha,17-Dihydroxy-ent-kauran-19-oic acid / (-)-16alpha,17-Dihydroxy-ent-kauran-19-oic acid	CHEMBL490353 CHEMBL517155 CHEMBL519801 CHEMBL482613
C00045642	Annosquamosin B / (-)-Annosquamosin B	CHEMBL516819
C00045643	Annosquamosin C / (-)-Annosquamosin C
C00045647	Annosquamosin G
C00046613	Annoglabasin E / (-)-Annoglabasin E	CHEMBL1288269
C00047366	6beta,7beta,16alpha,17-Tetrahydroxy-ent-kauranoic acid / ent-6alpha,7alpha,16beta,17-Tetrahydroxykauranoic acid / (-)-6beta,7beta,16alpha,17-Tetrahydroxy-ent-kauranoic acid
C00048380	Epiadejone
C00048562	Vierol	CHEMBL1760128
C00049686	(-)-16alpha-Hydroxykauran-19-oic acid	CHEMBL207260 CHEMBL480070 CHEMBL604095 CHEMBL1760135	C060419	1 / 0 / 0
C00049687	(-)-17-Hydroxy-16alpha-kauran-19-oic acid	CHEMBL511892 CHEMBL481645 CHEMBL448617 CHEMBL456957
C00049689	16alpha,19-Dihydroxy-ent-kaurane	CHEMBL1760128
C00049850	16alpha,17-Dihydroxy-ent-kauran-19-oic acid / (-)-16alpha,17-Dihydroxy-ent-kauran-19-oic acid	CHEMBL490353 CHEMBL517155 CHEMBL519801 CHEMBL482613
C00049852	Annoglabasin B	CHEMBL490145 CHEMBL1288242

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000873 C00023944	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000873 C00023944	4 / 1
P06746	DNA polymerase beta	Enzyme	C00000873 C00023944	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000873 C00023944	11 / 10
P54098	DNA polymerase subunit gamma-1	Enzyme	C00000873 C00023944	6 / 2
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000873 C00023944	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000873 C00023944	0 / 0
P09884	DNA polymerase alpha catalytic subunit	Transferase	C00000873 C00023944	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000873 C00023944	0 / 0
P28340	DNA polymerase delta catalytic subunit	Transferase	C00000873 C00023944	2 / 0
Q07817	Bcl-2-like protein 1	Other cytosolic protein	C00037922 C00037923	0 / 0
P42858	Huntingtin	Unclassified protein	C00000873 C00023944	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00049686	0 / 0

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
890	CCNA2, CCN1, CCNA	cyclin A2	C00000873 C00023944
11200	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1	checkpoint kinase 2 (EC:2.7.11.1)	C00000873 C00023944
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00000873 C00023944
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00000873 C00023944
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00000873 C00023944
943	TNFRSF8, CD30, D1S166E, Ki-1	tumor necrosis factor receptor superfamily, member 8	C00000873 C00023944
7518	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	C00000873 C00023944

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions