KNApSAcK Metabolite C00000873
Metabolite
KNApSAcK Entry
| id | C00000873 |
|---|---|
| Name | Aphidicolin |
| CAS RN | 38966-21-1 |
| Standard InChI | InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14-,15-,16+,17-,18-,19-,20-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 41 |
|---|---|
| KCF-S cluster | No. 203 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL12500 CHEMBL29711 CHEMBL485469 CHEMBL2006768 |
KEGG
| By LinkDB | C06088 |
|---|
CTD
| By CAS RN | D016590 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Cordycipitaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Cephalosporium aphidicola | 291364 | Cordycipitaceae | Fungi |
Human Protein / Gene in interaction
11 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL29711 |
CHEMBL1613842
(2)
|
4 / 2 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL29711 |
CHEMBL1639858
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL29711 |
CHEMBL1614544
(1)
|
11 / 10 |
| P54098 | DNA polymerase subunit gamma-1 | Enzyme | CHEMBL29711 |
CHEMBL1639859
(1)
|
6 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL29711 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P42858 | Huntingtin | Unclassified protein | CHEMBL29711 |
CHEMBL1614156
(1)
|
1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | CHEMBL29711 |
CHEMBL646341
(1)
CHEMBL658013
(1)
CHEMBL884690 (1) CHEMBL1112810 (1) CHEMBL1639857 (1) |
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL29711 |
CHEMBL1614211
(1)
|
0 / 0 |
| P28340 | DNA polymerase delta catalytic subunit | Transferase | CHEMBL29711 |
CHEMBL884691
(1)
|
2 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL29711 |
CHEMBL1613829
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL29711 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (7)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D016590 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | Aphidicolin results in increased expression of CCNA2 mRNA |
increases expression
|
mRNA |
14738865
|
| D016590 | 11200 |
CHEK2
CDS1 CHK2 HuCds1 LFS2 PP1425 RAD53 hCds1 |
checkpoint kinase 2 (EC:2.7.11.1) | Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]] |
increases activity
/ increases phosphorylation / increases reaction |
protein |
18158334
|
| D016590 | 3014 |
H2AFX
H2A.X H2A/X H2AX |
H2A histone family, member X | Aphidicolin inhibits the reaction [docetaxel results in increased expression of H2AFX protein] |
decreases reaction
/ increases expression |
protein |
20878124
|
| D016590 | 5591 |
PRKDC
DNA-PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 |
protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) | Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]] |
increases activity
/ increases phosphorylation / increases reaction |
protein |
18158334
|
| D016590 | 6256 |
RXRA
NR2B1 |
retinoid X receptor, alpha | Aphidicolin results in increased expression of RXRA mRNA |
increases expression
|
mRNA |
14738865
|
| D016590 | 943 |
TNFRSF8
CD30 D1S166E Ki-1 |
tumor necrosis factor receptor superfamily, member 8 | Aphidicolin results in increased expression of TNFRSF8 protein |
increases expression
|
protein |
12441127
|
| D016590 | 7518 |
XRCC4
|
X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 results in decreased susceptibility to Aphidicolin |
decreases response to substance
|
21785230
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #612591 | Colorectal cancer, susceptibility to, 10; crcs10 |
P28340
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #256000 | Leigh syndrome; ls |
P54098
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #615381 | Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome; mdpl |
P28340
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #203700 | Mitochondrial dna depletion syndrome 4a (alpers type); mtdps4a |
P54098
|
| #613662 | Mitochondrial dna depletion syndrome 4b (mngie type); mtdps4b |
P54098
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #157640 | Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant, 1; peoa1 |
P54098
|
| #258450 | Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive; peob |
P54098
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607459 | Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis; sando |
P54098
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
KEGG DISEASE (14)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00469 | Mitochondrial DNA depletion syndrome (MDS) |
P54098
(related)
|
| H01118 | Progressive external ophthalmoplegia (PEO) |
P54098
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |