Verbena littoralis

• Index
• Plant Species
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Verbena littoralis
Genus	Verbena
Family	Verbenaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Verbena
Linked NCBI taxonomy ID	22002
Linked level	genus

Family

Family in NCBI taxonomy	Verbenaceae
ID	21910

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00013321	8,3'-Dihydroxy-5,7,4'-trimethoxyflavone / 8-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one					No. 3	No. 15
C00003850	8-Methoxyapigenin / 4'-Hydroxywogonin / Isoscutellarein 8-methyl ether / 5,7,4'-Trihydroxy-8-methoxyflavone	CHEMBL245712	C093385			No. 3	No. 15
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00030516	Isoacteoside / Isoverbascoside	CHEMBL504873	C064683	6 / 5 / 4		No. 33
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00045086	Stigmast-5-ene 3beta,4beta,7alpha,22alpha-tetraol	CHEMBL468236				No. 53	No. 11
C00029633	Ursolic acid / Acetylursolic acid	CHEMBL55086 CHEMBL410525		4 / 2 / 2		No. 177
C00014636	Littorachalcone					No. 375
C00014637	Verbenachalcone	CHEMBL519611				No. 375

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783 C00019064	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00019064 C00029633	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002783 C00019064	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064 C00029633	2 / 2
O75496	Geminin	Unclassified protein	C00002783 C00019064	0 / 0
P06746	DNA polymerase beta	Enzyme	C00019064 C00029633	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
P39900	Macrophage metalloelastase	M10A	C00030516	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00030516	2 / 2
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00019064	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002783	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00019064	0 / 3
P15121	Aldose reductase	Enzyme	C00019064	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
P03956	Interstitial collagenase	M10A	C00030516	0 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783	0 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
P45452	Collagenase 3	M10A	C00030516	1 / 1
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00030516	1 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064	0 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
Q99700	Ataxin-2	Unclassified protein	C00002783	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P08254	Stromelysin-1	M10A	C00030516	1 / 0
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00029633	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00019064	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00019064	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783	0 / 0

49 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783 C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783 C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783 C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783 C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783 C00019064
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
896	CCND3	cyclin D3	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00019064
847	CAT	catalase (EC:1.11.1.6)	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions