Plantago bellardi
Species
KNApSAcK Entry
| Organism name | Plantago bellardi |
|---|---|
| Genus | Plantago |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Plantago |
|---|---|
| Linked NCBI taxonomy ID | 26867 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002783
|
Kusaginin
/ Acteoside / Verbascoside |
CHEMBL231853
CHEMBL444478 CHEMBL1364101 |
C058956
|
12 / 1 / 1 | 34 / 3 | No. 33 |
|
|
|
C00010564
|
Geniposidic acid
|
CHEMBL460031
|
C058966
|
No. 100 | No. 36 |
|
||
|
C00003073
|
Aucubin
|
CHEMBL514882
CHEMBL1873725 CHEMBL1874462 |
C006650
|
5 / 1 / 1 | No. 100 | No. 36 |
|
|
|
C00003072
|
Asperuloside
|
CHEMBL461910
CHEMBL1965021 |
C077956
|
1 / 0 / 0 | No. 100 | No. 36 |
|
|
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
Human Protein / Gene in interactions
39 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00002724 C00002783 C00003073 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002783 C00003072 C00003073 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 C00002783 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002783 C00003073 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002724 C00002783 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002783 C00003073 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002724 C00002783 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002724 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002724 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002724 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002724 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002783 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002724 | 3 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002724 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002724 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002724 | 0 / 3 |
| P17252 | Protein kinase C alpha type | Alpha | C00002783 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002724 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002724 | 3 / 3 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00003073 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002724 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002724 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002783 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002724 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002724 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002724 | 0 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002783 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002724 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002783 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002724 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002724 | 1 / 0 |
71 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002783
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00002783
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002783
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002783
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00002783
|
| 896 | CCND3 | cyclin D3 |
C00002783
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002783
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00002783
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00002783
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00002783
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002783
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002783
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00002783
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002783
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00002783
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002783
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002783
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00002783
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002783
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002783
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00002783
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002783
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002783
|
| 27035 | NOX1, GP91-2, MOX1, NOH-1, NOH1 | NADPH oxidase 1 |
C00002783
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002783
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002783
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002783
|
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 |
C00002783
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00002783
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002783
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00002783
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00002783
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002783
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002783
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (21)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00002783
|
| D007938 | Leukemia |
C00002783
|
| D014947 | Wounds and Injuries |
C00002783
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D008545 | Melanoma |
C00002724
|
| D009336 | Necrosis |
C00002724
|
| D015431 | Weight Loss |
C00002724
|