Globularia trichosantha

• Index
• Plant Species
• Metabolite list (21)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Globularia trichosantha
Genus	Globularia
Family	Globulariaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Globularia trichosantha
Linked NCBI taxonomy ID	285841
Linked level	species

Family

Family in NCBI taxonomy	Plantaginaceae
ID	156152

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (21)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00046474	Trichosanthoside B / (-)-Trichosanthoside B	CHEMBL500194				No. 33
C00031192	Rossicaside A	CHEMBL459779				No. 33
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00030516	Isoacteoside / Isoverbascoside	CHEMBL504873	C064683	6 / 5 / 4		No. 33
C00034798	Arenarioside / Forsythoside F	CHEMBL506436 CHEMBL455827		1 / 0 / 3		No. 33
C00046473	Trichosanthoside A / (-)-Trichosanthoside A	CHEMBL506843				No. 33
C00046045	Isocrenatoside	CHEMBL402471		1 / 4 / 2		No. 33
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 38	No. 21
C00003075	Catalpol	CHEMBL513223	C078040	2 / 1 / 1	0 / 2	No. 64	No. 36
C00003073	Aucubin	CHEMBL514882 CHEMBL1873725 CHEMBL1874462	C006650	5 / 1 / 1		No. 100	No. 36
C00029749	Asperulosidic acid	CHEMBL389958				No. 100	No. 36
C00003072	Asperuloside	CHEMBL461910 CHEMBL1965021	C077956	1 / 0 / 0		No. 100	No. 36
C00010679	Scandoside	CHEMBL459415				No. 100	No. 36
C00010564	Geniposidic acid	CHEMBL460031	C058966			No. 100	No. 36
C00030092	Deacetylasperuloside / Deacetyl asperuloside	CHEMBL462113				No. 100	No. 36
C00010512	Globularidin					No. 120	No. 36
C00000723	Liriodendrin / Acanthoside D / (+)-Syringaresinol di-O-beta-glucopyranoside	CHEMBL446836 CHEMBL505393		2 / 2 / 2		No. 152
C00032701	Alpinoside / (-)-Alpinoside					No. 924
C00034797	Deacetylalpinoside / Arborescosidic acid / (-)-Arborescosidic acid					No. 924
C00045973	Globuloside B / (-)-Globuloside B					No. 1059
C00045972	Globuloside A / (-)-Globuloside A					No. 4441

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000723 C00002783 C00003073	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783 C00003072 C00003073	0 / 0
P03372	Estrogen receptor	NR3A1	C00003073 C00003075	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783 C00003073	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783 C00003073	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00002631	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00000723	2 / 2
P39748	Flap endonuclease 1	Enzyme	C00002783	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003075	0 / 0
P39900	Macrophage metalloelastase	M10A	C00030516	0 / 0
P03956	Interstitial collagenase	M10A	C00030516	0 / 1
P14780	Matrix metalloproteinase-9	M10A	C00030516	2 / 2
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
P45452	Collagenase 3	M10A	C00030516	1 / 1
P08253	72 kDa type IV collagenase	M10A	C00030516	1 / 3
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00034798	0 / 3
P12821	Angiotensin-converting enzyme	M2	C00046045	4 / 2
Q9UNA4	DNA polymerase iota	Enzyme	C00002783	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783	0 / 0
P08254	Stromelysin-1	M10A	C00030516	1 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783	0 / 0

34 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions