Barleria lupulina

• Index
• Plant Species
• Metabolite list (17)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Barleria lupulina
Genus	Barleria
Family	Acanthaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Barleria lupulina
Linked NCBI taxonomy ID	101743
Linked level	species

Family

Family in NCBI taxonomy	Acanthaceae
ID	4185

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (17)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00030317	Forsythoside B	CHEMBL393292		1 / 0 / 3		No. 33
C00031070	Poliumoside	CHEMBL499145		1 / 0 / 0		No. 33
C00010687	Shanzhiside methyl ester	CHEMBL1081414		1 / 1 / 1		No. 56	No. 36
C00010690	Barlerin / (-)-Barlerin / 8-O-Acetylshanzhiside methyl ester	CHEMBL463751 CHEMBL463377	C099473			No. 56	No. 36
C00010691	Acetylbarlerin					No. 56	No. 36
C00010692	6-O-Acetylshanzhiside methyl ester	CHEMBL2048640				No. 56	No. 36
C00010578	Ipolamiidoside					No. 56	No. 36
C00037621	Phlorigidoside B / (-)-Phlorigidoside B					No. 56	No. 36
C00036667	8-O-Acetylmussaenoside					No. 56	No. 36
C00003084	Ipolamiide					No. 56	No. 36
C00036313	(+)-Lyoniresinol 3alpha-O-beta-glucopyranoside / (+)-Lyoniresinol 3alpha-O-beta-D-glucopyranoside	CHEMBL464198 CHEMBL1159486 CHEMBL1159487 CHEMBL1813178 CHEMBL1813179 CHEMBL1813180 CHEMBL1813181 CHEMBL2332109		6 / 11 / 5		No. 174	No. 22
C00036666	8-O-Acetyl-6-O-trans-p-coumaroylshanzhiside					No. 213
C00037770	Saletpangponoside C / (-)-Saletpangponoside C					No. 243
C00036345	(3R)-1-Octen-3-yl-beta-primeveroside	CHEMBL460125				No. 565	No. 73
C00037769	Saletpangponoside B / (-)-Saletpangponoside B					No. 1582
C00037768	Saletpangponoside A / (-)-Saletpangponoside A					No. 1582

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P17252	Protein kinase C alpha type	Alpha	C00002783 C00031070	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783 C00036313	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00036313	7 / 3
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00030317	0 / 3
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00036313	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00036313	0 / 0
P60033	CD81 antigen	Unclassified protein	C00010687	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00002783	0 / 0
O75496	Geminin	Unclassified protein	C00002783	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783	0 / 0
Q9P0U3	Sentrin-specific protease 1	Enzyme	C00036313	0 / 0
P00734	Prothrombin	S1A	C00036313	4 / 2
Q9UNA4	DNA polymerase iota	Enzyme	C00002783	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783	0 / 0

34 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions