Scrophularia nodosa L.
Species
KNApSAcK Entry
| Organism name | Scrophularia nodosa L. |
|---|---|
| Genus | Scrophularia |
| Family | Scrophulariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Scrophularia nodosa |
|---|---|
| Linked NCBI taxonomy ID | 90363 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Scrophulariaceae |
|---|---|
| ID | 4149 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (12)
| Species | Activity |
|---|---|
| Scrophularia nodosa L. | Alterative |
| Scrophularia nodosa L. | Analgesic |
| Scrophularia nodosa L. | Antiinflammatory |
| Scrophularia nodosa L. | Depurative |
| Scrophularia nodosa L. | Diuretic |
| Scrophularia nodosa L. | Hypotensive |
| Scrophularia nodosa L. | Laxative |
| Scrophularia nodosa L. | Myocardiocontractant |
| Scrophularia nodosa L. | Narcotic |
| Scrophularia nodosa L. | Sedative |
| Scrophularia nodosa L. | Vermifuge |
| Scrophularia nodosa L. | Vulnerary |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002783
|
Kusaginin
/ Acteoside / Verbascoside |
CHEMBL231853
CHEMBL444478 CHEMBL1364101 |
C058956
|
12 / 1 / 1 | 34 / 3 | No. 33 |
|
|
|
C00049600
|
Scrophuloside B2
/ (-)-Scrophuloside B2 |
No. 33 |
|
|||||
|
C00049599
|
Scrophuloside B1
/ (-)-Scrophuloside B1 |
No. 33 |
|
|||||
|
C00034563
|
Jionoside D
|
CHEMBL555710
|
No. 33 |
|
||||
|
C00049587
|
cis-Acteoside
|
CHEMBL231853
CHEMBL444478 CHEMBL1364101 |
12 / 1 / 1 | No. 33 |
|
|||
|
C00035177
|
Angoroside C
|
C413578
|
No. 33 |
|
||||
|
C00049586
|
Angoroside A
|
CHEMBL506436
CHEMBL455827 |
1 / 0 / 3 | No. 33 |
|
|||
|
C00036075
|
Buddlejoside A3
|
No. 189 |
|
|||||
|
C00036076
|
Buddlejoside A4
|
CHEMBL1779144
|
No. 189 |
|
||||
|
C00036077
|
Buddlejoside A5
|
No. 189 |
|
|||||
|
C00034914
|
Verbascoside A
/ (-)-Verbascoside A |
No. 189 |
|
|||||
|
C00034892
|
Scrovalentinoside
|
No. 189 |
|
|||||
|
C00049592
|
Pulverulentoside II
|
No. 189 |
|
|||||
|
C00034225
|
Scrophuloside A3
/ (-)-Scrophuloside A3 |
No. 189 |
|
|||||
|
C00049595
|
Scrophuloside A5
/ (+)-Scrophuloside A5 |
No. 189 |
|
|||||
|
C00049596
|
Scrophuloside A6
/ (-)-Scrophuloside A6 |
No. 189 |
|
|||||
|
C00049597
|
Scrophuloside A7
|
No. 189 |
|
|||||
|
C00049598
|
Scrophuloside A8
/ (-)-Scrophuloside A8 |
No. 189 |
|
|||||
|
C00034224
|
Scrophuloside A2
/ (-)-Scrophuloside A2 |
No. 189 |
|
|||||
|
C00049594
|
Scrophuloside A1
/ (-)-Scrophuloside A1 |
No. 213 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002783 C00049587 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002783 C00049587 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002783 C00049587 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002783 C00049587 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002783 C00049587 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002783 C00049587 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002783 C00049587 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002783 C00049587 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002783 C00049587 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002783 C00049587 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002783 C00049587 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002783 C00049587 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00049586 | 0 / 3 |
34 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002783
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00002783
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002783
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002783
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00002783
|
| 896 | CCND3 | cyclin D3 |
C00002783
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002783
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00002783
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00002783
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00002783
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002783
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002783
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00002783
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002783
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00002783
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002783
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002783
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00002783
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002783
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002783
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00002783
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002783
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002783
|
| 27035 | NOX1, GP91-2, MOX1, NOH-1, NOH1 | NADPH oxidase 1 |
C00002783
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002783
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002783
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002783
|
| 4087 | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 | SMAD family member 2 |
C00002783
|
| 4088 | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 | SMAD family member 3 |
C00002783
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002783
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00002783
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00002783
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002783
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002783
|