Species

KNApSAcK Entry

Organism name Fernandoa adenophylla
Genus Fernandoa
Family Bignoniaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fernandoa
Linked NCBI taxonomy ID 260310
Linked level genus

Family

Family in NCBI taxonomy Bignoniaceae
ID 24079

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004232 External link 512 Hispidulin 7-glucuronide
/ Hispidulin 7-O-beta-glucuronide
/ (-)-Hispidulin 7-O-beta-glucuronide
No. 2 No. 15
C00004144 External link 512 Apigenin 7-glucuronide
/ Apigenin 7-O-beta-D-glucuronide
/ (-)-Apigenin 7-O-beta-D-glucuronide
CHEMBL254213
CHEMBL1980748
No. 2 No. 15
C00004231 External link 512 Hispidulin 7-glucoside
/ Hispidulin 7-O-beta-glucoside
/ (-)-Hispidulin 7-O-beta-glucoside
/ Hispidulin-7-O-beta-D-glucopyranoside
CHEMBL480657
No. 2 No. 15
C00002783 External link 512 Kusaginin
/ Acteoside
/ Verbascoside
CHEMBL231853
CHEMBL444478
CHEMBL1364101
C058956
12 / 1 / 1 34 / 3 No. 33
C00030516 External link 512 Isoacteoside
/ Isoverbascoside
CHEMBL504873
C064683
6 / 5 / 4 No. 33
C00034597 External link 512 Martynoside
CHEMBL234764
CHEMBL503531
CHEMBL2134071
1 / 7 / 3 No. 33
C00036501 External link 512 O-Apiosylverbascoside
/ 2''-O-beta-Apiosylverbascoside
No. 33
C00030657 External link 512 Leucosceptoside A
CHEMBL450121
1 / 0 / 0 No. 33
C00031274 External link 512 Salidroside
/ Rhodioloside
/ (-)-Rhodioloside
/ Tyrosol alpha-(beta-D-glucopyranoside)
CHEMBL465208
CHEMBL1899113
C009172
3 / 0 / 0 No. 45 No. 72
C00036313 External link 512 (+)-Lyoniresinol 3alpha-O-beta-glucopyranoside
/ (+)-Lyoniresinol 3alpha-O-beta-D-glucopyranoside
CHEMBL464198
CHEMBL1159486
CHEMBL1159487
CHEMBL1813178
CHEMBL1813179
CHEMBL1813180
CHEMBL1813181
CHEMBL2332109
6 / 11 / 5 No. 174 No. 22
C00037137 External link 512 Fernandoside
/ (+)-Fernandoside
No. 1230

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17252 Protein kinase C alpha type Alpha C00002783 C00030657 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002783 C00036313 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002783 C00031274 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00034597 C00036313 7 / 3
O75496 Geminin Unclassified protein C00002783 C00031274 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002783 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00036313 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00031274 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002783 0 / 0
P39900 Macrophage metalloelastase M10A C00030516 0 / 0
P03956 Interstitial collagenase M10A C00030516 0 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00036313 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00030516 2 / 2
Q99700 Ataxin-2 Unclassified protein C00002783 1 / 1
Q9P0U3 Sentrin-specific protease 1 Enzyme C00036313 0 / 0
P00734 Prothrombin S1A C00036313 4 / 2
P45452 Collagenase 3 M10A C00030516 1 / 1
P08253 72 kDa type IV collagenase M10A C00030516 1 / 3
Q9UNA4 DNA polymerase iota Enzyme C00002783 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002783 0 / 0
P08254 Stromelysin-1 M10A C00030516 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002783 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002783 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002783 0 / 0

34 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002783
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00002783
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002783
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002783
894 CCND2, KIAK0002 cyclin D2 C00002783
896 CCND3 cyclin D3 C00002783
898 CCNE1, CCNE cyclin E1 C00002783
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002783
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002783
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002783
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002783
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002783
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002783
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002783
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00002783
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002783
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002783
3458 IFNG, IFG, IFI interferon, gamma C00002783
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002783
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002783
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002783
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002783
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002783
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00002783
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002783
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002783
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002783
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002783
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00002783
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002783
7039 TGFA, TFGA transforming growth factor, alpha C00002783
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00002783
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002783
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#603932 Intervertebral disc disease; idd P14780
#174800 Mccune-albright syndrome; mas P63092
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (10)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007249 Inflammation C00002783
D007938 Leukemia C00002783
D014947 Wounds and Injuries C00002783