Species

KNApSAcK Entry

Organism name Stachys lanata
Genus Stachys
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stachys
Linked NCBI taxonomy ID 53171
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (30)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001017 External link 512 Cosmosiin
/ Apigenin 7-glucoside
/ (-)-Apigenin 7-glucoside
/ Apigenin 7-O-beta-D-glucopyranoside
CHEMBL487995
CHEMBL487017
CHEMBL1591566
CHEMBL2165585
C057792
5 / 6 / 1 No. 2 No. 15
C00038476 External link 512 Apigenin 7-O-(6-O-p-(Z)-coumaroyl)-beta-D-glucopyranoside
No. 30 No. 15
C00038475 External link 512 Apigenin 7-O-(3-O-p-(Z)-coumaroyl)-beta-D-glucopyranoside
CHEMBL234317
No. 30 No. 15
C00004172 External link 512 Echinacin
/ (-)-Echinacin
/ Apigenin 7-O-p-coumaroylglucoside
/ Apigenin 7-(6''-p-coumarylglucoside)
/ Apigenin 7-O-(6''-O-p-coumaroylglucoside)
C084441
No. 30 No. 15
C00002783 External link 512 Kusaginin
/ Acteoside
/ Verbascoside
CHEMBL231853
CHEMBL444478
CHEMBL1364101
C058956
12 / 1 / 1 34 / 3 No. 33
C00036871 External link 512 Campneoside I
No. 33
C00039615 External link 512 Leonoside B
CHEMBL428306
No. 33
C00038693 External link 512 Campneoside II
/ (-)-Campneoside II
No. 33
C00040370 External link 512 Stachysoside B
CHEMBL436809
CHEMBL595544
No. 33
C00030516 External link 512 Isoacteoside
/ Isoverbascoside
CHEMBL504873
C064683
6 / 5 / 4 No. 33
C00034597 External link 512 Martynoside
CHEMBL234764
CHEMBL503531
CHEMBL2134071
1 / 7 / 3 No. 33
C00029684 External link 512 Androsin
CHEMBL481234
C071696
No. 45 No. 72
C00031274 External link 512 Salidroside
/ Rhodioloside
/ (-)-Rhodioloside
/ Tyrosol alpha-(beta-D-glucopyranoside)
CHEMBL465208
CHEMBL1899113
C009172
3 / 0 / 0 No. 45 No. 72
C00039839 External link 512 Neolloydosin
No. 128 No. 72
C00030098 External link 512 Verbasoside
/ (-)-Verbasoside
/ Decaffeoylverbascoside
/ (-)-Decaffeoylverbascoside
CHEMBL1779146
No. 128 No. 72
C00037004 External link 512 Darendoside B
CHEMBL462940
C080861
No. 128 No. 72
C00004186 External link 512 Anisofolin A
/ Apigenin 7-(3'',6''-di-p-coumarylglucoside)
No. 231
C00029980 External link 512 Citroside A
/ (-)-Citroside A
CHEMBL1814429
No. 316
C00040373 External link 512 Stachysoside G
/ (-)-Stachysoside G
No. 458
C00040371 External link 512 Stachysoside E
/ (-)-Stachysoside E
No. 458
C00040372 External link 512 Stachysoside F
/ (-)-Stachysoside F
No. 458
C00040374 External link 512 Stachysoside H
/ (+)-Stachysoside H
No. 458
C00039279 External link 512 Glucoacetosyringone
CHEMBL517838
CHEMBL516755
No. 678 No. 6
C00002727 External link 512 Coniferin
/ Coniferoside
CHEMBL459056
C016316
2 / 0 / 0 No. 678 No. 6
C00000010 External link 512 Syringin
CHEMBL250872
C028305
1 / 0 / 0 0 / 1 No. 678 No. 6
C00002074 External link 512 Stachydrine
CHEMBL394450
CHEMBL1456892
CHEMBL1986864
10 / 8 / 12 No. 2627 No. 1
C00029834 External link 512 Vomifoliol
/ Blumenol A
/ (+)-Blumenol A
/ Roseoside aglycon
CHEMBL463088
No. 3492
C00029298 External link 512 Dehydrovomifoliol
/ (+)-Dehydrovomifoliol
/ S-(+)-Dehydrovomifoliol
CHEMBL461278
No. 3492
C00013730 External link 512 Stachysetin
No. 5339
C00035259 External link 512 Cistanoside F
No. 6662

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein C00001017 C00002783 C00031274 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000010 C00002727 C00031274 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001017 C00002074 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001017 C00002783 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002727 C00002783 0 / 0
O75496 Geminin Unclassified protein C00002783 C00031274 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002074 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002074 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002074 0 / 1
P39900 Macrophage metalloelastase M10A C00030516 0 / 0
P17252 Protein kinase C alpha type Alpha C00002783 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002074 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002783 1 / 1
P03956 Interstitial collagenase M10A C00030516 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00034597 7 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002783 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00030516 2 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002783 0 / 0
P45452 Collagenase 3 M10A C00030516 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002074 0 / 0
P08253 72 kDa type IV collagenase M10A C00030516 1 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001017 2 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002074 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002074 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002783 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002783 0 / 0
P08254 Stromelysin-1 M10A C00030516 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001017 4 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002783 0 / 0
O00255 Menin Unclassified protein C00002074 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002074 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002783 0 / 0

34 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002783
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00002783
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002783
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002783
894 CCND2, KIAK0002 cyclin D2 C00002783
896 CCND3 cyclin D3 C00002783
898 CCNE1, CCNE cyclin E1 C00002783
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002783
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002783
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002783
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002783
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002783
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002783
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002783
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00002783
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002783
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002783
3458 IFNG, IFG, IFI interferon, gamma C00002783
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002783
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002783
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002783
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002783
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002783
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00002783
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002783
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002783
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002783
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002783
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00002783
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002783
7039 TGFA, TFGA transforming growth factor, alpha C00002783
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00002783
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002783
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002783

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614490 Blood group, junior system; jr Q9UNQ0
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#174800 Mccune-albright syndrome; mas P63092
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (21)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001862 Bone Resorption C00000010
D007249 Inflammation C00002783
D007938 Leukemia C00002783
D014947 Wounds and Injuries C00002783