Lippia dulcis TREV.

• Index
• Plant Species
• Metabolite list (12)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Lippia dulcis TREV.
Genus	Lippia
Family	Verbenaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Lippia
Linked NCBI taxonomy ID	320344
Linked level	genus

Family

Family in NCBI taxonomy	Verbenaceae
ID	21910

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (12)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003894	Eupatorin / 3',5-Dihydroxy-4',6,7-trimethoxyflavone / 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one	CHEMBL487402	C103110	5 / 5 / 4	5 / 0	No. 3	No. 15
C00003837	Cirsimaritin	CHEMBL348436	C007072	13 / 18 / 14		No. 3	No. 15
C00003947	5,3'-Dihydroxy-6,7,4',5'-tetramethoxyflavone / 5-Hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one					No. 8	No. 15
C00003898	5-Hydroxy-6,7,3',4'-tetramethoxyflavone / 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether / 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one	CHEMBL226508	C045324			No. 8	No. 15
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00030516	Isoacteoside / Isoverbascoside	CHEMBL504873	C064683	6 / 5 / 4		No. 33
C00003840	Salvigenin	CHEMBL376644	C014049			No. 35	No. 15
C00010590	Lamiide					No. 56	No. 36
C00035981	8-Epiloganin	CHEMBL1081584 CHEMBL1081586 CHEMBL1589904 CHEMBL2135791		2 / 1 / 1		No. 56	No. 36
C00030098	Verbasoside / (-)-Verbasoside / Decaffeoylverbascoside / (-)-Decaffeoylverbascoside	CHEMBL1779146				No. 128	No. 72
C00031768	Epilippidulcine A / (-)-Epilippidulcine A					No. 3312
C00031981	Lippidulcine A					No. 3312

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783 C00003837	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002783 C00003837	0 / 0
O75496	Geminin	Unclassified protein	C00002783 C00035981	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003837	7 / 3
P06746	DNA polymerase beta	Enzyme	C00003837	0 / 0
P04062	Glucosylceramidase	Enzyme	C00003837	6 / 4
P17252	Protein kinase C alpha type	Alpha	C00002783	0 / 0
P39900	Macrophage metalloelastase	M10A	C00030516	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00030516	2 / 2
O14965	Aurora kinase A	Aur	C00003894	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00003894	0 / 0
P60033	CD81 antigen	Unclassified protein	C00035981	1 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003837	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002783	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003837	0 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003837	0 / 0
P03956	Interstitial collagenase	M10A	C00030516	0 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00003837	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00003837	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002783	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00003894	4 / 4
Q96GD4	Aurora kinase B	Aur	C00003894	0 / 0
P35968	Vascular endothelial growth factor receptor 2	Vegfr	C00003894	1 / 0
P45452	Collagenase 3	M10A	C00030516	1 / 1
P08253	72 kDa type IV collagenase	M10A	C00030516	1 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003837	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00002783	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003837	4 / 3
P08254	Stromelysin-1	M10A	C00030516	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002783	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00003837	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783	0 / 0

38 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002783 C00003894
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002783
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002783
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002783
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00003894
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00003894
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00003894
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00003894

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions