PCIDB

KNApSAcK Metabolite C00001029

Metabolite

KNApSAcK Entry

id C00001029
Name Chrysoeriol / Luteolin 3'-methyl ether
CAS RN 491-71-4
Standard InChI InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL214321
By standard InChI Main Layer CHEMBL214321

KEGG

By LinkDB C04293

CTD

By CAS RN C007054

Species

Summary

Plant class

class name count
rosids 16
asterids 16
Embryophyta 2
Liliopsida 2
Euphyllophyta 1

Family (Top 10)

family name count
Fabaceae 15
Lamiaceae 8
Asteraceae 4
Poaceae 1
Bignoniaceae 1
Cannabaceae 1
Scrophulariaceae 1
Apiaceae 1
Conocephalaceae 1
Riellaceae 1

List (39)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Apium graveolens 4045 Apiaceae asterids Viridiplantae
Arachis hypogaea 3818 Fabaceae rosids Viridiplantae
Asphodeline globifera 49695 Xanthorrhoeaceae Liliopsida Viridiplantae
Bauhinia guianensis 508984 Fabaceae rosids Viridiplantae
Cadia purpurea 53844 Fabaceae rosids Viridiplantae
Cannabis sativa L. 3483 Cannabaceae rosids Viridiplantae
Coleus amboinicus 587658 Lamiaceae asterids Viridiplantae
Conocephalum conicum 41839 Conocephalaceae Embryophyta Viridiplantae
Echinop ritro
Eriodictyon glutinosum 4131 Hydrophyllaceae asterids Viridiplantae
Gutierrezia wrightii 71047 Asteraceae asterids Viridiplantae
Hymenaea palustris Ducke 20675 Fabaceae rosids Viridiplantae
Leucas aspera 483811 Lamiaceae asterids Viridiplantae
Lotus maritimus 118937 Fabaceae rosids Viridiplantae
Marrubium velutinum 41229 Lamiaceae asterids Viridiplantae
Medicago intertexta 70950 Fabaceae rosids Viridiplantae
Medicago marina 66815 Fabaceae rosids Viridiplantae
Medicago sativa 3879 Fabaceae rosids Viridiplantae
Myoporum bontioides 57115 Scrophulariaceae asterids Viridiplantae
Newbouldia laevis 211924 Bignoniaceae asterids Viridiplantae
Notholaena californica 414628 Pteridaceae Euphyllophyta Viridiplantae
Onopordum acanthium 92915 Asteraceae asterids Viridiplantae
Parkinsonia aculeata 58886 Fabaceae rosids Viridiplantae
Riella affinis
Riella americana 122650 Riellaceae Embryophyta Viridiplantae
Salvia candidissima 268896 Lamiaceae asterids Viridiplantae
Salvia dorrii 207754 Lamiaceae asterids Viridiplantae
Salvia lavandulaefolia 49214 Lamiaceae asterids Viridiplantae
Salvia mirzayana 21880 Lamiaceae asterids Viridiplantae
Salvia palaestina 268920 Lamiaceae asterids Viridiplantae
Tanacetum parthenium (L.) Schulz Bip. 99105 Asteraceae asterids Viridiplantae
Tanacetum vulgare L. 128002 Asteraceae asterids Viridiplantae
Tephrosia toxicaria 3803 Fabaceae rosids Viridiplantae
Thermopsis alterniflora 49852 Fabaceae rosids Viridiplantae
Thermopsis macrophylla 114322 Fabaceae rosids Viridiplantae
Thermopsis mollis 49852 Fabaceae rosids Viridiplantae
Thermopsis rhombifolia 61122 Fabaceae rosids Viridiplantae
Thermopsis villosa 114325 Fabaceae rosids Viridiplantae
Zea mays L. 4577 Poaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL214321 CHEMBL1062295 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL214321 CHEMBL1614079 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL214321 CHEMBL2341203 (1) CHEMBL2341207 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL214321 CHEMBL1794585 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL214321 CHEMBL1225717 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL214321 CHEMBL1614166 (1)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL214321 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL214321 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL214321 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL214321 CHEMBL2114843 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL214321 CHEMBL2114807 (1)
4 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL214321 CHEMBL1614257 (2) CHEMBL1614410 (1)
CHEMBL1614531 (2)
1 / 3
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL214321 CHEMBL1059360 (1) CHEMBL1059361 (1)
5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL214321 CHEMBL1225718 (1)
4 / 4
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL214321 CHEMBL1225716 (1)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL214321 CHEMBL1062296 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL214321 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL214321 CHEMBL1614421 (1)
4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL214321 CHEMBL1059364 (1) CHEMBL1059365 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL214321 CHEMBL1614257 (2) CHEMBL1614531 (2)
2 / 5

CTD interaction (11)

compound gene gene name gene description interaction interaction type form reference
pmid
C007054 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 chrysoeriol results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C007054 196 AHR
bHLHe76
aryl hydrocarbon receptor chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] affects binding
/ decreases reaction
protein 20553787
C007054 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 20553787
C007054 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] decreases reaction
/ increases expression
mRNA 20553787
C007054 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] decreases reaction
/ increases expression
mRNA 20553787
C007054 4543 MTNR1A
MEL-1A-R
MT1
melatonin receptor 1A chrysoeriol binds to MTNR1A protein affects binding
protein 20399199
C007054 4544 MTNR1B
FGQTL2
MEL-1B-R
MT2
melatonin receptor 1B chrysoeriol binds to MTNR1B protein affects binding
protein 20399199
C007054 4835 NQO2
DHQV
DIA6
NMOR2
QR2
NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2] decreases reaction
/ increases oxidation
/ increases reduction
protein 20399199
C007054 4835 NQO2
DHQV
DIA6
NMOR2
QR2
NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3] decreases reaction
/ increases oxidation
/ increases reduction
protein 20399199
C007054 4835 NQO2
DHQV
DIA6
NMOR2
QR2
NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2] decreases reaction
/ increases oxidation
/ increases reduction
protein 20399199
C007054 4835 NQO2
DHQV
DIA6
NMOR2
QR2
NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] decreases reaction
/ increases oxidation
/ increases reduction
protein 20399199

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#237500 Dubin-johnson syndrome; djs Q92887
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (20)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)