Conocephalum conicum
Species
KNApSAcK Entry
| Organism name | Conocephalum conicum |
|---|---|
| Genus | Conocephalum |
| Family | Conocephalaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Conocephalum conicum |
|---|---|
| Linked NCBI taxonomy ID | 41839 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Conocephalaceae |
|---|---|
| ID | 41837 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Embryophyta |
|---|---|
| ID | 3193 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006236
|
Isoviolanthin
|
No. 1 | No. 15 |
|
||||
|
C00004350
|
Luteolin 3'-methyl ether 7-glucuronide-4'-rhamnoside
|
No. 1 | No. 15 |
|
||||
|
C00004164
|
Apigenin 7-glucuronide-4'-rhamnoside
|
No. 1 | No. 15 |
|
||||
|
C00004296
|
Luteolin 7-glucuronide-4'-rhamnoside
|
No. 1 | No. 15 |
|
||||
|
C00004266
|
Cinaroside
/ Luteolin 7-glucoside / Luteolin-7-O-glucoside / Luteolin 7-O-beta-D-glucopyranoside |
CHEMBL233929
CHEMBL574683 CHEMBL1159535 CHEMBL1317166 |
C066408
|
26 / 31 / 53 | No. 2 | No. 15 |
|
|
|
C00001017
|
Cosmosiin
/ Apigenin 7-glucoside / (-)-Apigenin 7-glucoside / Apigenin 7-O-beta-D-glucopyranoside |
CHEMBL487995
CHEMBL487017 CHEMBL1591566 CHEMBL2165585 |
C057792
|
5 / 6 / 1 | No. 2 | No. 15 |
|
|
|
C00001029
|
Chrysoeriol
/ Luteolin 3'-methyl ether |
CHEMBL214321
|
C007054
|
20 / 24 / 20 | 8 / 0 | No. 3 | No. 15 |
|
|
C00004308
|
Luteolin 7-glucuronide-3',4'-dirhamnoside
|
No. 5 | No. 15 |
|
||||
|
C00040069
|
Presilphiperfolan-1-ol
/ (-)-Presilphiperfolan-1-ol |
No. 161 | No. 38 |
|
||||
|
C00038050
|
(-)-Aromadendran-5-ol
|
No. 197 | No. 38 |
|
||||
|
C00020510
|
8alpha-Acetoxyzaluzanin C
|
No. 206 | No. 38 |
|
||||
|
C00020506
|
8alpha-Acetoxyzaluzanin D
|
No. 206 | No. 38 |
|
||||
|
C00030187
|
(-)-Leden
/ ent-Ledene / (-)-Ledene |
No. 595 | No. 38 |
|
||||
|
C00038073
|
(+)-Aromadendr-4-en-12-ol
|
No. 595 | No. 38 |
|
||||
|
C00038071
|
(+)-alpha-Gurjunene
|
No. 595 | No. 38 |
|
||||
|
C00012425
|
Bicyclogermacren
/ Bicyclogermacrene / (+)-Bicyclogermacrene |
CHEMBL509566
|
No. 699 | No. 38 |
|
|||
|
C00012424
|
13-Bicyclogermacrenal
/ [1R-(1R*,2E,6E,10S*,11S*)]-3,7,11-Trimethylbicyclo[8.1.0]undeca-2,6-diene-11-carboxaldehyde |
No. 699 | No. 38 |
|
||||
|
C00011053
|
(-)-Sabinene
/ (-)-4(10)-Thujene |
CHEMBL452687
|
No. 1343 | No. 35 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001029 C00004266 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001029 C00004266 | 2 / 5 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001017 C00004266 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001029 C00004266 | 4 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001029 C00004266 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001029 C00004266 | 1 / 2 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001029 C00004266 | 4 / 2 |
| O75496 | Geminin | Unclassified protein | C00001029 C00004266 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001029 C00004266 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001029 C00004266 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00004266 | 4 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001029 | 2 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00001029 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001029 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00004266 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00004266 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001029 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001017 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00004266 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001017 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001029 | 1 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001029 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00001029 | 4 / 4 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001029 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00004266 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001017 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001029 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001029 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00004266 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00004266 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00004266 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00004266 | 1 / 1 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001029 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001017 | 4 / 1 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00004266 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00004266 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00004266 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00004266 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00004266 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00004266 | 7 / 37 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00004266 | 2 / 1 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001029
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001029
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001029
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001029
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001029
|
| 4543 | MTNR1A, MEL-1A-R, MT1 | melatonin receptor 1A |
C00001029
|
| 4544 | MTNR1B, FGQTL2, MEL-1B-R, MT2 | melatonin receptor 1B |
C00001029
|
| 4835 | NQO2, DHQV, DIA6, NMOR2, QR2 | NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) |
C00001029
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (48)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|