PCIDB

KNApSAcK Metabolite C00004266

Metabolite

KNApSAcK Entry

id C00004266
Name Cinaroside / Luteolin 7-glucoside / Luteolin-7-O-glucoside / Luteolin 7-O-beta-D-glucopyranoside
CAS RN 5373-11-5
Standard InChI InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16?,18-,19+,20?,21-/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 2

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL233929 CHEMBL574683 CHEMBL1159535 CHEMBL1317166

KEGG

By LinkDB C03951

CTD

By CAS RN C066408

Species

Summary

Plant class

class name count
asterids 23
rosids 7
Embryophyta 4
Liliopsida 3
eudicotyledons 1

Family (Top 10)

family name count
Asteraceae 9
Gentianaceae 6
Fabaceae 4
Lamiaceae 4
Plantaginaceae 2
Frullaniaceae 2
Caprifoliaceae 2
Betulaceae 1
Conocephalaceae 1
Malvaceae 1

List (39)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia caven 72367 Fabaceae rosids Viridiplantae
Acacia furcatispina 370701 Fabaceae rosids Viridiplantae
Achyrocline satureioides 746493 Asteraceae asterids Viridiplantae
Aechmea glomerata 326767 Bromeliaceae Liliopsida Viridiplantae
Ammothamnus lehmanni Bge. 449079 Fabaceae rosids Viridiplantae
Asphodeline globifera 49695 Xanthorrhoeaceae Liliopsida Viridiplantae
Betula nigra 3508 Betulaceae rosids Viridiplantae
Clerodendron serratum 13432 Lamiaceae asterids Viridiplantae
Conocephalum conicum 41839 Conocephalaceae Embryophyta Viridiplantae
Echinop ritro
Frullania dilatata 106129 Frullaniaceae Embryophyta Viridiplantae
Frullania tamarisci 95764 Frullaniaceae Embryophyta Viridiplantae
Gentiana argentea 21496 Gentianaceae asterids Viridiplantae
Gentiana depressa 50762 Gentianaceae asterids Viridiplantae
Gentiana elwesii 21496 Gentianaceae asterids Viridiplantae
Gentiana pedicellata 21496 Gentianaceae asterids Viridiplantae
Gentiana prolata 21496 Gentianaceae asterids Viridiplantae
Gentiana sikkimensis 21496 Gentianaceae asterids Viridiplantae
Gnaphalium affine 318063 Asteraceae asterids Viridiplantae
Gutierrezia wrightii 71047 Asteraceae asterids Viridiplantae
Helichrysum graveolen 59430 Asteraceae asterids Viridiplantae
Hymenaea palustris Ducke 20675 Fabaceae rosids Viridiplantae
Lactuca indica 75953 Asteraceae asterids Viridiplantae
Melandrium album 52853 Caryophyllaceae eudicotyledons Viridiplantae
Mentha aquatica L. 190902 Lamiaceae asterids Viridiplantae
Mentha piperitae 21819 Lamiaceae asterids Viridiplantae
Onopordum acanthium 92915 Asteraceae asterids Viridiplantae
Riccia fluitans L 41843 Ricciaceae Embryophyta Viridiplantae
Santolina chamaecyperissus 41642 Asteraceae asterids Viridiplantae
Scutellaria oreophila 4139 Lamiaceae asterids Viridiplantae
Spiraea hypericifolia 409512 Rosaceae rosids Viridiplantae
Tessaria dodoneifolia 313941 Asteraceae asterids Viridiplantae
Thelesperma megapotamicum 153168 Asteraceae asterids Viridiplantae
Theobroma cacao L. 3640 Malvaceae rosids Viridiplantae
Valeriana chionophila 19952 Caprifoliaceae asterids Viridiplantae
Valeriana fedtschenkoi 19952 Caprifoliaceae asterids Viridiplantae
Veronica peregrina L. 165341 Plantaginaceae asterids Viridiplantae
Veronica spicata 165318 Plantaginaceae asterids Viridiplantae
Wurmbea dioica F.Muell. 217519 Colchicaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

26 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL233929 CHEMBL1738132 (1)
7 / 44
Q99700 Ataxin-2 Unclassified protein CHEMBL233929 CHEMBL2114784 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL233929 CHEMBL1794585 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1159535 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL233929 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL233929 CHEMBL2114780 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL233929 CHEMBL2114807 (1)
4 / 2
Q9Y253 DNA polymerase eta Enzyme CHEMBL233929 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL233929 CHEMBL1614280 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL1159535 CHEMBL1963893 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL1159535 CHEMBL814347 (1)
4 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1317166 CHEMBL1614227 (1)
3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL233929 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL233929 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL233929 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL233929 CHEMBL1159535 CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1159535 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL233929 CHEMBL1159535 CHEMBL1794536 (3)
0 / 0
P24298 Alanine aminotransferase 1 Enzyme CHEMBL233929 CHEMBL1020961 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1159535 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1159535 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL233929 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL233929 CHEMBL1964002 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL1159535 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1159535 CHEMBL1614531 (1)
1 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL233929 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc Q14191
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (53)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)