| Organism name | Acacia caven | 
|---|---|
| Genus | Acacia | 
| Family | Fabaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Acacia caven | 
|---|---|
| Linked NCBI taxonomy ID | 72367 | 
| Linked level | species | 
| Family in NCBI taxonomy | Fabaceae | 
|---|---|
| ID | 3803 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00005374   | Quercetin | CHEMBL82242 CHEMBL479232 CHEMBL1437696 | C012526 | 14 / 2 / 2 | 2 / 1 | No. 2 | No. 15 |   | 
| C00005373   | Hirsutrin / Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside | CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 | 38 / 43 / 34 | No. 2 | No. 15 |   | ||
| C00004266   | Cinaroside / Luteolin 7-glucoside / Luteolin-7-O-glucoside / Luteolin 7-O-beta-D-glucopyranoside | CHEMBL233929 CHEMBL574683 CHEMBL1159535 CHEMBL1317166 | C066408 | 26 / 31 / 53 | No. 2 | No. 15 |   | |
| C00004635   | Isorhamnetin / 3'-O-Methylquercetin / 3,4',5,7-Tetrahydroxy-3'-methoxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one | CHEMBL379064 | C047368 | 12 / 10 / 13 | 10 / 0 | No. 3 | No. 15 |   | 
| C00001059   | Isovitexin / Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | CHEMBL465360 CHEMBL1601394 | C049772 | 28 / 20 / 19 | No. 22 | No. 15 |   | |
| C00000674   | Luteolin | CHEMBL151 | D047311 | 99 / 91 / 95 | 76 / 6 | No. 71 | No. 15 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P39748 | Flap endonuclease 1 | Enzyme | C00000674 C00001059 C00004266 C00004635 C00005373 C00005374 | 0 / 0 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000674 C00001059 C00004266 C00004635 C00005373 C00005374 | 0 / 0 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000674 C00001059 C00004266 C00004635 C00005373 C00005374 | 0 / 0 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00000674 C00001059 C00004266 C00005373 C00005374 | 1 / 1 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000674 C00001059 C00004266 C00005373 C00005374 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000674 C00001059 C00004266 C00005373 C00005374 | 0 / 0 | 
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000674 C00004635 C00005373 C00005374 | 1 / 1 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000674 C00001059 C00005373 C00005374 | 0 / 0 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000674 C00001059 C00004266 C00005374 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000674 C00001059 C00004266 C00005374 | 0 / 0 | 
| O00255 | Menin | Unclassified protein | C00000674 C00001059 C00004266 C00004635 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000674 C00001059 C00004266 C00004635 | 1 / 2 | 
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000674 C00001059 C00005373 | 1 / 1 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000674 C00001059 C00005373 | 1 / 0 | 
| P06746 | DNA polymerase beta | Enzyme | C00000674 C00001059 C00005373 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000674 C00001059 C00004266 | 0 / 0 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000674 C00001059 C00004266 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000674 C00001059 C00004266 | 1 / 1 | 
| P14679 | Tyrosinase | Oxidoreductase | C00000674 C00004266 C00005373 | 4 / 2 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000674 C00001059 C00005373 | 0 / 1 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000674 C00001059 C00005373 | 1 / 4 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000674 C00001059 C00004266 | 0 / 0 | 
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001059 C00004266 C00005374 | 0 / 0 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000674 C00001059 C00005373 | 0 / 0 | 
| O75496 | Geminin | Unclassified protein | C00000674 C00004266 C00005373 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000674 C00004266 C00005373 | 4 / 3 | 
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000674 C00001059 C00004266 | 2 / 1 | 
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000674 C00004635 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000674 C00005373 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00000674 C00005373 | 11 / 10 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001059 C00004266 | 1 / 0 | 
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000674 C00005373 | 2 / 0 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000674 C00004266 | 3 / 3 | 
| P07237 | Protein disulfide-isomerase | Enzyme | C00005373 C00005374 | 0 / 0 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000674 C00004635 | 0 / 0 | 
| P04745 | Alpha-amylase 1 | Enzyme | C00000674 C00004635 | 0 / 0 | 
| P06280 | Alpha-galactosidase A | Enzyme | C00000674 C00005373 | 1 / 1 | 
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000674 C00004635 | 4 / 4 | 
| P04062 | Glucosylceramidase | Enzyme | C00000674 C00005373 | 6 / 4 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000674 C00005373 | 0 / 3 | 
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000674 C00004266 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00000674 C00004266 | 1 / 1 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000674 C00005373 | 4 / 1 | 
| P15121 | Aldose reductase | Enzyme | C00005373 C00005374 | 0 / 0 | 
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000674 C00004266 | 4 / 2 | 
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00000674 C00005373 | 0 / 0 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000674 C00004266 | 7 / 37 | 
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000674 C00005373 | 1 / 1 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000674 C00001059 | 0 / 0 | 
| Q15046 | Lysine--tRNA ligase | Enzyme | C00000674 | 2 / 1 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000674 | 2 / 0 | 
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001059 | 2 / 2 | 
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000674 | 0 / 0 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 | 
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000674 | 0 / 0 | 
| P09874 | Poly [ADP-ribose] polymerase 1 | Enzyme | C00000674 | 0 / 0 | 
| P03956 | Interstitial collagenase | M10A | C00000674 | 0 / 1 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001059 | 7 / 3 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 | 
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005373 | 0 / 0 | 
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005373 | 3 / 1 | 
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000674 | 0 / 0 | 
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000674 | 0 / 0 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000674 | 0 / 0 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00000674 | 0 / 1 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00000674 | 0 / 0 | 
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00000674 | 0 / 0 | 
| P06276 | Cholinesterase | Hydrolase | C00000674 | 0 / 0 | 
| P51570 | Galactokinase | Enzyme | C00000674 | 1 / 1 | 
| P54132 | Bloom syndrome protein | Enzyme | C00000674 | 1 / 2 | 
| P45452 | Collagenase 3 | M10A | C00000674 | 1 / 1 | 
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000674 | 2 / 0 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00005373 | 0 / 0 | 
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005373 | 0 / 1 | 
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004635 | 2 / 1 | 
| P08253 | 72 kDa type IV collagenase | M10A | C00000674 | 1 / 3 | 
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | C00000674 | 0 / 0 | 
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00000674 | 0 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000674 | 2 / 2 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000674 | 0 / 1 | 
| Q9H2K2 | Tankyrase-2 | Enzyme | C00000674 | 0 / 0 | 
| O14763 | Tumor necrosis factor receptor superfamily member 10B | Unclassified protein | C00000674 | 1 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00000674 | 1 / 1 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00000674 | 1 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 | 
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000674 | 0 / 0 | 
| P30989 | Neurotensin receptor type 1 | Neurotensin receptor | C00001059 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000674 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000674 | 0 / 1 | 
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000674 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000674 | 0 / 0 | 
| P49327 | Fatty acid synthase | Transferase | C00000674 | 0 / 0 | 
| P08183 | Multidrug resistance protein 1 | drug | C00000674 | 1 / 0 | 
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00000674 | 0 / 0 | 
| Q00534 | Cyclin-dependent kinase 6 | CMGC serine/threonine protein kinase family | C00000674 | 1 / 0 | 
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005373 | 1 / 0 | 
| P10275 | Androgen receptor | NR3C4 | C00000674 | 3 / 4 | 
| P06239 | Tyrosine-protein kinase Lck | Src | C00000674 | 0 / 1 | 
| Q04760 | Lactoylglutathione lyase | Enzyme | C00000674 | 0 / 0 | 
| P08254 | Stromelysin-1 | M10A | C00000674 | 1 / 0 | 
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005373 | 1 / 1 | 
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005373 | 0 / 0 | 
| P24298 | Alanine aminotransferase 1 | Enzyme | C00004266 | 0 / 0 | 
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000674 | 1 / 1 | 
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000674 | 3 / 1 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000674 | 3 / 2 | 
| O95271 | Tankyrase-1 | Enzyme | C00000674 | 0 / 0 | 
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000674 | 0 / 1 | 
| P14780 | Matrix metalloproteinase-9 | M10A | C00000674 | 2 / 2 | 
| P39900 | Macrophage metalloelastase | M10A | C00000674 | 0 / 0 | 
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00000674 | 0 / 0 | 
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00004635 | 0 / 0 | 
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00000674 | 0 / 0 | 
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00000674 | 0 / 0 | 
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | C00000674 | 0 / 0 | 
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00000674 | 0 / 0 | 
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005374 | 0 / 0 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000674 | 1 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00000674
                          C00004635
                          C00005374 | 
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | C00000674
                          C00004635
                          C00005374 | 
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | C00000674
                          C00004635 | 
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) | C00000674
                          C00004635 | 
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor | C00000674
                          C00004635 | 
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 | C00000674
                          C00004635 | 
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | C00000674 | 
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | C00004635 | 
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 | C00004635 | 
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 | C00004635 | 
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 | C00000674 | 
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor | C00000674 | 
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | C00000674 | 
| 581 | BAX, BCL2L4 | BCL2-associated X protein | C00000674 | 
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 | C00000674 | 
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 | C00000674 | 
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 | C00000674 | 
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | C00000674 | 
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | C00000674 | 
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | C00000674 | 
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | C00000674 | 
| 847 | CAT | catalase (EC:1.11.1.6) | C00000674 | 
| 890 | CCNA2, CCN1, CCNA | cyclin A2 | C00000674 | 
| 891 | CCNB1, CCNB | cyclin B1 | C00000674 | 
| 958 | CD40, Bp50, CDW40, TNFRSF5, p50 | CD40 molecule, TNF receptor superfamily member 5 | C00000674 | 
| 972 | CD74, DHLAG, HLADG, II, Ia-GAMMA | CD74 molecule, major histocompatibility complex, class II invariant chain | C00000674 | 
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | C00000674 | 
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) | C00000674 | 
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | C00000674 | 
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | C00000674 | 
| 1031 | CDKN2C, INK4C, p18, p18-INK4C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | C00000674 | 
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) | C00000674 | 
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | C00000674 | 
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) | C00000674 | 
| 1950 | EGF, HOMG4, URG | epidermal growth factor | C00000674 | 
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) | C00000674 | 
| 1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 | C00000674 | 
| 2203 | FBP1, FBP | fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) | C00000674 | 
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog | C00000674 | 
| 2354 | FOSB, AP-1, G0S3, GOS3, GOSB | FBJ murine osteosarcoma viral oncogene homolog B | C00000674 | 
| 4616 | GADD45B, GADD45BETA, MYD118 | growth arrest and DNA-damage-inducible, beta | C00000674 | 
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 | C00000674 | 
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta | C00000674 | 
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 | C00000674 | 
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene | C00000674 | 
| 3726 | JUNB, AP-1 | jun B proto-oncogene | C00000674 | 
| 3727 | JUND, AP-1 | jun D proto-oncogene | C00000674 | 
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) | C00000674 | 
| 5602 | MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK | mitogen-activated protein kinase 10 (EC:2.7.11.24) | C00000674 | 
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) | C00000674 | 
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) | C00000674 | 
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) | C00000674 | 
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | C00000674 | 
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | C00000674 | 
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | C00000674 | 
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | C00000674 | 
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | C00000674 | 
| 9572 | NR1D1, EAR1, THRA1, THRAL, ear-1, hRev | nuclear receptor subfamily 1, group D, member 1 | C00000674 | 
| 5347 | PLK1, PLK, STPK13 | polo-like kinase 1 (EC:2.7.11.21) | C00000674 | 
| 8000 | PSCA, PRO232 | prostate stem cell antigen | C00000674 | 
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | C00004635 | 
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) | C00000674 | 
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A | C00000674 | 
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E | C00000674 | 
| 2810 | SFN, YWHAS | stratifin | C00000674 | 
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) | C00000674 | 
| 29110 | TBK1, NAK, T2K | TANK-binding kinase 1 (EC:2.7.11.1) | C00000674 | 
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor | C00000674 | 
| 7128 | TNFAIP3, A20, OTUD7C, TNFA1P2 | tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) | C00000674 | 
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 | C00000674 | 
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 | C00000674 | 
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 | C00000674 | 
| 7161 | TP73, P73 | tumor protein p73 | C00000674 | 
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | C00000674 | 
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | C00000674 | 
| 10451 | VAV3 | vav 3 guanine nucleotide exchange factor | C00000674 | 
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 | C00000674 | 
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A | C00000674 | 
| 8839 | WISP2, CCN5, CT58, CTGF-L | WNT1 inducible signaling pathway protein 2 | C00000674 | 
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis | C00000674 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | P63092 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #103470 | Albinism, ocular, with sensorineural deafness | P14679 | 
| #203100 | Albinism, oculocutaneous, type ia; oca1a | P14679 | 
| #606952 | Albinism, oculocutaneous, type ib; oca1b | P14679 | 
| #300068 | Androgen insensitivity syndrome; ais | P10275 | 
| #312300 | Androgen insensitivity, partial; pais | P10275 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #614490 | Blood group, junior system; jr | Q9UNQ0 | 
| #210900 | Bloom syndrome; blm | P54132 | 
| #114480 | Breast cancer | P38398 | 
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 | P38398 | 
| #300615 | Brunner syndrome | P21397 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f | P04792 | 
| #613641 | Charcot-marie-tooth disease, recessive intermediate b; cmtrib | Q15046 | 
| #114500 | Colorectal cancer; crc | P18054 P84022 Q14191 | 
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b | P34949 | 
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 | P08254 | 
| #613916 | Deafness, autosomal recessive 89; dfnb89 | Q15046 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #133239 | Esophageal cancer | P04637 P18054 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #301500 | Fabry disease | P06280 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #230200 | Galactokinase deficiency | P51570 | 
| #608013 | Gaucher disease, perinatal lethal | P04062 | 
| #230800 | Gaucher disease, type i | P04062 | 
| #230900 | Gaucher disease, type ii | P04062 | 
| #231000 | Gaucher disease, type iii | P04062 | 
| #231005 | Gaucher disease, type iiic | P04062 | 
| #137750 | Glaucoma 1, open angle, a; glc1a | Q16678 | 
| #231300 | Glaucoma 3, primary congenital, a; glc3a | Q16678 | 
| #137760 | Glaucoma, primary open angle; poag | Q16678 | 
| #137800 | Glioma susceptibility 1; glm1 | O75874 | 
| #232300 | Glycogen storage disease ii | P10253 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #146300 | Hypophosphatasia, adult | P05186 | 
| #241510 | Hypophosphatasia, childhood | P05186 | 
| #241500 | Hypophosphatasia, infantile | P05186 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #612244 | Inflammatory bowel disease 13; ibd13 | P08183 | 
| #603932 | Intervertebral disc disease; idd | P14780 | 
| #601626 | Leukemia, acute myeloid; aml | P36888 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #211980 | Lung cancer | P04637 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #174800 | Mccune-albright syndrome; mas | P63092 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #613073 | Metaphyseal anadysplasia 2; mandp2 | P14780 | 
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona | P08253 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b | P04792 | 
| #257200 | Niemann-pick disease, type a | P17405 | 
| #607616 | Niemann-pick disease, type b | P17405 | 
| #166350 | Osseous heteroplasia, progressive; poh | P63092 | 
| #167000 | Ovarian cancer | P38398 | 
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 | P38398 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #168600 | Parkinson disease, late-onset; pd | P04062 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #614674 | Periodic fever, menstrual cycle-dependent | P08908 | 
| #604229 | Peters anomaly | Q16678 | 
| #172700 | Pick disease of brain | P10636 | 
| #102200 | Pituitary adenoma, growth hormone-secreting | P63092 | 
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | Q01196 | 
| #103580 | Pseudohypoparathyroidism, type ia; php1a | P63092 | 
| #603233 | Pseudohypoparathyroidism, type ib; php1b | P63092 | 
| #612462 | Pseudohypoparathyroidism, type ic; php1c | P63092 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | P14679 | 
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 | P10275 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type | P45452 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | O14763 P04637 | 
| %612223 | Stature quantitative trait locus 11; stqtl11 | Q00534 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth | P10828 | 
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth | P10828 | 
| #145650 | Thyroid hormone resistance, selective pituitary; prth | P10828 | 
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 | Q9UNQ0 | 
| #277700 | Werner syndrome; wrn | Q14191 | 
| #278300 | Xanthinuria, type i | P47989 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| #112100 | Yt blood group antigen | P22303 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) Q15046 (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00026 | Endometrial Cancer | P03372
                            (marker) P04637 (related) | 
| H00028 | Choriocarcinoma | P03956
                            (related) P04637 (related) P08253 (related) | 
| H00066 | Lewy body dementia (LBD) | P04062
                            (related) | 
| H00126 | Gaucher disease | P04062
                            (related) | 
| H00426 | Defects in the degradation of ganglioside | P04062
                            (related) | 
| H00810 | Progressive myoclonic epilepsy (PME) | P04062
                            (related) | 
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | P04150
                            (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) Q01196 (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) P28907 (marker) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00016 | Oral cancer | P04637
                            (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P04637
                            (related) P04637 (marker) P35354 (related) | 
| H00018 | Gastric cancer | P04637
                            (related) | 
| H00019 | Pancreatic cancer | P04637
                            (related) P04637 (marker) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) | 
| H00022 | Bladder cancer | P04637
                            (related) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) P08253 (related) P14780 (related) P35354 (related) | 
| H00027 | Ovarian cancer | P04637
                            (related) P38398 (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00031 | Breast cancer | P04637
                            (related) P38398 (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) P14679 (marker) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00042 | Glioma | P04637
                            (related) P04637 (marker) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00046 | Cholangiocarcinoma | P04637
                            (related) P35354 (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00055 | Laryngeal cancer | P04637
                            (related) P04637 (marker) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00856 | Distal hereditary motor neuropathies (dHMN) | P04792
                            (related) | 
| H00213 | Hypophosphatasia | P05186
                            (related) | 
| H00093 | Combined immunodeficiencies (CIDs) | P06239
                            (related) | 
| H00125 | Fabry disease | P06280
                            (related) | 
| H00472 | Torg-Winchester syndrome | P08253
                            (related) | 
| H00069 | Glycogen storage diseases (GSD) | P10253
                            (related) | 
| H00024 | Prostate cancer | P10275
                            (related) | 
| H00062 | Spinal and bulbar muscular atrophy (SBMA) | P10275
                            (related) | 
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) | P10275
                            (related) | 
| H00609 | 46,XY disorders of sex development (Other) | P10275
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00023 | Testicular cancer | P10696
                            (marker) | 
| H00249 | Thyroid hormone resistance syndrome | P10828
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00168 | Oculocutaneous albinism (OCA) | P14679
                            (related) | 
| H00479 | Metaphyseal dysplasias | P14780
                            (related) P45452 (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P16473
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H00137 | Niemann-Pick disease (NPD) typeA and B | P17405
                            (related) | 
| H00424 | Defects in the degradation of sphingomyelin | P17405
                            (related) | 
| H00548 | Brunner syndrome | P21397
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00118 | Congenital disorders of glycosylation (CDG) type I | P34949
                            (related) | 
| H00003 | Acute myeloid leukemia (AML) | P36888
                            (related) Q01196 (related) Q01196 (marker) Q13951 (marker) | 
| H00192 | Xanthinuria | P47989
                            (related) | 
| H00070 | Galactosemia | P51570
                            (related) | 
| H00094 | DNA repair defects | P54132
                            (related) | 
| H00296 | Defects in RecQ helicases | P54132
                            (related) Q14191 (related) | 
| H00244 | Pseudohypoparathyroidism | P63092
                            (related) | 
| H00441 | Progressive osseous heteroplasia (POH) | P63092
                            (related) | 
| H00501 | Fibrous dysplasia, polyostotic | P63092
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q01196
                            (related) Q01196 (marker) Q03164 (related) Q03164 (marker) | 
| H00978 | Thrombocytopenia (THC) | Q01196
                            (related) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00612 | Primary open angle glaucoma | Q16678
                            (related) | 
| H01075 | Peters anomaly | Q16678
                            (related) | 
| H01159 | Anterior segment dysgenesis (ASD) | Q16678
                            (related) | 
| H01203 | Primary congenital glaucoma (PCG) | Q16678
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) Q9NUW8 (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) |