Species

KNApSAcK Entry

Organism name Gentiana argentea
Genus Gentiana
Family Gentianaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Gentiana
Linked NCBI taxonomy ID 21496
Linked level genus

Family

Family in NCBI taxonomy Gentianaceae
ID 21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004266 External link 512 Cinaroside
/ Luteolin 7-glucoside
/ Luteolin-7-O-glucoside
/ Luteolin 7-O-beta-D-glucopyranoside
CHEMBL233929
CHEMBL574683
CHEMBL1159535
CHEMBL1317166
C066408
26 / 31 / 53 No. 2 No. 15
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00006151 External link 512 Isopyrenin
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
No. 22 No. 15

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 C00004266 2 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001059 C00004266 1 / 2
O00255 Menin Unclassified protein C00001059 C00004266 2 / 5
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 C00004266 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 C00004266 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 C00004266 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 C00004266 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001059 C00004266 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001059 C00004266 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001059 C00004266 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001059 C00004266 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 C00004266 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001059 C00004266 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001059 C00004266 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 C00004266 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001059 C00004266 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 C00004266 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004266 3 / 3
P14679 Tyrosinase Oxidoreductase C00004266 4 / 2
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00004266 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
P38398 Breast cancer type 1 susceptibility protein Enzyme C00004266 4 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00004266 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 0 / 0
O75496 Geminin Unclassified protein C00004266 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00004266 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001059 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 1 / 1
P06746 DNA polymerase beta Enzyme C00001059 0 / 0
Q99700 Ataxin-2 Unclassified protein C00004266 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001059 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00004266 7 / 37

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc Q14191
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (61)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)