Species

KNApSAcK Entry

Organism name Hymenaea palustris Ducke
Genus Hymenaea
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hymenaea
Linked NCBI taxonomy ID 20675
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004266 External link 512 Cinaroside
/ Luteolin 7-glucoside
/ Luteolin-7-O-glucoside
/ Luteolin 7-O-beta-D-glucopyranoside
CHEMBL233929
CHEMBL574683
CHEMBL1159535
CHEMBL1317166
C066408
26 / 31 / 53 No. 2 No. 15
C00001029 External link 512 Chrysoeriol
/ Luteolin 3'-methyl ether
CHEMBL214321
C007054
20 / 24 / 20 8 / 0 No. 3 No. 15
C00013329 External link 512 Tricin
/ 5,7,4'-Trihydroxy-3',5'-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL454320
C017769
No. 3 No. 15
C00044464 External link 512 5'-Methoxyhydnocarpin D
CHEMBL328060
No. 338

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001029 C00004266 0 / 0
O00255 Menin Unclassified protein C00001029 C00004266 2 / 5
P10636 Microtubule-associated protein tau Unclassified protein C00001029 C00004266 4 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001029 C00004266 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001029 C00004266 1 / 2
P38398 Breast cancer type 1 susceptibility protein Enzyme C00001029 C00004266 4 / 2
O75496 Geminin Unclassified protein C00001029 C00004266 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001029 C00004266 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001029 C00004266 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001029 5 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001029 2 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001029 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00001029 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004266 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00004266 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001029 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00004266 0 / 0
P14679 Tyrosinase Oxidoreductase C00004266 4 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001029 1 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001029 4 / 4
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001029 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004266 3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001029 1 / 1
P06746 DNA polymerase beta Enzyme C00001029 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00004266 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00004266 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004266 0 / 0
Q99700 Ataxin-2 Unclassified protein C00004266 1 / 1
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001029 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004266 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00004266 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004266 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00004266 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00004266 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00004266 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00004266 7 / 37
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00004266 2 / 1

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001029
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001029
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001029
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001029
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001029
4543 MTNR1A, MEL-1A-R, MT1 melatonin receptor 1A C00001029
4544 MTNR1B, FGQTL2, MEL-1B-R, MT2 melatonin receptor 1B C00001029
4835 NQO2, DHQV, DIA6, NMOR2, QR2 NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) C00001029

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (42)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
Q14191
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)