Species

KNApSAcK Entry

Organism name Salvia mirzayana
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia
Linked NCBI taxonomy ID 21880
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001029 External link 512 Chrysoeriol
/ Luteolin 3'-methyl ether
CHEMBL214321
C007054
20 / 24 / 20 8 / 0 No. 3 No. 15
C00003837 External link 512 Cirsimaritin
CHEMBL348436
C007072
13 / 18 / 14 No. 3 No. 15
C00003894 External link 512 Eupatorin
/ 3',5-Dihydroxy-4',6,7-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL487402
C103110
5 / 5 / 4 5 / 0 No. 3 No. 15
C00003840 External link 512 Salvigenin
CHEMBL376644
C014049
No. 35 No. 15

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00001029 C00003837 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001029 C00003837 4 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001029 C00003837 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001029 C00003894 4 / 4
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001029 C00003894 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00001029 4 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001029 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001029 0 / 0
O14965 Aurora kinase A Aur C00003894 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00001029 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001029 1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003837 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001029 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001029 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001029 2 / 0
O75496 Geminin Unclassified protein C00001029 0 / 0
P04062 Glucosylceramidase Enzyme C00003837 6 / 4
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003837 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003837 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00003837 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001029 1 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001029 5 / 3
P33765 Adenosine receptor A3 Adenosine receptor C00003837 0 / 0
Q96GD4 Aurora kinase B Aur C00003894 0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00003894 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001029 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001029 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003837 0 / 3
Q9UNA4 DNA polymerase iota Enzyme C00003837 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003837 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001029 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003837 0 / 0
O00255 Menin Unclassified protein C00001029 2 / 5

11 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001029 C00003894
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001029 C00003894
4543 MTNR1A, MEL-1A-R, MT1 melatonin receptor 1A C00001029
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001029
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001029
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001029
4544 MTNR1B, FGQTL2, MEL-1B-R, MT2 melatonin receptor 1B C00001029
4835 NQO2, DHQV, DIA6, NMOR2, QR2 NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) C00001029
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003894
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00003894
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003894

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#237500 Dubin-johnson syndrome; djs Q92887
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#602089 Hemangioma, capillary infantile P35968
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (31)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)