Cannabis sativa L.
Species
KNApSAcK Entry
| Organism name | Cannabis sativa L. |
|---|---|
| Genus | Cannabis |
| Family | Cannabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cannabis sativa |
|---|---|
| Linked NCBI taxonomy ID | 3483 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cannabaceae |
|---|---|
| ID | 3481 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (63)
| Species | Activity |
|---|---|
| Cannabis sativa L. | Abortifacient |
| Cannabis sativa L. | Aldose-Reductase Inhibitor |
| Cannabis sativa L. | Alterative |
| Cannabis sativa L. | AMP Inhbitor |
| Cannabis sativa L. | Analgesic |
| Cannabis sativa L. | Anaphrodisiac |
| Cannabis sativa L. | Anesthetic |
| Cannabis sativa L. | Anti-MS |
| Cannabis sativa L. | Antiasthmatic |
| Cannabis sativa L. | Antibacterial |
| Cannabis sativa L. | Anticonvulsant |
| Cannabis sativa L. | Antidote |
| Cannabis sativa L. | Antidote, strychnine |
| Cannabis sativa L. | Antiemetic |
| Cannabis sativa L. | Antiglaucomic |
| Cannabis sativa L. | Antiinflammatory |
| Cannabis sativa L. | Antipyretic |
| Cannabis sativa L. | Antiseptic |
| Cannabis sativa L. | Antiserotonin |
| Cannabis sativa L. | Antispasmodic |
| Cannabis sativa L. | Antitumor |
| Cannabis sativa L. | Antitussive |
| Cannabis sativa L. | Antiviral |
| Cannabis sativa L. | Anxiogenic |
| Cannabis sativa L. | Aperitif |
| Cannabis sativa L. | Aphrodisiac |
| Cannabis sativa L. | Astringent |
| Cannabis sativa L. | Bronchodilator |
| Cannabis sativa L. | Cardiotonic |
| Cannabis sativa L. | Cataleptic |
| Cannabis sativa L. | Cholagogue |
| Cannabis sativa L. | CNS Stimulant |
| Cannabis sativa L. | Convulsant |
| Cannabis sativa L. | Demulcent |
| Cannabis sativa L. | Diuretic |
| Cannabis sativa L. | Emmenagogue |
| Cannabis sativa L. | Emollient |
| Cannabis sativa L. | Estrogenic |
| Cannabis sativa L. | Euphoriant |
| Cannabis sativa L. | Exhilarent |
| Cannabis sativa L. | Hallucinogen |
| Cannabis sativa L. | Hypertensive |
| Cannabis sativa L. | Hyperthermic |
| Cannabis sativa L. | Hypnotic |
| Cannabis sativa L. | Hypotensive |
| Cannabis sativa L. | Immunodepressant |
| Cannabis sativa L. | Inebriant |
| Cannabis sativa L. | Intoxicant |
| Cannabis sativa L. | Laxative |
| Cannabis sativa L. | Myorelaxant |
| Cannabis sativa L. | Narcotic |
| Cannabis sativa L. | Poison |
| Cannabis sativa L. | Psychotropic |
| Cannabis sativa L. | Respiradepressant |
| Cannabis sativa L. | Sedative |
| Cannabis sativa L. | Soporific |
| Cannabis sativa L. | Stimulant |
| Cannabis sativa L. | Stomachic |
| Cannabis sativa L. | Sympathomimetic |
| Cannabis sativa L. | Teratogenic |
| Cannabis sativa L. | Tonic |
| Cannabis sativa L. | Vasodilator |
| Cannabis sativa L. | Vermifuge |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001029
|
Chrysoeriol
/ Luteolin 3'-methyl ether |
CHEMBL214321
|
C007054
|
20 / 24 / 20 | 8 / 0 | No. 3 | No. 15 |
|
|
C00004089
|
6-Prenylapigenin
/ 6-C-Prenylapigenin / 5,7,4'-Trihydroxy-6-prenylflavone / 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
No. 15 | No. 15 |
|
Human Protein / Gene in interactions
20 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001029 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00001029 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001029 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001029 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00001029 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001029 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001029 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001029 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001029 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00001029 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001029 | 4 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001029 | 1 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001029 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00001029 | 4 / 4 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001029 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001029 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001029 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001029 | 4 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001029 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001029 | 2 / 5 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001029
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001029
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001029
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001029
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001029
|
| 4543 | MTNR1A, MEL-1A-R, MT1 | melatonin receptor 1A |
C00001029
|
| 4544 | MTNR1B, FGQTL2, MEL-1B-R, MT2 | melatonin receptor 1B |
C00001029
|
| 4835 | NQO2, DHQV, DIA6, NMOR2, QR2 | NAD(P)H dehydrogenase, quinone 2 (EC:1.10.99.2) |
C00001029
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (24)
| OMIM | preferred title | UniProt |
|---|---|---|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (20)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|