PCIDB

Ocimum basilicum L.

Species

KNApSAcK Entry

Organism name Ocimum basilicum L.
Genus Ocimum
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ocimum basilicum
Linked NCBI taxonomy ID 39350
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (54)

Species Activity
Ocimum basilicum L. Alexeteric
Ocimum basilicum L. Analgesic
Ocimum basilicum L. Antacid
Ocimum basilicum L. Antialzheimeran
Ocimum basilicum L. Antiarthritic
Ocimum basilicum L. Antibacterial
Ocimum basilicum L. Anticancer
Ocimum basilicum L. Anticoagulase
Ocimum basilicum L. Anticomplementary
Ocimum basilicum L. Antidote
Ocimum basilicum L. Antiinflammatory
Ocimum basilicum L. Antioxidant
Ocimum basilicum L. Antiplaque
Ocimum basilicum L. Antitumor
Ocimum basilicum L. Antiulcer
Ocimum basilicum L. Aperitif
Ocimum basilicum L. Aphrodisiac
Ocimum basilicum L. Aromatic
Ocimum basilicum L. Bradycardic
Ocimum basilicum L. Candidicide
Ocimum basilicum L. Carcinogenic
Ocimum basilicum L. Carminative
Ocimum basilicum L. COX-2-Inhibitor
Ocimum basilicum L. Cyanogenic
Ocimum basilicum L. Demulcent
Ocimum basilicum L. Deodorant
Ocimum basilicum L. Diaphoretic
Ocimum basilicum L. Digestive
Ocimum basilicum L. Diuretic
Ocimum basilicum L. Emmenagogue
Ocimum basilicum L. Enterotonic
Ocimum basilicum L. Expectorant
Ocimum basilicum L. Fullness
Ocimum basilicum L. Fungicide
Ocimum basilicum L. Gastrotonic
Ocimum basilicum L. Glutathionigenic
Ocimum basilicum L. Hemostat
Ocimum basilicum L. Hepatocarcinogenic
Ocimum basilicum L. Insecticide
Ocimum basilicum L. Insectifuge
Ocimum basilicum L. Lactagogue
Ocimum basilicum L. Larvicide
Ocimum basilicum L. Laxative
Ocimum basilicum L. Narcotic
Ocimum basilicum L. Parasiticide
Ocimum basilicum L. Pectoral
Ocimum basilicum L. Sedative
Ocimum basilicum L. Sternutator
Ocimum basilicum L. Stimulant
Ocimum basilicum L. Stomachic
Ocimum basilicum L. Tonic
Ocimum basilicum L. Tranquilizer
Ocimum basilicum L. Vermicide
Ocimum basilicum L. Vermifuge

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001075 External link 512 Nevadensin
CHEMBL312073
C023982
1 / 0 / 0 No. 3 No. 15
C00001016 External link 512 7-O-Methylacacetin
/ Acacetin 7-methyl ether
/ Genkwanin 4'-methyl ether
/ Apigenin 7,4'-dimethyl ether
/ 5-Hydroxy-4',7-dimethoxyflavone
/ 5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL350958
C044998
1 / 0 / 0 No. 3 No. 15
C00001043 External link 512 Genkwanin
CHEMBL210635
C014568
5 / 4 / 5 3 / 0 No. 3 No. 15
C00003820 External link 512 Acacetin
/ Apigenin 4'-methyl ether
/ 5,7-Dihydroxy-4'-methoxyflavone
CHEMBL243664
C023717
37 / 55 / 72 5 / 0 No. 3 No. 15
C00003883 External link 512 Gardenin B
/ Demethyltangeretin
/ 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL226512
7 / 10 / 4 No. 8 No. 15
C00003840 External link 512 Salvigenin
CHEMBL376644
C014049
No. 35 No. 15
C00000674 External link 512 Luteolin
CHEMBL151
D047311
99 / 91 / 95 76 / 6 No. 71 No. 15

Human Protein / Gene in interactions

113 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00000674 C00003820 C00003883 1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000674 C00001043 C00003820 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000674 C00001043 C00003820 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000674 C00003820 C00003883 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000674 C00003820 C00003883 2 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000674 C00001043 C00003820 4 / 4
P04745 Alpha-amylase 1 Enzyme C00000674 C00001043 C00003820 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000674 C00003820 0 / 0
P10275 Androgen receptor NR3C4 C00000674 C00003820 3 / 4
P10636 Microtubule-associated protein tau Unclassified protein C00000674 C00003820 4 / 3
Q9UNA4 DNA polymerase iota Enzyme C00000674 C00003820 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000674 C00003820 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000674 C00003820 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000674 C00003820 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000674 C00003820 2 / 0
P06239 Tyrosine-protein kinase Lck Src C00000674 C00001043 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00003820 C00003883 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000674 C00003820 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000674 C00003820 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00000674 C00003820 0 / 1
P02545 Prelamin-A/C Unclassified protein C00000674 C00003820 11 / 10
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000674 C00003820 4 / 2
O75496 Geminin Unclassified protein C00000674 C00003883 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000674 C00003820 4 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000674 C00003820 0 / 0
O00255 Menin Unclassified protein C00000674 C00003820 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000674 C00003820 1 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00000674 C00003820 7 / 37
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00001075 C00003883 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000674 C00003820 0 / 1
Q9Y253 DNA polymerase eta Enzyme C00000674 1 / 1
P49327 Fatty acid synthase Transferase C00000674 0 / 0
P08183 Multidrug resistance protein 1 drug C00000674 1 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00000674 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00000674 0 / 0
P54132 Bloom syndrome protein Enzyme C00000674 1 / 2
P51570 Galactokinase Enzyme C00000674 1 / 1
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00000674 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00000674 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00003820 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00000674 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000674 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000674 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00000674 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000674 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00000674 1 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000674 1 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000674 1 / 1
P39748 Flap endonuclease 1 Enzyme C00000674 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000674 3 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000674 1 / 1
P51151 Ras-related protein Rab-9A Unclassified protein C00003820 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000674 3 / 2
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00000674 0 / 0
P03956 Interstitial collagenase M10A C00000674 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003883 7 / 3
P24941 Cyclin-dependent kinase 2 Cdc2 C00000674 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000674 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000674 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003820 0 / 0
P14679 Tyrosinase Oxidoreductase C00000674 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00003820 5 / 3
O95271 Tankyrase-1 Enzyme C00000674 0 / 0
P06276 Cholinesterase Hydrolase C00000674 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000674 1 / 1
P28907 ADP-ribosyl cyclase 1 Enzyme C00000674 0 / 1
P45452 Collagenase 3 M10A C00000674 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000674 2 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00003820 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000674 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000674 2 / 2
P08253 72 kDa type IV collagenase M10A C00000674 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000674 3 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00003820 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000674 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00003820 1 / 1
P39900 Macrophage metalloelastase M10A C00000674 0 / 0
Q9H2K2 Tankyrase-2 Enzyme C00000674 0 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00000674 1 / 0
P03372 Estrogen receptor NR3A1 C00000674 1 / 1
P22303 Acetylcholinesterase Hydrolase C00000674 1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000674 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000674 1 / 1
P04062 Glucosylceramidase Enzyme C00000674 6 / 4
P06746 DNA polymerase beta Enzyme C00000674 0 / 0
Q15046 Lysine--tRNA ligase Enzyme C00000674 2 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00000674 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000674 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001016 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000674 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000674 0 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003820 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00000674 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00000674 0 / 0
P08254 Stromelysin-1 M10A C00000674 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000674 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000674 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000674 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000674 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000674 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00000674 0 / 0
P49336 Cyclin-dependent kinase 8 Cdk8 C00003820 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00000674 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000674 1 / 4
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00000674 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00000674 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00000674 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00000674 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00000674 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00000674 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000674 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000674 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003820 1 / 1

78 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000674 C00001043 C00003820
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000674 C00001043 C00003820
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001043 C00003820
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000674 C00003820
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000674
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000674
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000674
177 AGER, RAGE advanced glycosylation end product-specific receptor C00000674
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000674
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000674
581 BAX, BCL2L4 BCL2-associated X protein C00000674
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000674
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00000674
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00000674
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000674
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000674
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000674
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000674
847 CAT catalase (EC:1.11.1.6) C00000674
890 CCNA2, CCN1, CCNA cyclin A2 C00000674
891 CCNB1, CCNB cyclin B1 C00000674
958 CD40, Bp50, CDW40, TNFRSF5, p50 CD40 molecule, TNF receptor superfamily member 5 C00000674
972 CD74, DHLAG, HLADG, II, Ia-GAMMA CD74 molecule, major histocompatibility complex, class II invariant chain C00000674
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00000674
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000674
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000674
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000674
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00000674
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00000674
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00000674
1950 EGF, HOMG4, URG epidermal growth factor C00000674
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00000674
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00000674
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000674
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000674
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00000674
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00000674
2354 FOSB, AP-1, G0S3, GOS3, GOSB FBJ murine osteosarcoma viral oncogene homolog B C00000674
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00000674
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000674
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000674
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000674
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000674
3726 JUNB, AP-1 jun B proto-oncogene C00000674
3727 JUND, AP-1 jun D proto-oncogene C00000674
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000674
5602 MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK mitogen-activated protein kinase 10 (EC:2.7.11.24) C00000674
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000674
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000674
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00000674
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00000674
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000674
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00000674
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000674
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00000674
9572 NR1D1, EAR1, THRA1, THRAL, ear-1, hRev nuclear receptor subfamily 1, group D, member 1 C00000674
5347 PLK1, PLK, STPK13 polo-like kinase 1 (EC:2.7.11.21) C00000674
8000 PSCA, PRO232 prostate stem cell antigen C00000674
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003820
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000674
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000674
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00000674
2810 SFN, YWHAS stratifin C00000674
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000674
29110 TBK1, NAK, T2K TANK-binding kinase 1 (EC:2.7.11.1) C00000674
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000674
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00000674
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000674
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00000674
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00000674
7161 TP73, P73 tumor protein p73 C00000674
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000674
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000674
10451 VAV3 vav 3 guanine nucleotide exchange factor C00000674
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000674
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00000674
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00000674
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00000674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (105)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#230200 Galactokinase deficiency P51570
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (101)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00070 Galactosemia P51570 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009202 Cardiomyopathies C00000674
D002386 Cataract C00000674
D005483 Flushing C00000674
D006529 Hepatomegaly C00000674
D008103 Liver Cirrhosis C00000674
D010051 Ovarian Neoplasms C00000674