PCIDB

KNApSAcK Metabolite C00001043

Metabolite

KNApSAcK Entry

id C00001043
Name Genkwanin
CAS RN 437-64-9
Standard InChI InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL210635
By standard InChI Main Layer CHEMBL210635

KEGG

By LinkDB C10046

CTD

By CAS RN C014568

Species

Summary

Plant class

class name count
asterids 19
rosids 7
Euphyllophyta 2

Family

family name count
Lamiaceae 18
Fabaceae 4
Pteridaceae 2
Zygophyllaceae 2
Thymelaeaceae 1
Asteraceae 1

List (29)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia constricta 138020 Fabaceae rosids Viridiplantae
Artemisia capillaris 265783 Asteraceae asterids Viridiplantae
Cheilanthes albomarginata 238826 Pteridaceae Euphyllophyta Viridiplantae
Cheilanthes rufa 37456 Pteridaceae Euphyllophyta Viridiplantae
Daphne genkwa 66679 Thymelaeaceae rosids Viridiplantae
Glycyrrhiza glabra 49827 Fabaceae rosids Viridiplantae
Larrea divaricata 108399 Zygophyllaceae rosids Viridiplantae
Larrea tridentata 66636 Zygophyllaceae rosids Viridiplantae
Medicago polymorpha 47084 Fabaceae rosids Viridiplantae
Mimosa hostilis 21013 Fabaceae rosids Viridiplantae
Ocimum americanum L.var.pilosum (Willd.) Paton 39173 Lamiaceae asterids Viridiplantae
Ocimum basilicum L. 39350 Lamiaceae asterids Viridiplantae
Ocimum kilimandscharicum L. 39173 Lamiaceae asterids Viridiplantae
Ocimum selloi Benth. 204218 Lamiaceae asterids Viridiplantae
Ocimum x citriodorum Vis. 204098 Lamiaceae asterids Viridiplantae
Plectranthus fruticosus 306376 Lamiaceae asterids Viridiplantae
Salvia dorrii 207754 Lamiaceae asterids Viridiplantae
Salvia glutinosa 49211 Lamiaceae asterids Viridiplantae
Salvia lavandulaefolia 49214 Lamiaceae asterids Viridiplantae
Salvia lavandulifolia 49214 Lamiaceae asterids Viridiplantae
Salvia microsiphon 21880 Lamiaceae asterids Viridiplantae
Salvia nicolsoniana 21880 Lamiaceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Salvia palaestina 268920 Lamiaceae asterids Viridiplantae
Salvia sapinae 21880 Lamiaceae asterids Viridiplantae
Salvia stenophylla 202612 Lamiaceae asterids Viridiplantae
Salvia yosgadensis 21880 Lamiaceae asterids Viridiplantae
Syphopappus polystachyus
Teucrium ramosissimum 21896 Lamiaceae asterids Viridiplantae

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL210635 CHEMBL1780345 (1) CHEMBL1780385 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL210635 CHEMBL1100507 (1)
0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL210635 CHEMBL1780346 (1)
4 / 4
P04745 Alpha-amylase 1 Enzyme CHEMBL210635 CHEMBL964479 (2)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL210635 CHEMBL941407 (1)
0 / 1

CTD interaction (5)

compound gene gene name gene description interaction interaction type form reference
pmid
C014568 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of genkwanin increases metabolic processing
protein 19666078
C014568 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) genkwanin results in decreased activity of CYP1A1 protein decreases activity
protein 21482471
C014568 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased metabolism of genkwanin increases metabolic processing
protein 19666078
C014568 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased metabolism of genkwanin increases metabolic processing
protein 19666078
C014568 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin increases chemical synthesis
/ increases metabolic processing
protein 19666078

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#604229 Peters anomaly Q16678

KEGG DISEASE (5)

KEGG disease name UniProt
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)