Species

KNApSAcK Entry

Organism name Plectranthus fruticosus
Genus Plectranthus
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Plectranthus fruticosus
Linked NCBI taxonomy ID 306376
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001043 External link 512 Genkwanin
CHEMBL210635
C014568
5 / 4 / 5 3 / 0 No. 3 No. 15
C00003837 External link 512 Cirsimaritin
CHEMBL348436
C007072
13 / 18 / 14 No. 3 No. 15
C00003894 External link 512 Eupatorin
/ 3',5-Dihydroxy-4',6,7-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL487402
C103110
5 / 5 / 4 5 / 0 No. 3 No. 15
C00003840 External link 512 Salvigenin
CHEMBL376644
C014049
No. 35 No. 15

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001043 C00003894 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001043 C00003894 4 / 4
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003837 7 / 3
P06746 DNA polymerase beta Enzyme C00003837 0 / 0
P04062 Glucosylceramidase Enzyme C00003837 6 / 4
O14965 Aurora kinase A Aur C00003894 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003837 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003837 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00001043 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003837 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00003837 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003837 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003837 0 / 3
P04745 Alpha-amylase 1 Enzyme C00001043 0 / 0
Q96GD4 Aurora kinase B Aur C00003894 0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00003894 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003837 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003837 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003837 4 / 3
P06239 Tyrosine-protein kinase Lck Src C00001043 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003837 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001043 C00003894
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001043 C00003894
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003894
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001043
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00003894
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003894

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#602089 Hemangioma, capillary infantile P35968
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (19)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)