PCIDB

Hypecoum procumbens

Species

KNApSAcK Entry

Organism name Hypecoum procumbens
Genus Hypecoum
Family Fumariaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hypecoum procumbens
Linked NCBI taxonomy ID 391933
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001872 External link 512 Isocorydine
/ (+)-Isocorydine
/ L-(+)-Isocorydine
/ (S)-(+)-Isocorydine
CHEMBL489525
CHEMBL1376826
14 / 7 / 10 No. 20 No. 4
C00001824 External link 512 Bulbocapnine
/ d-Bulbocapnine
CHEMBL157912
C083807
0 / 1 No. 20 No. 4
C00027545 External link 512 Hypecorinine
No. 512 No. 4
C00001906 External link 512 Fumarin
/ Biflorine
/ Protopine
/ Fumarine
/ Corydinine
CHEMBL453019
C009093
5 / 5 / 4 2 / 0 No. 820 No. 4
C00001799 External link 512 Thalictrimine
/ Allocryptopine
/ alpha-Fagarine
/ beta-Homochelidonine
/ alpha-Allocryptopine
CHEMBL520043
C109505
3 / 2 / 3 2 / 0 No. 820 No. 4
C00027332 External link 512 Cryptopin
/ Cryptopine
/ Kryptopine
/ Kryptocavin
/ Cryptocavine
CHEMBL1339015
C007159
6 / 5 / 8 No. 820 No. 4
C00029160 External link 512 Turkiyenine
No. 3104
C00027458 External link 512 Oxyhydrastinine
/ N-Methylnoroxyhydrastinine
C048352
No. 3603

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001872 C00001906 C00027332 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001872 C00001906 C00027332 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001872 C00001906 C00027332 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001872 C00001906 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001799 C00027332 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001872 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001872 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00027332 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001872 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001872 3 / 3
P24941 Cyclin-dependent kinase 2 Cdc2 C00001872 0 / 0
O75496 Geminin Unclassified protein C00001872 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001799 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001906 3 / 2
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001872 1 / 0
O00255 Menin Unclassified protein C00027332 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001872 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001872 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001872 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001799 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001799 C00001906
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001799 C00001906

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196

KEGG DISEASE (19)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001824