Species

KNApSAcK Entry

Organism name Lindera glauca
Genus Lindera
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lindera glauca
Linked NCBI taxonomy ID 332435
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027438 External link 512 Sanjoinine Ib
/ Norisocorydine
CHEMBL465212
No. 20 No. 4
C00027304 External link 512 Boldine
/ d-Boldine
/ (+)-Boldine
CHEMBL388342
CHEMBL1321247
CHEMBL1437753
C011686
34 / 32 / 35 No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00025675 External link 512 Lauroscholtzine
/ 2-O-Methylboldine
/ N-Methyllaurotetanine
/ (+)-N-Methyllaurotetanine
CHEMBL464099
1 / 1 / 0 No. 20 No. 4
C00027405 External link 512 Laetanine
/ (+)-Laetanine
No. 20 No. 4
C00027433 External link 512 Laurolitsine
/ (+)-Norboldine
/ (+)-Laurolitsine
CHEMBL487388
C109133
No. 20 No. 4
C00001827 External link 512 Canadine
/ Xanthopuccine
/ Tetrahydroberberine
/ Tetrahydroumbellatine
CHEMBL275097
CHEMBL490533
CHEMBL476501
C004645
22 / 36 / 28 No. 37 No. 4
C00025935 External link 512 Lysicamine
/ Oxonuciferine
CHEMBL510090
C069090
No. 74
C00026002 External link 512 Pallidine
/ (-)-Pallidine
/ (-)-Isosalutaridine
No. 426 No. 4
C00027426 External link 512 N-Methylflavinantine
No. 426 No. 4
C00025334 External link 512 trans-Feruloyltyramine
/ N-trans-Feruloyltyramine
/ trans-N-Feruloyltyramine
CHEMBL206555
CHEMBL451720
1 / 4 / 2 No. 499
C00025324 External link 512 N-cis-Feruloyltyramine
/ cis-N-Feruloyltyramine
CHEMBL206555
CHEMBL451720
1 / 4 / 2 No. 499
C00000661 External link 512 N-trans-Sinapoyltyramine
CHEMBL226587
No. 499

Human Protein / Gene in interactions

50 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001827 C00001869 C00027304 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001827 C00001869 C00027304 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001827 C00001869 C00027304 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001827 C00001869 C00027304 0 / 1
O00255 Menin Unclassified protein C00001827 C00001869 C00027304 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001827 C00001869 C00027304 1 / 2
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001827 C00025675 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 C00027304 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001827 C00027304 11 / 10
Q9UBT6 DNA polymerase kappa Enzyme C00001869 C00027304 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001827 C00027304 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 C00027304 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001869 C00027304 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 C00027304 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001827 C00027304 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001869 C00027304 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 C00027304 1 / 4
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 C00027304 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 C00027304 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001827 C00027304 0 / 0
O75496 Geminin Unclassified protein C00001827 C00027304 0 / 0
P14679 Tyrosinase Oxidoreductase C00025324 C00025334 4 / 2
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00027304 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00027304 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00027304 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001827 7 / 3
P13726 Tissue factor Membrane receptor C00001827 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001827 2 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00027304 0 / 0
P39748 Flap endonuclease 1 Enzyme C00027304 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00027304 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001827 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027304 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001827 2 / 0
Q9UNA4 DNA polymerase iota Enzyme C00027304 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001827 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00027304 1 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00027304 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00027304 1 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00001827 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00027304 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00027304 0 / 0
P29466 Caspase-1 C14 C00001869 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00027304 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00001827 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
Q14654 ATP-sensitive inward rectifier potassium channel 11 K C00001827 3 / 4
Q09428 ATP-binding cassette sub-family C member 8 K C00001827 5 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#606176 Diabetes mellitus, permanent neonatal; pndm Q09428
Q14654
#610374 Diabetes mellitus, transient neonatal, 2 Q09428
#610582 Diabetes mellitus, transient neonatal, 3 Q14654
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#256450 Hyperinsulinemic hypoglycemia, familial, 1; hhf1 Q09428
#601820 Hyperinsulinemic hypoglycemia, familial, 2; hhf2 Q14654
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 Q09428
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240800 Hypoglycemia, leucine-induced; lih Q09428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (77)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) Q09428 (related)
Q14654 (related)
H00513 Transient neonatal diabetes mellitus (TNDM) Q09428 (related)
Q14654 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) Q09428 (related)
Q14654 (related)
H00409 Type II diabetes mellitus Q14654 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)