| Organism name | Lindera glauca | 
|---|---|
| Genus | Lindera | 
| Family | Lauraceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Lindera glauca | 
|---|---|
| Linked NCBI taxonomy ID | 332435 | 
| Linked level | species | 
| Family in NCBI taxonomy | Lauraceae | 
|---|---|
| ID | 3433 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | Magnoliophyta | 
|---|---|
| ID | 3398 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00027438   | Sanjoinine Ib / Norisocorydine | CHEMBL465212 | No. 20 | No. 4 |   | |||
| C00027304   | Boldine / d-Boldine / (+)-Boldine | CHEMBL388342 CHEMBL1321247 CHEMBL1437753 | C011686 | 34 / 32 / 35 | No. 20 | No. 4 |   | |
| C00001869   | Isoboldine / (S)-Isoboldine | CHEMBL462880 | 19 / 22 / 55 | No. 20 | No. 4 |   | ||
| C00025675   | Lauroscholtzine / 2-O-Methylboldine / N-Methyllaurotetanine / (+)-N-Methyllaurotetanine | CHEMBL464099 | 1 / 1 / 0 | No. 20 | No. 4 |   | ||
| C00027405   | Laetanine / (+)-Laetanine | No. 20 | No. 4 |   | ||||
| C00027433   | Laurolitsine / (+)-Norboldine / (+)-Laurolitsine | CHEMBL487388 | C109133 | No. 20 | No. 4 |   | ||
| C00001827   | Canadine / Xanthopuccine / Tetrahydroberberine / Tetrahydroumbellatine | CHEMBL275097 CHEMBL490533 CHEMBL476501 | C004645 | 22 / 36 / 28 | No. 37 | No. 4 |   | |
| C00025935   | Lysicamine / Oxonuciferine | CHEMBL510090 | C069090 | No. 74 |   | |||
| C00026002   | Pallidine / (-)-Pallidine / (-)-Isosalutaridine | No. 426 | No. 4 |   | ||||
| C00027426   | N-Methylflavinantine | No. 426 | No. 4 |   | ||||
| C00025334   | trans-Feruloyltyramine / N-trans-Feruloyltyramine / trans-N-Feruloyltyramine | CHEMBL206555 CHEMBL451720 | 1 / 4 / 2 | No. 499 |   | |||
| C00025324   | N-cis-Feruloyltyramine / cis-N-Feruloyltyramine | CHEMBL206555 CHEMBL451720 | 1 / 4 / 2 | No. 499 |   | |||
| C00000661   | N-trans-Sinapoyltyramine | CHEMBL226587 | No. 499 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001827 C00001869 C00027304 | 1 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001827 C00001869 C00027304 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001827 C00001869 C00027304 | 0 / 1 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001827 C00001869 C00027304 | 0 / 1 | 
| O00255 | Menin | Unclassified protein | C00001827 C00001869 C00027304 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001827 C00001869 C00027304 | 1 / 2 | 
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00001827 C00025675 | 1 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001869 C00027304 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00001827 C00027304 | 11 / 10 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001869 C00027304 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00001827 C00027304 | 1 / 1 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001869 C00027304 | 0 / 1 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001869 C00027304 | 4 / 3 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001869 C00027304 | 0 / 0 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001827 C00027304 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001869 C00027304 | 0 / 0 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001869 C00027304 | 1 / 4 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001869 C00027304 | 2 / 2 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001869 C00027304 | 3 / 3 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001827 C00027304 | 0 / 0 | 
| O75496 | Geminin | Unclassified protein | C00001827 C00027304 | 0 / 0 | 
| P14679 | Tyrosinase | Oxidoreductase | C00025324 C00025334 | 4 / 2 | 
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00027304 | 0 / 0 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00027304 | 1 / 1 | 
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00027304 | 0 / 0 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001827 | 7 / 3 | 
| P13726 | Tissue factor | Membrane receptor | C00001827 | 0 / 0 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001827 | 2 / 0 | 
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00027304 | 0 / 0 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00027304 | 0 / 0 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00027304 | 0 / 0 | 
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001827 | 0 / 0 | 
| P55210 | Caspase-7 | C14 | C00001869 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00027304 | 0 / 0 | 
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001827 | 2 / 0 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00027304 | 0 / 0 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001827 | 0 / 0 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00027304 | 1 / 0 | 
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00027304 | 1 / 1 | 
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00027304 | 1 / 1 | 
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001827 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00027304 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001869 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00027304 | 0 / 0 | 
| P29466 | Caspase-1 | C14 | C00001869 | 0 / 0 | 
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00027304 | 1 / 1 | 
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001827 | 0 / 0 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001869 | 7 / 37 | 
| Q14654 | ATP-sensitive inward rectifier potassium channel 11 | K | C00001827 | 3 / 4 | 
| Q09428 | ATP-binding cassette sub-family C member 8 | K | C00001827 | 5 / 3 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | P63092 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #103470 | Albinism, ocular, with sensorineural deafness | P14679 | 
| #203100 | Albinism, oculocutaneous, type ia; oca1a | P14679 | 
| #606952 | Albinism, oculocutaneous, type ib; oca1b | P14679 | 
| #103780 | Alcohol dependence | P14416 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #114500 | Colorectal cancer; crc | P84022 | 
| #606176 | Diabetes mellitus, permanent neonatal; pndm | Q09428 Q14654 | 
| #610374 | Diabetes mellitus, transient neonatal, 2 | Q09428 | 
| #610582 | Diabetes mellitus, transient neonatal, 3 | Q14654 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 | P43681 | 
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 | P17787 | 
| #133239 | Esophageal cancer | P04637 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #232300 | Glycogen storage disease ii | P10253 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #256450 | Hyperinsulinemic hypoglycemia, familial, 1; hhf1 | Q09428 | 
| #601820 | Hyperinsulinemic hypoglycemia, familial, 2; hhf2 | Q14654 | 
| #602485 | Hyperinsulinemic hypoglycemia, familial, 3; hhf3 | Q09428 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #240800 | Hypoglycemia, leucine-induced; lih | Q09428 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #211980 | Lung cancer | P04637 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #174800 | Mccune-albright syndrome; mas | P63092 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #159900 | Myoclonic dystonia | P14416 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #166350 | Osseous heteroplasia, progressive; poh | P63092 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #614674 | Periodic fever, menstrual cycle-dependent | P08908 | 
| #172700 | Pick disease of brain | P10636 | 
| #102200 | Pituitary adenoma, growth hormone-secreting | P63092 | 
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | Q01196 | 
| #103580 | Pseudohypoparathyroidism, type ia; php1a | P63092 | 
| #603233 | Pseudohypoparathyroidism, type ib; php1b | P63092 | 
| #612462 | Pseudohypoparathyroidism, type ic; php1c | P63092 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | P14679 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | P04637 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) Q01196 (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00016 | Oral cancer | P04637
                            (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P04637
                            (related) P04637 (marker) | 
| H00018 | Gastric cancer | P04637
                            (related) | 
| H00019 | Pancreatic cancer | P04637
                            (related) P04637 (marker) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) | 
| H00022 | Bladder cancer | P04637
                            (related) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) | 
| H00026 | Endometrial Cancer | P04637
                            (related) | 
| H00027 | Ovarian cancer | P04637
                            (related) | 
| H00028 | Choriocarcinoma | P04637
                            (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00031 | Breast cancer | P04637
                            (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) P14679 (marker) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00042 | Glioma | P04637
                            (related) P04637 (marker) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00046 | Cholangiocarcinoma | P04637
                            (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00055 | Laryngeal cancer | P04637
                            (related) P04637 (marker) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00069 | Glycogen storage diseases (GSD) | P10253
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00168 | Oculocutaneous albinism (OCA) | P14679
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) | P17787
                            (related) P43681 (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00244 | Pseudohypoparathyroidism | P63092
                            (related) | 
| H00441 | Progressive osseous heteroplasia (POH) | P63092
                            (related) | 
| H00501 | Fibrous dysplasia, polyostotic | P63092
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q01196
                            (related) Q01196 (marker) Q03164 (related) Q03164 (marker) | 
| H00003 | Acute myeloid leukemia (AML) | Q01196
                            (related) Q01196 (marker) Q13951 (marker) | 
| H00978 | Thrombocytopenia (THC) | Q01196
                            (related) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00512 | Permanent neonatal diabetes mellitus (PNDM) | Q09428
                            (related) Q14654 (related) | 
| H00513 | Transient neonatal diabetes mellitus (TNDM) | Q09428
                            (related) Q14654 (related) | 
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) | Q09428
                            (related) Q14654 (related) | 
| H00409 | Type II diabetes mellitus | Q14654
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) |