PCIDB

KNApSAcK Metabolite C00026151

Metabolite

KNApSAcK Entry

id C00026151
Name Tetrahydrothalifendine / (+/-)-Tetrahydrothalifendine
CAS RN 4668-22-8
Standard InChI InChI=1S/C19H19NO4/c1-22-19-14-9-20-5-4-12-7-17-18(24-10-23-17)8-13(12)15(20)6-11(14)2-3-16(19)21/h2-3,7-8,15,21H,4-6,9-10H2,1H3
Standard InChI (Main Layer) InChI=1S/C19H19NO4/c1-22-19-14-9-20-5-4-12-7-17-18(24-10-23-17)8-13(12)15(20)6-11(14)2-3-16(19)21/h2-3,7-8,15,21H,4-6,9-10H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 37

Link

ChEMBL

By standard InChI CHEMBL1330951
By standard InChI Main Layer CHEMBL1330951 CHEMBL1457510 CHEMBL2334880

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 1

Family

family name count
Ranunculaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Thalictrum fendleri Engelm. 46968 Ranunculaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

29 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1457510 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1330951 CHEMBL1738312 (1)
0 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL1330951 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1457510 CHEMBL2334880 CHEMBL2342847 (2) CHEMBL2343276 (2)
CHEMBL2343280 (2) CHEMBL2343284 (2)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1330951 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1330951 CHEMBL1794585 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1457510 CHEMBL1741325 (1)
0 / 1
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1457510 CHEMBL2334880 CHEMBL2342830 (2) CHEMBL2343279 (2)
CHEMBL2343283 (2)
2 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1330951 CHEMBL1794495 (1)
2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1457510 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1330951 CHEMBL1794486 (1)
0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme CHEMBL1330951 CHEMBL1737961 (1)
1 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1330951 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1330951 CHEMBL2114843 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1330951 CHEMBL1794401 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1457510 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1457510 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1457510 CHEMBL2334880 CHEMBL2343277 (2) CHEMBL2343281 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1457510 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1457510 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1457510 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1330951 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1330951 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1330951 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL1457510 CHEMBL2334880 CHEMBL2342846 (2) CHEMBL2343278 (2)
CHEMBL2343282 (2)
1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1330951 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1330951 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1330951 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1330951 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103780 Alcohol dependence P14416
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#159900 Myoclonic dystonia P14416
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (14)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)