PCIDB

KNApSAcK Metabolite C00025252

Metabolite

KNApSAcK Entry

id C00025252
Name Rotundine / l-Tetrahydropalmatine / (-)-Tetrahydropalmatine / (-)-Rotundine(Stephania)
CAS RN 483-14-7
Standard InChI InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 37

Link

ChEMBL

By standard InChI CHEMBL487182
By standard InChI Main Layer CHEMBL187892 CHEMBL487182 CHEMBL2334889

KEGG

By LinkDB C02890

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 24

Family

family name count
Menispermaceae 23
Papaveraceae 1

List (24)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Chasmanthera dependens Hochst 341014 Menispermaceae eudicotyledons Viridiplantae
Corydalis caseana A.Gray. 3463 Papaveraceae eudicotyledons Viridiplantae
Parabaena sagittata Miers 152350 Menispermaceae eudicotyledons Viridiplantae
Stephania bancroftii F.M.Bailey 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania brachyandra Diels 152368 Menispermaceae eudicotyledons Viridiplantae
Stephania dicentrinifera H.S.Lo.et.M.Yang 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania dielsiana Y.C.Wu 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania dolichopoda Diels 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania glabra Miers 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania hainanensis H.S.Lo & Y. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania intermedia 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania kuinanensis H.S.Lo. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania kwangsiensis H.S.Lo 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania mashanica H.S.Lo & B.N. 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania micrantha H.S.Lo 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania pierrei Diels 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania sasakii Hayata 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania sinica Diels 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania suberosa Forman 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania succinifera H.S.Lo 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania tetrandra S.Moore 425106 Menispermaceae eudicotyledons Viridiplantae
Stephania venosa Spreng 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania viridiflavens H.S.Lo & M.Yang 147243 Menispermaceae eudicotyledons Viridiplantae
Stephania yunnanensis H.S Lo 147243 Menispermaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL487182 CHEMBL2334889 CHEMBL2343280 (2) CHEMBL2343284 (2)
0 / 0
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL487182 CHEMBL2334889 CHEMBL2343279 (2) CHEMBL2343283 (2)
2 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL187892 CHEMBL839610 (1)
1 / 0
P13726 Tissue factor Membrane receptor CHEMBL187892 CHEMBL487182 CHEMBL2319887 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL487182 CHEMBL1941568 (1) CHEMBL1941569 (1)
1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL487182 CHEMBL2334889 CHEMBL2343277 (2) CHEMBL2343281 (2)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL187892 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL487182 CHEMBL2334889 CHEMBL2343278 (2) CHEMBL2343282 (2)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (2)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)