Species

KNApSAcK Entry

Organism name Stephania sinica Diels
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025123 External link 512 Runanine
/ (-)-Runanine
No. 559 No. 4

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00025604 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00025252 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025252 2 / 0
O75496 Geminin Unclassified protein C00025604 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
P13726 Tissue factor Membrane receptor C00025252 0 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025252 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025604 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025604 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025252 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (3)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)