Species

KNApSAcK Entry

Organism name Stephania glabra Miers
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025630 External link 512 Stephanine
/ l-Stephanine
/ (-)-Stephanine
/ (R)-(-)-Stephanine
CHEMBL601020
C054160
1 / 0 / 0 No. 20 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026048 External link 512 Stepharanin
/ Stepharanine
CHEMBL251229
1 / 0 / 1 No. 155 No. 4
C00025272 External link 512 Stepharine
/ (+)-Stepharine
CHEMBL463957
CHEMBL1975436
C009320
No. 688

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P13726 Tissue factor Membrane receptor C00025241 C00025252 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00025252 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00025252 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 C00026048 0 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00025252 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00025252 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025604 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
O75496 Geminin Unclassified protein C00025604 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025630 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025604 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025604 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (3)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)