Species

KNApSAcK Entry

Organism name Stephania sasakii Hayata
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025276 External link 512 Thalrugosine
/ (+)-Thalrugosine
C060802
0 / 1 No. 10 No. 4
C00025249 External link 512 Stesakine
/ (-)-Stesakine
No. 20 No. 4
C00025699 External link 512 (R)-Roemeroline
CHEMBL499835
No. 20 No. 4
C00025750 External link 512 4-Hydroxycrebanine
No. 20 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025935 External link 512 Lysicamine
/ Oxonuciferine
CHEMBL510090
C069090
No. 74
C00025319 External link 512 Oxoxylopin
/ Oxoxylopine
/ Lanuginosine
CHEMBL389400
1 / 4 / 2 No. 74
C00025787 External link 512 Cepharadione A
CHEMBL235921
No. 125
C00026125 External link 512 Dehydrocrebanine
No. 416
C00025847 External link 512 Dehydrostesakine
No. 416
C00025845 External link 512 Dehydroroemerine
/ Dehydroremerine
/ 6a,7-Didehydroaporheine
CHEMBL1171263
C030170
No. 416
C00025844 External link 512 Dehydrophanostenine
No. 416
C00026051 External link 512 Steporphine
No. 553
C00025104 External link 512 Cepharamine
No. 559 No. 4
C00025749 External link 512 4,5-Dioxodehydrocrebanine
No. 800
C00025990 External link 512 O-Methylpunjabine
CHEMBL2009722
No. 815
C00026030 External link 512 Secocepharanthine
No. 815
C00025987 External link 512 O-Methyldeoxopunjabine
No. 815
C00025854 External link 512 Dihydrosecocepharanthine
No. 815

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025252 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025252 2 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P00734 Prothrombin S1A C00025319 4 / 2
P13726 Tissue factor Membrane receptor C00025252 0 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025252 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025252 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (4)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D013927 Thrombosis C00025276