PCIDB

Stephania kwangsiensis H.S.Lo

Species

KNApSAcK Entry

Organism name Stephania kwangsiensis H.S.Lo
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025846 External link 512 Dehydrostephanine
/ 1,2-Methylenedioxy-8-methoxydehydroaporphine
C030171
No. 416
C00025845 External link 512 Dehydroroemerine
/ Dehydroremerine
/ 6a,7-Didehydroaporheine
CHEMBL1171263
C030170
No. 416

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025252 C00026150 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025252 C00026150 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025604 C00025625 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025604 C00025625 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 C00026150 0 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 C00025625 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025252 C00026150 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025252 C00026150 2 / 0
P03372 Estrogen receptor NR3A1 C00025252 C00026150 1 / 1
P13726 Tissue factor Membrane receptor C00025252 C00026150 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 C00026150 1 / 0
O75496 Geminin Unclassified protein C00025604 C00025625 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025604 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0
O00255 Menin Unclassified protein C00025625 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025625 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#114500 Colorectal cancer; crc P84022
#615363 Estrogen resistance; estrr P03372
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#614674 Periodic fever, menstrual cycle-dependent P08908
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (15)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)