Species

KNApSAcK Entry

Organism name Stephania suberosa Forman
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (22)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025273 External link 512 (+)-Stephasubine
No. 10 No. 4
C00025346 External link 512 Stephasubimine
No. 10 No. 4
C00025270 External link 512 (+)-Norstephasubine
No. 10 No. 4
C00025639 External link 512 2-Norcepharanthine
/ (+)-2-Norcepharanthine
No. 10 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025247 External link 512 Stephabinamine
/ (-)-Stephabinamine
No. 37 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00025253 External link 512 9-O-Desmethyl-L-THP
/ (-)-Tetrahydropalmatrubine
CHEMBL522746
CHEMBL2314745
CHEMBL2334884
5 / 3 / 0 No. 37 No. 4
C00025254 External link 512 (-)-Tetrahydrostephabine
CHEMBL516695
No. 37 No. 4
C00025238 External link 512 Discretine
/ (-)-Discretine
CHEMBL513084
No. 37 No. 4
C00025234 External link 512 Corytenchin
/ Corytenchine
/ (-)-Corytenchine
No. 37 No. 4
C00025233 External link 512 Coramine
/ Coreximin
/ Coreximine
/ (S)-Coreximine
/ (-)-Coreximine
/ Coramine(alkaloid)
CHEMBL1164087
No. 37 No. 4
C00025600 External link 512 Capaurimine
/ (-)-Capaurimine
No. 37 No. 4
C00026094 External link 512 Stepholidine
/ (-)-Stepholidine
CHEMBL487387
CHEMBL2334890
C010513
7 / 4 / 0 0 / 1 No. 37 No. 4
C00025343 External link 512 Stephabine
No. 155 No. 4
C00025342 External link 512 Pseudopalmatine
/ 5,6-Dihydro-8-demethylcoralyne
CHEMBL376300
No. 155 No. 4
C00025256 External link 512 (-)-trans-Xylopinine N-oxide
No. 234
C00025232 External link 512 (-)-cis-Xylopinine N-oxide
No. 234
C00025913 External link 512 Isostephodeline
/ (+)-Isostephodeline
/ (+)-14-Epierromangine
No. 346 No. 4
C00025345 External link 512 Stephaphylline
No. 559 No. 4
C00025344 External link 512 Stephanubine
No. 559 No. 4
C00025298 External link 512 Delavaine
/ (-)-Delavaine
No. 2981

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00025252 C00025253 C00026094 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00025252 C00025253 C00026094 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00025252 C00025253 C00026094 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00025252 C00025253 C00026094 0 / 0
P13726 Tissue factor Membrane receptor C00025241 C00025252 C00025253 C00026094 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P21917 D(4) dopamine receptor Dopamine receptor C00026094 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
P21918 D(1B) dopamine receptor Dopamine receptor C00026094 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#606798 Blepharospasm, benign essential P21918
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (2)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D004409 Dyskinesia, Drug-Induced C00026094