Species

KNApSAcK Entry

Organism name Stephania micrantha H.S.Lo
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025602 External link 512 l-Curine
/ (-)-Curine
/ l-Bebeerine
/ Aristolochine
/ (-)-Bebeerine
/ Aristolochine(C36 alkaloid)
CHEMBL1169627
13 / 6 / 5 No. 10 No. 4
C00025655 External link 512 Corytuberine
/ (+)-Corytuberine
CHEMBL227965
C013896
1 / 0 / 0 No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026094 External link 512 Stepholidine
/ (-)-Stepholidine
CHEMBL487387
CHEMBL2334890
C010513
7 / 4 / 0 0 / 1 No. 37 No. 4
C00026117 External link 512 Corypalmine
/ (-)-Corypalmine
CHEMBL2334885
CHEMBL2334886
4 / 3 / 0 No. 37 No. 4
C00025845 External link 512 Dehydroroemerine
/ Dehydroremerine
/ 6a,7-Didehydroaporheine
CHEMBL1171263
C030170
No. 416
C00025843 External link 512 Dehydroisolaureline
No. 416
C00025846 External link 512 Dehydrostephanine
/ 1,2-Methylenedioxy-8-methoxydehydroaporphine
C030171
No. 416

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00025252 C00026094 C00026117 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00025252 C00026094 C00026117 2 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00025252 C00026094 C00026117 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00025252 C00026094 C00026117 0 / 0
P13726 Tissue factor Membrane receptor C00025241 C00025252 C00026094 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025602 C00025604 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00025655 C00025827 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025602 C00025604 1 / 1
O75496 Geminin Unclassified protein C00025602 C00025604 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025602 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00026094 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00025602 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
P42858 Huntingtin Unclassified protein C00025602 1 / 1
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00025602 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025602 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025604 0 / 0
P21918 D(1B) dopamine receptor Dopamine receptor C00026094 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025602 4 / 3
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 0 / 0
O43603 Galanin receptor type 2 Galanin receptor C00025602 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025602 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025602 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025602 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#606798 Blepharospasm, benign essential P21918
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#159900 Myoclonic dystonia P14416
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (7)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D004409 Dyskinesia, Drug-Induced C00026094