Stephania tetrandra S.Moore

• Index
• Plant Species
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Stephania tetrandra S.Moore
Genus	Stephania
Family	Menispermaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Stephania tetrandra
Linked NCBI taxonomy ID	425106
Linked level	species

Family

Family in NCBI taxonomy	Menispermaceae
ID	3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00025873	Fenfangjine A / Tetrandrine 2beta-oxide / Tetrandrine 2beta-N-oxide					No. 10	No. 4
C00025994	Oxofangchirine / (+)-Oxofangchirine		C049410			No. 10	No. 4
C00025306	Fangchinoline / dl-Fangchinoline / 7-O-Demethyltetrandrine	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3		No. 10	No. 4
C00025310	Homoaromoline / (+)-Homoaromoline / (+)-Thalrugosamine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978				No. 10	No. 4
C00025602	l-Curine / (-)-Curine / l-Bebeerine / Aristolochine / (-)-Bebeerine / Aristolochine(C36 alkaloid)	CHEMBL1169627		13 / 6 / 5		No. 10	No. 4
C00025875	Fenfangjine D / Berbacolorflammine hydroxide / 1,2,3,4-Tetradehydrofangchinolinium hydroxide					No. 10	No. 4
C00025662	(+)-Limacine / (+)-Fangchinoline	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3		No. 10	No. 4
C00025738	2'-Norfangchinoline / 2'-Demethyl-(+)-limacine / 2'-Demethylfangchinoline	CHEMBL508608				No. 10	No. 4
C00025874	Fenfangjine B					No. 10	No. 4
C00025604	Cycleanine / (-)-Cycleanine	CHEMBL1711244 CHEMBL1983719	C037098	7 / 1 / 1		No. 10	No. 4
C00025953	Nantenine / Domestine / (+)-Domestine / (+)-Nantenine / O-Methyldomesticine	CHEMBL179440 CHEMBL467094		38 / 10 / 2		No. 20	No. 4
C00025252	Rotundine / l-Tetrahydropalmatine / (-)-Tetrahydropalmatine / (-)-Rotundine(Stephania)	CHEMBL187892 CHEMBL487182 CHEMBL2334889		8 / 5 / 2		No. 37	No. 4
C00025995	Oxonantenine	CHEMBL1270949				No. 74
C00025782	Cassameridin / Cassameridine					No. 74
C00025295	beta-Cyclanoline / (-)-b-Cyclanoline	CHEMBL2008127				No. 234
C00026120	Cyclanoline / (-)-Cissamine / alpha-Cyclanoline	CHEMBL2008127	C060801			No. 234
C00026050	Stephenanthrine / De-N-methyl-1-isoremerine	CHEMBL492418	C049411	5 / 6 / 6		No. 639
C00026043	Stephadione					No. 800
C00025828	Corydione / 4,5-Dioxodehydronantenine					No. 800
C00025982	Oblongine / (+)-Oblongine	CHEMBL457373	C081049			No. 896

Human Protein / Gene in interactions

67 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00025306 C00025602 C00025604 C00025662	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00025306 C00025602 C00025604 C00025662	0 / 0
O75496	Geminin	Unclassified protein	C00025306 C00025602 C00025604 C00025662	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00025306 C00025604 C00025662	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00025306 C00025604 C00025662	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00025306 C00025662 C00025953	0 / 1
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00025252 C00025953	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00025306 C00025662	1 / 1
P35372	Mu-type opioid receptor	Opioid receptor	C00025602 C00025953	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00025602 C00026050	4 / 3
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00025306 C00025662	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00025602 C00025953	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00025252 C00025953	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00025306 C00025662	2 / 0
P39748	Flap endonuclease 1	Enzyme	C00025306 C00025662	0 / 0
P47898	5-hydroxytryptamine receptor 5A	Serotonin receptor	C00025602 C00025953	0 / 0
P08183	Multidrug resistance protein 1	drug	C00025306 C00025662	1 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00025306 C00025662	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00025252 C00025953	2 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00025252	0 / 1
P41145	Kappa-type opioid receptor	Opioid receptor	C00025953	0 / 0
P28566	5-hydroxytryptamine receptor 1E	Serotonin receptor	C00025953	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00026050	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00025953	0 / 0
P42858	Huntingtin	Unclassified protein	C00025602	1 / 1
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P21918	D(1B) dopamine receptor	Dopamine receptor	C00025953	1 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00025953	0 / 0
P35348	Alpha-1A adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00025953	1 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P46098	5-hydroxytryptamine receptor 3A	NS	C00025953	0 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00025953	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00025252	1 / 0
Q9H3N8	Histamine H4 receptor	Histamine receptor	C00025953	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00025953	1 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00025953	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00025953	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00025953	2 / 0
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00025953	1 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00025953	0 / 0
P13726	Tissue factor	Membrane receptor	C00025252	0 / 0
P03372	Estrogen receptor	NR3A1	C00025252	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00025953	1 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00025953	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00025953	0 / 0
P28222	5-hydroxytryptamine receptor 1B	Serotonin receptor	C00025953	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00025953	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00026050	2 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00025604	0 / 0
P25021	Histamine H2 receptor	Histamine receptor	C00025953	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00026050	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00025604	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00025252	1 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00025953	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P28221	5-hydroxytryptamine receptor 1D	Serotonin receptor	C00025953	0 / 0
P35368	Alpha-1B adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00025953	0 / 0
O43603	Galanin receptor type 2	Galanin receptor	C00025602	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00025602	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00026050	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00025602	0 / 0
Q9Y5N1	Histamine H3 receptor	Histamine receptor	C00025953	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00025602	0 / 0
P43351	DNA repair protein RAD52 homolog	Unclassified protein	C00025602	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions