Species

KNApSAcK Entry

Organism name Stephania venosa Spreng
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00025294 External link 512 Ayuthianine
/ (-)-Ayuthianine
No. 20 No. 4
C00025244 External link 512 (-)-Nuciferoline
/ (R)-(-)-Nuciferoline
No. 20 No. 4
C00025242 External link 512
/ (-)-Mecambroline
/ (R)-(-)-Mecambroline
No. 20 No. 4
C00025241 External link 512 Kikemanin
/ Kikemanine
/ Corydalmine
/ Schefferine
/ (-)-Kikemanine
/ (-)-Corydalmine
CHEMBL448891
CHEMBL1209608
CHEMBL2334894
C058198
5 / 3 / 0 No. 37 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025339 External link 512 Oxocrebanine
/ 8,9-Dimethoxyliriodenine
No. 74
C00025349 External link 512 Thailandine
No. 74
C00025341 External link 512 Oxostephanosine
No. 74
C00025354 External link 512 Uthongine
No. 74
C00025340 External link 512 Oxostephanine
CHEMBL521933
No. 74
C00025251 External link 512 (-)-Sukhodianine beta-N-oxide
No. 286 No. 4
C00026125 External link 512 Dehydrocrebanine
No. 416
C00025259 External link 512 N-Oxyushinsunine
/ Ushinsunine N-oxide
/ (-)-Ushinsunine beta-N-oxide
CHEMBL517632
CHEMBL517212
No. 553
C00025258 External link 512 Micheline A
/ (-)-Ushinsunine
CHEMBL221034
CHEMBL1617041
CHEMBL2009013
1 / 0 / 0 No. 553
C00026042 External link 512 Stephadiolamine beta-N-oxide
/ (-)-Stephadiolamine beta-N-oxide
/ (-)-4alpha-Hydroxyushinsunine beta-N-oxide
No. 553
C00025272 External link 512 Stepharine
/ (+)-Stepharine
CHEMBL463957
CHEMBL1975436
C009320
No. 688
C00025246 External link 512 (-)-O-Methylstepharinosine
No. 1032
C00025357 External link 512 (-)-Stepharinosine
No. 1032

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025241 C00025252 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025241 C00025252 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025241 C00025252 2 / 0
P13726 Tissue factor Membrane receptor C00025241 C00025252 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025241 C00025252 1 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
P22303 Acetylcholinesterase Hydrolase C00025231 1 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00025258 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
P03372 Estrogen receptor NR3A1 C00025252 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#615363 Estrogen resistance; estrr P03372
#159900 Myoclonic dystonia P14416
#614674 Periodic fever, menstrual cycle-dependent P08908
#112100 Yt blood group antigen P22303

KEGG DISEASE (2)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)