Species

KNApSAcK Entry

Organism name Stephania pierrei Diels
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001843 External link 512 Daphnandrine
/ (+)-Daphnandrine
/ O12'-Methyldaphnoline
CHEMBL502441
CHEMBL510612
No. 10 No. 4
C00025265 External link 512 Homoaromoline
/ Homothalicrine
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025275 External link 512 Homoaromoline
/ Homothalicrine
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025274 External link 512 Stephibaberine
/ (+)-Stephibaberine
CHEMBL463946
No. 10 No. 4
C00025261 External link 512 2-Norisotetrandrine
/ (+)-2-Norisotetrandrine
No. 10 No. 4
C00025260 External link 512 2-Norberbamine
/ (+)-2-Norberbamine
/ 2-Demethylberbamine
No. 10 No. 4
C00025266 External link 512 Isosinomenin A
/ Isotetrandrine
/ Isosinomenine A
/ O-Methylberbamine
/ (+)-Isotetrandrine
/ O,O-Dimethylobamegine
/ O,O'-Dimethylobamegine
/ O,O-Dimethylstepholine
/ O,O'-Dimethylstepholine
No. 10 No. 4
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00025607 External link 512 NSC 251699
/ L-Dicentrine
/ (-)-Dicentrine
/ (R)-(-)-Dicentrine
CHEMBL464748
CHEMBL478754
15 / 20 / 16 No. 20 No. 4
C00025255 External link 512 (-)-Thaicanine
CHEMBL465823
No. 37 No. 4
C00025254 External link 512 (-)-Tetrahydrostephabine
CHEMBL516695
No. 37 No. 4
C00025252 External link 512 Rotundine
/ l-Tetrahydropalmatine
/ (-)-Tetrahydropalmatine
/ (-)-Rotundine(Stephania)
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00025262 External link 512 Berbamunine
/ (+)-Berbamunine
CHEMBL1187468
No. 89 No. 4
C00025268 External link 512 (+)-N-Methylcoclaurine
/ (+)-(S)-N-Methylcoclaurine
CHEMBL453292
CHEMBL513109
No. 253 No. 4
C00025298 External link 512 Delavaine
/ (-)-Delavaine
No. 2981

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00025252 0 / 0
P06746 DNA polymerase beta Enzyme C00025607 0 / 0
P02545 Prelamin-A/C Unclassified protein C00025607 11 / 10
P24941 Cyclin-dependent kinase 2 Cdc2 C00025607 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025607 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00025252 2 / 0
P39748 Flap endonuclease 1 Enzyme C00025607 0 / 0
O75496 Geminin Unclassified protein C00025607 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00025252 1 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025607 1 / 2
P13726 Tissue factor Membrane receptor C00025252 0 / 0
P03372 Estrogen receptor NR3A1 C00025252 1 / 1
P22303 Acetylcholinesterase Hydrolase C00025231 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00025252 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025252 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025607 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025607 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025607 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00025607 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00025252 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025607 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025607 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00025607 2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025607 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#112100 Yt blood group antigen P22303

KEGG DISEASE (18)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)